98 results about "Glucosamine hcl" patented technology

A topical skin rejuvenation preparation to relieve wrinkles, increase the skin's natural production of hyaluronic acid, reverse the lack of suppleness, hydrate from within, erase spider veins, reduce varicose veins, lighten aging dark blotches (“liver spots” / Lentigos, Senile Lentigines), decrease acne, and reduce under eye puffiness includes Glucosamine (2-amino-2-deoxy-alpha-D-glucose), a hexosamine (6 carbon amino sugar), including its derivative and precursor compounds: Glucosamine Sulfate, Glucosamine Hydrochloride, Glucose-6-Phosphate, Acetyl Glucosamine, Fructose-6-phosphate, Glucosamine-6-Phosphate, to increase production of Hyaluronic acid and collagen from Glucosamine Sulfate, its precursors and derivatives and to increase skin muscle tone by Dimethylaminoethanol (DMAE) while over coming deficiency it creates in each cell's production of PhosphatidylCholine, whose deficiency damages cell membranes, as well as mitochondrial and lysosome membranes.

An animal toy containing food having a first portion with food delivery means integrated therein adapted to securely house solid food treats, including a nutritional pet supplement, to be removed by the animal during play or through chewing action, and a second side with a plurality of gum stimulation teeth integrated within and projecting therefrom that act to massage the gums of the animal. Food delivery means may be provided as a plurality of cavities integrated within the first portion (and optionally, the second portion), preferably having a grooved or threaded interior for securely holding food pieces securely therein. Alternatively, the food delivery means is provided as a food portion composing the first portion. A pet supplement may be utilized, including joint preserving and joint rebuilding compositions comprising chicken collagen type II, glucosamine hydrochloride and chondroitin sulfate, a vitamin composition comprising vitamins C, D and K, a mineral composition comprising calcium, magnesium, zinc, copper, manganese and boron, a herbal anti-oxidant cofactor blend comprising citrus bioflavonoids, red grapes anthocyanins, turmeric rhizome, boswellia resin and fennel seed.

The invention discloses a health-care food with functions of improving skin moisture and reinforcing immunity. The health-care food comprises the following components in percentage by weight: 1.0 to 80.0 percent of collagen peptide powder, 0.1 to 40.0 percent of glucosamine, 0.1 to 30.0 percent of aloe extract, 0.1 to 50.0 percent of vitamin C (ascorbic acid), and 0.0 to 90.0 percent of auxiliarymaterials. The health-care food can be made into tablets, powder, particles, hard capsules, soft capsules, oral liquids and other oral preparations with various flavors. By virtue of a scientific formula, the raw materials with exact efficacies are compatible reasonably, the collagen peptide powder, the glucosamine, the aloe extract and the vitamin C (ascorbic acid) are selected as main raw materials, and the corresponding auxiliary materials can be selected according to different oral preparations. Furthermore, the selection, purchase, preparation and other aspects of the raw materials are completely operated according to related regulations of health-care foods, so the advancement and stability of the product are ensured; and the health-care food is safe, efficient and stable, and has controllable quality by adopting a modern preparation process matched with a strict quality control method. Toxicological safety tests and function tests prove that the health-care food can be used foreffectively improving the human skin moisture and reinforcing the human body immunity.

The invention discloses a composition for reducing bone loss and a preparation method thereof. The composition is prepared from a calcium compound, marine fishbone collagen oligopeptide powder, glucosamine hydrochloride, casein phosphopeptides, natural vitamin E, vitamin C, vitamin K1, vitamin B12, vitamin D3 and dietary fiber. As proved by animal and human body tests, the composition has the effects of increasing bone density, enhancing bone intensity, reducing bone loss, delaying aging and enhancing the immunity, and can be taken by the middle-aged and old as a health-care food for a long time. The preparation method is scientific and reasonable, and is suitable for industrial production.

Methods for reducing chronic pain caused by a disrupted spinal disc are described. In one method, a physiologically acceptable amount of an injectable is injected into the disc. The injectable is obtained from a stock solution comprising chondroitin sulphate, glucosamine HCl, aqueous solution of dextrose; sodium carboxymethylcellulose, and a buffer substance in quantity to bring the pH of the stock solution to a value above about 6.0. Water is also added to dilute the stock solution. The stock solution may further comprise an anesthetic such as bupivicaine.

