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Application of total saponins of helleborus thibetanus franch in preparing drugs for preventing and treating liver injuries

A technology of iron chopsticks and total saponins, applied in the field of hepatobiliary treatment

Inactive Publication Date: 2015-10-28
宫琳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the protective effect of total saponins in iron chopsticks on liver injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Effect test

[0016] The total saponins of iron chopsticks were prepared according to Example 2 of ZL201410550317, and the test results were determined.

[0017] (1) Main reagents and instruments:

[0018] Carbon tetrachloride (analytical pure) was purchased from Yantai Sanhe Chemical Reagent Company; olive oil was purchased from Shanghai Weihui Chemical Reagent Factory; bifendate was purchased from Zhejiang Wanbang Pharmaceutical Co., Ltd., batch number: 090205; Coomassie brilliant blue G250 was purchased From the subpackaging factory of Shanghai Chemical Reagent Company, batch number: 20050115; bovine albumin was purchased from Beijing Aoboxing Biotechnology Co., Ltd., batch number: 20100526; other reagents were of analytical grade.

[0019] Aspartate aminotransferase (GOT) kit (20110613), alanine aminotransferase (GPT) kit (20110808), malondialdehyde (MDA) kit (20110803), superoxide dismutase (SOD) assay kit (20110802) Purchased from Zhongsheng Beikong Biotechnolog...

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PUM

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Abstract

The invention relates to new application of total saponins of helleborus thibetanus franch, in particular to the new application of the total saponins of the helleborus thibetanus franch in protecting the liver function. The total saponins of the helleborus thibetanus franch is studied to find that the total saponins of the helleborus thibetanus franch has the protection function on mouse acute liver injury models prepared from carbon tetrachloride, and then is used for preventing and treating the liver injuries caused by many reasons.

Description

technical field [0001] The invention belongs to the field of hepatobiliary treatment, and relates to the application of total saponins in the preparation of a medicine for protecting acute liver injury. Background technique [0002] Liver injury is a complex process caused by multiple etiologies and involving multiple factors. Liver disease caused by liver injury has become a common and frequently-occurring disease. What is more serious is the liver failure and hepatic encephalopathy caused by it. The morbidity and mortality are high, which greatly threatens human health. Many factors can cause liver injury, and the in vivo model, especially the chemical liver injury model, is similar to human chronic liver disease in some aspects of morphology and pathophysiology. intraperitoneal injection of CCl 4 Vegetable oil solution is currently a commonly used hepatitis model. CCl 4 The mechanism of liver injury is CCl 4 Generation of free radical CCl by activation of hepatic mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16
Inventor 宫琳施露
Owner 宫琳
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