58 results about "Helleborus thibetanus" patented technology

The invention discloses a Helleborus thibetanus extract, a separation method of effective components in the Helleborus thibetanus extract and compounds obtained by the separation method. The Helleborus thibetanus extract is obtained by the following steps: respectively extracting a Helleborus thibetanus medicinal material by the use of 95% ethanol and 50% ethanol which account for 6-8 times the weight of the Helleborus thibetanus medicinal material for 2-4 times, merging extracts, condensing and drying, adding water for dispersion, successively carrying out extraction by the use of petroleum ether and ethyl acetate, condensing an ethyl acetate extract, and drying. It is found through an experimental research that the ethyl acetate extraction part in the ethanol extract of the Helleborus thibetanus extract has good pain-suppressing and anti-inflammatory effects, and the ethyl acetate extraction part can be used in the preparation of an anti-inflammatory and pain-suppressing medicine; and 17 compounds are obtained by separation of the ethyl acetate extraction part, wherein two compounds are new compounds and 12 compounds are firstly obtained by separation of Helleborus thibetanus. The invention lays a foundation for establishing content determination items of the Helleborus thibetanus medicinal material and a medicinal preparation containing Helleborus thibetanus, is beneficial to raising quality standard and quality controllability of the Helleborus thibetanus medicinal material and lays a foundation for further development and utilization of Helleborus thibetanus.

The present invention relates to helleborus thibetanus medicinal liquor for effectively curing the diseases of rheumalgia, traumatic injuries, rheumatic arthritis, rheumatic arthralgia and myalgia and arthralgia due to wind-cold-dampness, etc. Said medicinal liquor is made up by using Chinese medicinal materials of helleborus thibetanus, shibazheng, randia spinosa, pangxueteng, rabdosia rubescens and white liquor through a certain preparation process.

The invention discloses a beta cardiac glycoside and a preparation method and application thereof. The structure of the beta cardiac glycoside is as follows: the compound is extracted from Helleborus thibetanus (Ranunculaceae): dry powder at the rhizome part of the Helleborus thibetanus is soaked with 95% ethanol, and then is concentrated under reduced pressure to obtain a concentrated solution; the concentrated solution is respectively extracted by using ethyl acetate and n-butyl alcohol which are equal in volume; column chromatography separation is peformed on an n-butanol extraction phase by adopting a D101 macroporous resin column, a normal-phase silica gel column, a reverse-phase ODS (Octadecylsilyl), a gel column and the like, and finally purifying is performed by adopting semi-preparative high performance liquid chromatography. The beta cardiac glycoside has a good inhibition effect on angiogenesis of human umbilical vein endothelial cells (HUVEC) so that the beta cardiac glycoside can be prepared into a novel anti-angiogenesis medicine. The invention provides a material basis for novel anti-vascular drugs, and is beneficial to further development of medicinal value and clinical application of helleborus thibetanus.

The invention discloses a pharmaceutical preparation for treating asthma and a preparing method, and belongs to the field of traditional Chinese medicine. The pharmaceutical preparation comprises stachys sieboldi miq, ruddle, fourleaf peperomia herbs, mountain ash, herbs of ceylon leucas, asarum maximum, seeds of zanthoxylom bungeanum maxim, lemon, hibiscus syriacus, india mustard seeds, herbs of common evolvulus, coffee senna seeds, herbs of cuneate lespedeza, helleborus thibetanus, ginkgo seeds and marsdenia longipes. The selected medicinal materials of the pharmaceutical preparation are suitable in compatibility, the traditional Chinese medicine theory and the modern medicine theory are met, and the pharmaceutical preparation has the effects of clearing heat, removing toxicity, relieving coughing and asthma, clearing the lung and the liver, astringing the lung and relieving asthma, and is convenient to use, good in absorption effect and free of poor, toxic and side effects; according to clinical verification, the pharmaceutical preparation has the quite good relieving effect and the quite good treating effect on treating asthma, and is suitable for clinic treating and nursing applying and popularizing of asthma.