A health-care food for increasing human bone density is proportionally prepared from shark cartilage powder, Ca supplement, VD, epimedium, aminoglucose D-hydrochloride, and chondroitin sulfate. Its preparing process is also disclosed.

The invention belongs to the field of monosaccharide component analysis, and in particular relates to a method for detecting monosaccharide components in rainbow conk glycopeptide. The method comprises the following steps of: carrying out a test on HPLC (High Performance Liquid Chromatography) chromatographic condition and systematic compatibility; subsequently respectively absorbing a mixed reference solution and a test solution to be injected into the HPLC chromatographic instrument so as to obtain a chromatogram, wherein the reference solution is a 1phenyl-3-methyl-5-pyrazolone derivative solution of D-glucose, D-mannose, D-xylose, L-xylose, D-galactose, D-arabinose, D-hydrochloric acid glucosamine and L-rhamnose reference solutions; and the test solution is a 1-phenyl-3-methyl-5-pyrazolone derivative solution of a rainbow conk glycopeptide acid hydrolysis product. Polysaccharide peptide products such as rainbow conk glycopeptide, rainbow conk intracellular glycopeptide, rainbow conk extracellular glycopeptides and coriolus versicolor polysaccharide are distinguished by detecting the mole ratio of eight monosaccharide ingredients in a test sample, so that the quality and the curative effect of the rainbow conk glycopeptide are ensured.

The invention relates to a pharmaceutical composition for the treatment of osteoarthritis, the composition of the invention consists of 5 to 10 weight parts of glucosamine hydrochloride, 5 to 10 weight parts of sodium chondroitin sulfate and 1 to 4 weight parts of sodium hyaluronate, and the needed oral formulation can be prepared by adopting the conventional preparation technology along with acceptable excipients in pharmacy. The pharmaceutical composition of the invention has the functions of prevention and treatment of osteoarthritis, so the invention can be used in the preparation of the drugs for the prevention and treatment of osteoarthritis and can also be used as the health care food which has the function of prevention of osteoarthritis.

The invention discloses a preparation method for preparation containing glucosamine and an application thereof. The preparation is characterized in that the major component is one or the combination of more of the glucosamine, glucosamine hydrochloride, glucosamine sulfate sodium chloride double salt or potassium chloride double salt, and chondroitin sulfate. The preparation method is simple, convenient and time-saving to operate and is easy for large industrialized production.

The invention is an ingestible wellness one time daily dosage made of a large quantity of rapid absorbing glucosamine sulfate, glucosamine hydrochloride, and an n-acetyl glucosamine and combinations thereof, a large quantity of chondroitin sulfate, chondroitin hydrochloride and combinations thereof, a vasodialating sulfonate with at least one methyl group, and a buffer to reduce adverse symptoms from large amounts of glucosamine and chondroitin selected from the family of araliaceae and a B3 vitamin, wherein the invention is also a wellness beverage that involves a fluid combined with the ingestible wellness dosage.

The invention provides a traditional Chinese medical health-care preparation for increasing bone density. The traditional Chinese medical health-care preparation comprises the components in parts by weight as follows: 180-310 parts of bovine-derived power, 330-460 parts of herba epimedii, 240-340 parts of dodder, 200-300 parts of glossy privet fruit, 500-700 parts of the fruit of Chinese wolfberry, 180-260 parts of ginseng and 70-120 parts of glucosamine hydrochloride. Based on bovine-derived power, dodder, the fruit of Chinese wolfberry and glossy privet fruit as main raw materials, the raw materials of the preparation proved by modern researches have the function of increasing the bone density, and are matched with appropriate assistant materials to prepare health-care food, so as to improve and relieve osteoporosis and feat fracture caused by decrease of bone density by increasing the bone density. The product verified by toxicological evaluation of health-care food safety is safe and nontoxic, and can be taken for a long time; the product verified by animal function test has the function of increasing the bone density; and the product verified by hygienic, stability and functional component examination is stable and controllable in quality.

The invention relates to a medicine compound, comprising medical active components of chondroitin sulfate, hydrochloric acid aminoglucose, calcium hydrogen orthophosphate and medical acceptable findings. The consumption of hydrochloric acid aminoglucose is 125-1500mg in every dosage agent, chondroitin sulfate is 100-1200mg, and calcium hydrogen orthophosphate is 40-500mg (calculated by calcium). The invention can not only prevent and treat senile ostarthritis, but also replenish the calcium and phosphorus, and the absorption is good, and will not cause side effect such as calcemia or calcium toxic because of high calcium concentration.

