Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of glucosamine and gel, applied in the field of glucosamine gel preparation and its preparation, can solve the problems of long onset period, inconvenient administration, etc. Effect
Active Publication Date: 2012-08-01
裕松源药业有限公司
View PDF4 Cites 8 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] In order to overcome the problems of inconvenient administration and long onset period of the existing glucosamine dosage form, the present invention provides an external dosage form of glucosamine dosage form, which is convenient to use and has a fast onset of effect
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0034] Take 6Kg of purified water, add glucosamine hydrochloride (calculated as glucosamine) 20g, L-cysteine 8g, stir to dissolve. Take 64g of Carbomer 980NF, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 8g of Tween-80, 80g of sodium lauryl sulfate, 2.0L of 1,2-propylene glycol, and 0.01g / mL of paraben Methyl ester ethanol solution 400mL, stir until mixed evenly, adjust pH to 7.0 with triethanolamine, add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.
Embodiment 2
[0036] Take 6Kg of purified water, add glucosamine sulfate (calculated as glucosamine) 200g, sodium sulfite 80g, stir to dissolve. Take 160g of carbomer 980NF, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 80g of Tween-80, 160g of dimethylacetamide, 2.2L of 1,2-propanediol, and 8g of potassium sorbate, and stir Mix until uniform, adjust the pH to 7.0 with triethanolamine, and add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.
Embodiment 3
[0038] Take 6Kg of purified water, add glucosamine hydrochloride (calculated as glucosamine) 400g, L-cysteine 160g, stir to dissolve. Take carbomer 980NF 320g, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 240g of Tween-80, 480g of oleic acid, 2.4L of 1,2-propanediol, and 80g of chlorobutanol, and stir until Mix well, adjust pH to 7.0 with triethanolamine, add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a glucosamine gel, comprising the following components in percentage by weight: 0.25-5.0 percent of glucosamine hydrochloride or glucosamine sulfate (in the terms of glucosamine), 0.8-4.0 percent of matrix, 25.0-40.0 percent of moisturizer, 1-10.0 percent of skin penetration enhancer, 0-2.0 percent of preservative in which zero is unavailable, 0-6.0 percent of solubilizer in which zero is unavailable, 0-2.0 percent of antioxidant in which zero is unavailable, and the balance of water. The preparation method of the glucosamine gel comprises the following steps of: dissolving glucosamine hydrochloride or glucosamine sulfate in water, adding the other ingredients and stirring till the glucosamine hydrochloride or glucosamine sulfate is dispersed uniformly; regulating a pH value to be 6.0-8.0 and adding water to the total amount; and uniformly stirring to obtain the glucosamine gel. More than 60 percent of glucosamine within 6 hours is released and the glucosamine gel plays roles in administrating medicine at regular point of time and rapidly taking into effect.
Description
technical field [0001] The invention relates to a glucosamine gel preparation and a preparation method thereof. The gel preparation can be used externally to repair and maintain articular cartilage, relieve joint pain, and has convenient administration and remarkable effect. Background technique [0002] Glucosamine, formula C 6 h 13 o 5 N, is the structural unit of cartilage extracellular matrix glycosaminoglycan, hyaluronic acid, and is a natural tissue component of healthy articular cartilage. The main functions of glucosamine as bone and joint medicine are: 1. Repair (or repair) the worn articular cartilage and its surrounding soft tissue, so as to keep the articular surface smooth; 2. Promote the generation of more "synovial fluid" between joints, thereby It can reduce the friction between joints when walking; 3. Anti-inflammatory effect; 4. It has obvious effect and no toxic side effects. The salts of glucosamine include glucosamine hydrochloride and glucosamine s...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more