The invention discloses a traditional Chinese medicinal preparation for treating Henoch-Schonlein purpura nephritis. The disease belongs to hematuria, edema, purple plague and other fields in traditional Chinese medicine. The disease is caused by pathogenic heat accumulation in body, affection by pathogenic wind or improper diet, or contact of foreign matter, resulting in fighting of wind heat and moist heat or intense toxic heat, burn of blood vessels and damage of kidney. Traditional Chinese medicinal materials with effects of clearing away heat and toxic materials, removing heat from blood to stop bleeding, discharging heat, dispelling blood stasis and nourishing liver and kidney, including Blumea lacera, Hedyotis hispida, Cephalanoplos setosum, Arnebia saxatilis, Helleborus thibetanus, Wikstroemia indica, Herba Echiptae, Osmanthus heterophyllus and Herba Lespedezae Cuneatae, are decocted in water to obtain decoction. Through clinical trials, the total effective rate is 96.7%, no adverse effect appears during medication, and no recurrence appears in 19 follow-up patients in 3 years.

The invention discloses an external application lotion for treating gynecological cervical erosion and gynecological inflammations, and a preparation method thereof. The external application lotion is prepared from the following raw materials, wherein the raw materials comprise, by weight, 40-60 parts of aconitum kusnezoffii, 20-30 parts of helleborus thibetanus franch, 20-30 parts of periploca forrestii schltr, 30-50 parts of poiret barberry root, 20-40 parts of spinyleaf pricklyash root, 30-50 parts of mahonia bealei, 20-30 parts of borneol, 0-10 parts of eucommia, 0-10 parts of honeysuckle, 0-10 parts of akabia stem and 0-10 parts of cinnamomum camphora. A plurality of natural plant drugs with effects of anti-inflammatory, detoxication, kidney-yin tonifying, congestion dissipating, impurity discharging, body resistance supporting and basis consolidating, are screened through the formula of the external application lotion. The external application lotion belongs to the filed of external application drugs, therefore the external application lotion provided by the present invention does not have any side effect. According to theoretical formulations inherited from traditional Miaomedicine, the external application lotion provided by the present invention can provide a strong therapeutic effect for the gynecological cervical erosion and the gynecological inflammations. In addition, the external application lotion does not contain antibiotics and has no stimulation to human body.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine capsule for treating lymphoma and a preparation method thereof. The traditional Chinese medicine capsules are prepared by the following traditional Chinese medicine raw materials according to the parts by weight: 15-20 parts of Prunella vulgaris, 10-15 parts of seaweed, 10-15 parts of xanthophyll seed, 20-25 parts of Salvia miltiorrhiza, 8-10 parts of blood dried flower, Chuanxiong 8-10 parts, 15-20 parts of curcuma, 8-10 parts of ground beetle, 8-10 parts of centipede, 10-15 parts of red peony, 15-20 parts of turtle shell, 25-30 parts of Hedyotis diffusa, Ebony vine 35-40 parts, iron chopsticks 35-40 parts, astragalus 8-10 parts, heterophylla 10-15 parts, Atractylodes macrocephala 10-15 parts, jujube 6-8 parts, angelica 8-10 parts, raw land 8-10 parts, 8-10 parts of Ophiopogon japonicus, 8-10 parts of wolfberry, 15-20 parts of donkey-hide gelatin. The traditional Chinese medicine of the present invention has the effects of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, has remarkable curative effect on lymphoma, can improve the immune function of the human body, inhibit the generation and spread of cancer cells, and play the role of antibacterial and anti-inflammatory, toxin and pus drainage, and stagnation and swelling reduction. The medicinal material is easy to obtain, the cost is low, the cure rate is high, there is no recurrence after the cure, it is safe and reliable, and it is worthy of widespread clinical application.