A medicinal composition in the form of tablet, capsule, dispersing tablet, effervescent tablet, etc for treating the various osteoarthritides is prepared from aminoglucose hydrochloride, chondroitin sulfate and pharmacologically acceptable additives.

An effervescent tablet of compound aminoglucose sulfate / chondroitin sulfate for treating osteoarthritis is prepared from the aminoglucose sulfate, chondroitin sulfate (or its Na salt), and the pharmacologically acceptable additive. Its preparing process is also disclosed.

A topical composition for anti-aging and anti-UV damage treatment of the skin includes water soluble extract of Uncaria species, Arabidopsis thaliana extract, alpha lipoic acid, dimethylethanolamine, tetrahexyldecyl ascorbate, dimethyl sulfoxide, Glycyrrhiza Glabra (licorice) root extract, methylsulfonylmethane, phytosterols, D-ribose, tocotrienol, tocopherol, glucosamine hydrochloride, Pisum sativum extract; silicates of sodium, magnesium and aluminum, and a dermatologically acceptable liposomal delivery medium. The composition is useful in a method using it for anti-aging skin treatment effecting DNA repair in both the nucleus and the mitochondria. The topical composition can be applied on the skin of a person daily, and can also be applied in a dermal infusion treatment, with or without micro-dermal abrasion or skin suction. Topical application of the composition achieves effective reduction of pigmentation spots, degree of winkles, and improvement of skin color, tone and turgidity, particularly of the eyelid and facial areas.

The invention relates to an oral liquid composition for improving osteoarthritis and a preparation method thereof. Each milliliter of the composition comprises the following raw material components: 40-60mg of glucosamine hydrochloride, 30-50mg of chondroitin sulfate, 2-3mg of an organic acid, 1-3mg of an antiseptic, 0.2-0.4mg of a suspending aid, and a proper amount of a sweetener. The preparation method comprises the following steps: 1, dissolving chondroitin sulfate, the organic acid, the sweeter, the antiseptic, and the suspending aid in distilled water to obtain a solution, controlling the temperature of the solution at 30-50DEG C, accessing nitrogen for 10min, adding glucosamine hydrochloride, stirring to complete dissolving, determining the pH value and the content, filling nitrogen, bulking, capping, and sealing. By adopting the components and the method of the invention, a clear liquid preparation with a good stability and completely dissolved medicines can be prepared, and the taste of the preparation can be accepted by patients.

The invention discloses a glucosamine gel, comprising the following components in percentage by weight: 0.25-5.0 percent of glucosamine hydrochloride or glucosamine sulfate (in the terms of glucosamine), 0.8-4.0 percent of matrix, 25.0-40.0 percent of moisturizer, 1-10.0 percent of skin penetration enhancer, 0-2.0 percent of preservative in which zero is unavailable, 0-6.0 percent of solubilizer in which zero is unavailable, 0-2.0 percent of antioxidant in which zero is unavailable, and the balance of water. The preparation method of the glucosamine gel comprises the following steps of: dissolving glucosamine hydrochloride or glucosamine sulfate in water, adding the other ingredients and stirring till the glucosamine hydrochloride or glucosamine sulfate is dispersed uniformly; regulating a pH value to be 6.0-8.0 and adding water to the total amount; and uniformly stirring to obtain the glucosamine gel. More than 60 percent of glucosamine within 6 hours is released and the glucosamine gel plays roles in administrating medicine at regular point of time and rapidly taking into effect.

The invention discloses a novel preparation method of glucosamine sulfate, and belongs to the field of monosaccharide preparation methods. The novel preparation method adopts glucosamine hydrochloride as a raw material and comprises the following steps of treating a glucosamine hydrochloride aqueous solution by a strongly basic anion exchange resin to remove chloridions to obtain glucosamine; neutralizing the glucosamine by a sulfuric acid solution to obtain glucosamine sulfate; and drying the glucosamine sulfate to obtain a glucosamine sulfate preparation without sodium chloride. Specifically, the steps comprises 1) treating 1-25% (W / V) of the glucosamine hydrochloride aqueous solution by the pre-washed strongly basic anion exchange resin column to remove chloridions, 2) collecting effluent liquid obtained from the step 1), 3) adding 20-90% (W / W) of a sulfuric acid solution into the effluent liquid to obtain a glucosamine sulfate aqueous solution by neutralization, wherein a pH value of the glucosamine sulfate aqueous solution is in a range of 3.5 to 5.0; and 4) carrying out a freeze drying process on the glucosamine sulfate aqueous solution, or precipitating the glucosamine sulfate aqueous solution by an organic solvent and then carrying out vacuum drying to obtain a glucosamine sulfate preparation without sodium chloride. The novel preparation method has the advantages of simple process, low cost, less three-waste, and no pollution in production.

An injectable for injection into a spinal disc, and a method to treat a spinal disc with the injectable. The injectable consists essentially of chondroitin sulfate and glucosamine HCl buffered to a pH above about 6.0.

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

An animal toy containing food having a first portion with food delivery means integrated therein adapted to securely house solid food treats, including a nutritional pet supplement, to be removed by the animal during play or through chewing action, and a second side with a plurality of gum stimulation teeth integrated within and projecting therefrom that act to massage the gums of the animal. Food delivery means may be provided as a plurality of cavities integrated within the first portion (and optionally, the second portion), preferably having a grooved or threaded interior for securely holding food pieces securely therein. Alternatively, the food delivery means is provided as a food portion composing the first portion. A pet supplement may be utilized, including joint preserving and joint rebuilding compositions comprising chicken collagen type II, glucosamine hydrochloride and chondroitin sulfate, a vitamin composition comprising vitamins C, D and K, a mineral composition comprising calcium, magnesium, zinc, copper, manganese and boron, a herbal anti-oxidant cofactor blend comprising citrus bioflavonoids, red grapes anthocyanins, turmeric rhizome, boswellia resin and fennel seed.

The invention discloses a health-care food having the function of increasing the density of bones. The health-care food is prepared by the active components comprising radix astragali, cortex eucommiae, rhizoma drynariae, glucosamine hydrochloride, soy isoflavones and collagen protein. The health-care food of the invention is characterized by combining traditional Chinese medicinal herb features with modern medical research, thus causing various components to be prescribed reasonably and to be matched with each other for sharing and achieving the health care function by various approaches and multiple layers.

A pet supplement includes a joint preserving and joint rebuilding composition comprising chicken collagen type II, glucosamine hydrochloride and chondroitin sulfate, a vitamin composition comprising vitamins C, D and K, a mineral composition comprising calcium, magnesium, zinc, copper, manganese and boron, a herbal anti-oxidant cofactor blend comprising citrus bioflavonoids, red grapes anthocyanins, turmeric rhizome, boswellia resin and fennel seed. Each of these ingredients is intimately mixed into the pet supplement and orally delivered to the pet in the form of a segment, paste or powder having a size and weight or other dosage measuring feature adjusted in accordance with the pet's weight. A synergistic action between these ingredients preserves and rebuilds the pet's joints, and is nutritionally beneficial for the pet.

The invention relates to a chitosan-containing health composition to increase bone density and application thereof and belongs to the field of medicine. The chitosan-containing health composition to increase bone density is prepared from, by weight, 2-6 parts of chitosan, 10-50 parts of chondroitin sulfate, 10-50 parts of glucosamine hydrochloride, 10-20 parts of hyaluronic acid, 10-50 parts of milk minerals, 10-20 parts of colostrum basic protein, and 20-100 parts of collagen peptide. The components provide significant synergy to increase bone intensity and is suitable for popularization andapplication.

The invention discloses a health product for improving physical performance and increasing bone mineral density. The product is prepared from the following raw materials and auxiliary materials in parts by weight: 20-40 parts of calcium source, 20-40 parts of glucosamine hydrochloride, 10-30 parts of chondroitin sulfate, 10-30 parts of oligopeptide, 5-20 parts of microcrystalline cellulose, 1-10 parts of carboxymethyl starch sodium, 300.2-0.4 part of povidone K, 0.1-0.5 part of hydroxypropyl methylcellulose, 0.8-1.2 part of magnesium stearate, and 0 or 1-10 parts of other auxiliary materials. The health product disclosed by the invention has the following advantages: (1) the product has fast effect after being taken, and the physical performance can be quickly recovered after intense exercise, the body pain and fatigue feeling can be reduced; (2) the oligopeptide can quickly repair the injury, enhance the muscle strength, relieve and prevent the inconvenience caused by insufficient muscle strength; (3) the product can increase the bone mineral density of the body after being taken, the combination of the bone-strengthening and the muscle-strengthening elements can improve the physical performance of the middle aged and elderly people from the root, the middle aged and elderly people can move freely and is full of energy.