The invention relates to a traditional Chinese medicine for treating alveolar hypoventilation syndrome, which is prepared from the following medical materials in weight ratio: 12 parts of helleborus thibetanus, 8 parts of caesalpinia cucullata, 10 parts of antelope horns, 12 parts of sea horses, 14 parts of common andrographis herb, 10 parts of crocus sativus, 8 parts of radix scrophulariae, 9 parts of salvia chinensis, 12 parts of blister beetles, 14 parts of cortex lycii radicis, 12 parts of butterflybush flower, 10 parts of rehmannia glutinosa libosch, 14 parts of moutan barks and 12 parts of rhizome anemarrhenae. Proved by clinical experiments, the traditional Chinese medicine can be used for safely and effectively treating alveolar hypoventilation syndrome.

The invention discloses a traditional Chinese medicine preparation for nursing diabetes and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation disclosed by the invention comprises the following crude drugs: semen pharbitidis, corn stigma, astragalus membranaceus, cyclocarya paliurus, pyrrosia lingua, coffee senna, herba aristolochiae, pine needle, rhizoma smilacis glabrae, gardenia, helleborus thibetanus, flatstem milkvetch seed, water hyacinth, soletellina diphos, folium ilicis purpurea and running mallow root. The traditional Chinese medicine preparation disclosed by the invention is appropriate in compatibility of selected medicinal materials, accords with the theories of the traditional Chinese medicine and pharmacy and the modern medicine and pharmacology, has the effects of inducing diuresis to reduce edema, tonifying the liver and the kidneys, calming the liver and benefitting bile, can be used for repairing pancreas damaged tissue, has a significant treatment effect on various symptoms caused by the diabetes, is safe and reliable, free of toxic and side effects, low in price, strange in effect and practical, and worthy of extensive popularization and application in clinic, and is used for treating both symptoms and root causes.

The invention provides a tissue culture propagation method for helleborus thibetanus. The tissue culture propagation method comprises the following steps of (1), obtaining and treating an explant; (2), carrying out adventitious bud induction culture; (3), carrying out adventitious bud subculture multiplication culture; (4), rooting culture; and (5), hardening seedlings and transplanting to obtain helleborus thibetanus seedlings. According to the method, hormone and a culture environment are comprehensively adjusted, so that the proliferation multiple of the adventitious buds of the helleborus thibetanus reaches 3.5 or above, the rooting rate reaches 90% or above, and the problems that the helleborus thibetanus is low in propagation coefficient, difficult to root and long in production period are solved; and besides, by keeping the excellent characters of the excellent strains, seedlings with stable excellent characters can be produced, standardization and factory operation are easy, and the excellent seedlings with the unified standard are provided for the market.

The invention provides a cold-curing preparation and a detection method for an intermediate product. The cold-curing preparation is prepared from Geum japonicum Thunb, Helleborus thibetanus, Folium Hibisci Mutabilis, purple perilla, fewflower lysionotus herb, herba kalimeridis, Schizonepeta, and auxiliary materials. Compared with the prior art, on the basis of current cold-curing preparation quality control, a method for measuring the content of gallic acid and lysionotin of an intermediate product and a preparation is added to the detection method. The detection method is accurate; the sensitivity is high; the repeatability is good; the detection result is stable; and the quality of the cold-curing preparation can be effectively controlled.

The present invention discloses a helleborus thibetanus Qufeng Tongluo Zhitong medicine for effectively curing the diseases of rheumatic arthralgia, rheumatic arthritis, rheumatoid arthritis, traumatic injury and solf tissue contusion, etc. with obvious therapeutic effect. It is made up by using 14 Chinese medicinal materials of helleborus thibetanus, aliteng, asarum sieboldii, peperomia terraphylla, lamiophlomis rotata and others and adding ethyl alcohol through a certain preparation process.