The invention relates to a quick and effective method for preparing glucosamine sulfate potassium chloride compound salt. The method is characterized by comprising the following steps of: treating anion resin by using 10 percent sulfuric acid solution, and preparing glucosamine hydrochloride solution; making the glucosamine hydrochloride solution pass through a column at a flow rate of 500mL / H, and performing metathesis to obtain glucosamine sulfate; slowly adding potassium chloride, performing metathesis with the obtained glucosamine sulfate solution, and performing reflux reaction in a molar ratio of 2:1 at the temperature of between 45 and 65DEG C for 24 hours; distilling the refluxed glucosamine sulfate potassium chloride solution under reduced pressure at the temperature of between 50 and 60DEG C until the distilled glucosamine sulfate potassium chloride solution is 40 to 50 percent of the total solution; and performing centrifugal dehydration and vacuum drying on the distilled glucosamine sulfate potassium chloride compound salt; and detecting and packaging the finished product. The quick and effective method overcomes defects that personnel are harmed and environment is polluted because an organic solvent is adopted for freeze drying in the prior art, and saves a large amount of operating cost.

The invention discloses a content detection method for glucosamine hydrochloride capsules. The method adopts a high performance liquid chromatograph and evaporative light-scattering detection method; a chromatographic column is a DIKMAC18 column of 5 micrometers with the specification of 200mm*4.6mm; a mobile phase consists of acetonitrile and water; the flow velocity of 0.1% of trifluoroacetic acid is 0.55-0.65ml / min; the temperature of the column is 30 DEG C; an Alltech ELSD 2000 detector is adopted; the temperature of a drift tube is 65-75 DEG C; and the pressure of an air pump is 0.24-0.28Mpa. A reference substance stock solution, a test solution and a negative auxiliary material solution are absorbed and then injected into a liquid chromatograph, a chromatogram map is recorded, a sample size log value is expressed as X, the corresponding peak area log value is expressed as Y, and linear fitting is conducted to obtain an equation of linear regression with the range of linearity between 0.8mg / ml to 1.2mg / ml.

The resent invention relates to a cream composition of glucosamine, including at least 10 wt %-15 wt % of glucosamine HCL, a methylsulfonylmethane component, a chondroitin component, and a cream base, wherein the composition promotes penetration of glucosamine from skin of affected area by synergistic interaction between components, in order to enhance absorption of human body.

A preparation for increasing the calcium absorption, which is provided by the invention, relates to a calcium supplement product, in particular to a preparation which can supplement calcium. The calcium supplement preparation of the invention is mainly prepared by main raw materials of calcium acetate, glucosamine hydrochloride, CPPs, extracts of epimedium and extracts of rhizoma drynariae, and is characterized in that the ratio of the main raw materials is 5 portions to 40 portions of calcium acetate, 1 portion to 20 portions of glucosamine hydrochloride, 0.5 portion to 3 portions of CPPs, 1 portion to 5 portions of extracts of epimedium, 1 portion to 5 portions of extracts of rhizoma drynariae and 0.1 portion to 25 portions of auxiliary material. The preparation of the invention can realize the effects of promoting calcium absorption, improving bone metabolism and bone nutrition and increasing the bone density.

The invention relates to the technical field of a health care product, and in particular provides a health care product capable of improving bones and joints and a preparation method of the health care product, wherein the health care product is mainly prepared from the following raw materials in parts by weight: as for active ingredients: 10-40 parts of calcium carbonate, 15-40 parts of chitosamine hydrochloride and 10-30 parts of chondroitin sulfate, and as for accessories: 0.1-1 part of glucose essence and 1-5 parts of a thin-film coating agent. The preparation method of the health care product capable of improving bones and joints comprises five steps, namely preparing powder, mixing, granulating, mixing materials and tabletting, and coating. The health care product provided by the invention is high in calcium content, good in effect and good in absorption, and the health care product, by supplementing calcium and promoting osteoblastic cell proliferation, has a function of enhancing bone density so as to take better effects on preventing and improving osteoporosis and improving life level of middle aged and elderly people; and the health care product is low in cost and is applicable to extensive popularization and application. The preparation method of the health care product provided by the invention is simple and efficient, high in active ingredient utilization rate and suitable for industrial popularization.