The invention discloses ointment for orthopedics department. The ointment is prepared from the following raw materials: 9 to 12 parts of pseudodrynaria coronans, 7 to 10 parts of semen impatientis, 4 to 6 parts of spica prunellae, 12 to 14 parts of radix notoginseng, 9 to 13 parts of radix alangii, 5 to 6 parts of radix angelicae lateralis preparata, 8 to 9 parts of sangusis draconis, 10 to 12 parts of myrrh, 6 to 8 parts of helleborus thibetanus, 4 to 5 parts of camphor, 5 to 7 parts of saffron, 9 to 11 parts of radix dipsaci, 6 to 9 parts of frankincense and 5 to 8 parts of radix et rhizoma rhei. The ointment disclosed by the invention can be used for rapidly improving microcirculation so that pain and numbness are rapidly eliminated and a fibrous ring of an intervertebral disk is rapidly repaired, and furthermore, the effect of obtaining immediate result is realized; the ointment has rapid and good curative effect and no side effect; the ointment for the orthopedics department, which is reasonably blended, has the advantages that the raw materials are convenient to take and a preparation process is simple, convenient and easy; the treatment cost of patients is low and the curative effect is rapid.

The present invention discloses a Qushi Zhentong medicine liquor for effectively curing the diseases of rheumatoid arthritis, rheumatic numbness, chronic arthralgia, rheumatic arthralgia and myalgia, soft tissue injury and traumatic injury, etc. with obvious therapeutic effect. It is made up by using 5 Chinese medicinal materials of coral ardisia root, helleborus thibetanus, rabdosia rubescens, impatiens balsamina root, glechoma hederacea and white liquor through a certain preparation process. Its therapeutic effect is reliable, and its cure rate is above 90%.

The invention provides an extraction method of a plant composition containing herba epimedii. The plant composition is prepared from 100 parts of herba epimedii, 40 parts of galium verum, 60 parts of helleborus thibetanus and 50 parts of rubus pluribracteatus roots by adopting the microwave extraction method, therefore, the content is greatly increased, and the using amount is decreased. The invention further provides an application of the plant composition containing the herba epimedii in preparation of medicine for inhibiting proliferation of melanic rattus lung fibroblast NRL2.

The invention relates to the field of traditional Chinese medicine formula, and specifically relates to a traditional Chinese medicine composition for treating urinary tract infection. The traditional Chinese medicine composition is characterized by being composed of the following raw materials in percentage by weight: 3 to 12% of rabdosia longituba, 3 to 15% of polygonum aviculare, 6 to 10% of helleborus thibetanus, 3 to 10% of raspberry, 3 to 10% of radix berberidis, 3 to 10% of iris tectorum, 3 to 10% of folium isatidis, 5 to 10% of felwort, 5 to 20% of bighead atractylodes rhizome, 5 to 15% of hydrocharis dubia, 10 to 15% of radix aconiti lateralis preparata, 10 to 15% of pyrrosia lingua, 10 to 30% of aeginetia indica, 6 to 10% of semen lepidii, 10 to 30% of day lily, 6 to 10% of fiveleaf akebia fruit, and 2 to 10% of dayflower. The raw materials mentioned above are soaked in water, and then decocted. The decoction is filtered to remove dregs so as to obtain filtrate. The composition has the functions of clearing heat, removing toxin, excreting dampness, promoting urination, eliminating inflammation, relieving pain, boosting qi, engendering liquid, reconciling superficies and interior, dispelling wind, treating fever, and activating blood, improves the in-vivo and vi-vitro environment, and treats or relieves various symptoms of urinary tract infection.

The invention discloses a traditional Chinese medicine composition and preparation for treating rheumatoid arthritis and a preparing method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 80-100 parts of helleborus thibetanus, 20-30 parts of schisandra chinensis, 20-30 parts of ganoderma lucidum, 15-30 parts ofradix aucklandiae, 25-50 parts of vervain, 20-30 parts of radix paeoniae rubra, 30-40 parts of nduoh nyaatv buerng, 50-80 parts of a traditional Chinese medicine named 'Sanheliu' according to the Chinese pronunciation, 20-40 parts of polygonum multiflorum, and 30-60 parts of camphor root. The composition has good therapeutic effect on rheumatoid arthritis, and has the curative effect superior to that of tripterygium glycoside.