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Medicinal composition for treating senile osteoarthropathy

A technology for osteoarthropathy and a composition is applied in the field of pharmaceutical compositions for preventing and treating senile osteoarthritis, and can solve the problems of unsatisfactory curative effect, poor absorption of calcium source, easy oxidation and discoloration of amino groups, etc. Treatment of senile osteoarthritis, repair and enhancement of articular cartilage, good absorption and utilization

Inactive Publication Date: 2007-10-24
芜湖中加生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For glucosamine sulfate, the effective part is only glucosamine, and there are many disadvantages as a drug, such as glucosamine sulfate is highly hygroscopic, and its amino group is easily oxidized and discolored; for the calcium source, Wu Jing from the Health Education Department of Beijing Friendship Hospital In a report entitled "How to Supplement Calcium Scientifically", it is written that "the absorption rate of calcium carbonate, calcium lactate, and calcium gluconate is 30%-80%", which shows that the absorption of calcium sources in the above patent application is not good , and calcium gluconate, calcium lactate, etc. will produce some side effects due to excessive blood calcium concentration, such as hypercalcemia syndrome or calcium poisoning, so the curative effect of the pharmaceutical composition composed of the above calcium source, ammonia glucosamine and chondroitin cannot satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] [Example 1] Tablets of Glucosamine Hydrochloride, Chondroitin Sulfate and Calcium Hydrogen Phosphate

[0044] prescription:

[0045] Glucosamine Hydrochloride 375g

[0046] Chondroitin Sulfate 300g

[0047] Calcium hydrogen phosphate (calculated as calcium) 150g

[0048] Cross-linked polyvinylpyrrolidone 50g

[0049] Proper amount of ethanol

[0050] Micronized silica gel 10g

[0051] Magnesium Stearate 10g

[0052] Makes 1000 pieces

[0053] Coating part:

[0054] Hydroxypropyl methylcellulose (5cps) 16g

[0055] Macrogol 400 4g

[0056] Talc powder 4g

[0057] Ethanol 400ml

[0058] Coating weight gain 2% ~ 3%

[0059] Preparation method: Mix chondroitin sulfate, glucosamine hydrochloride, calcium hydrogen phosphate and 1 / 2 amount of cross-linked polyvinylpyrrolidone evenly, granulate with an appropriate amount of ethanol, pass through a 40-mesh sieve, dry with hot air, and granulate. Add the remaining c...

Embodiment 2

[0060] [Example 2] Tablets of Glucosamine Hydrochloride, Chondroitin Sulfate and Calcium Hydrogen Phosphate

[0061] prescription:

[0062] Glucosamine Hydrochloride 375g

[0063] Chondroitin Sulfate 300g

[0064] Calcium hydrogen phosphate (calculated as calcium) 430g

[0065] Cross-linked polyvinylpyrrolidone 50g

[0066] Proper amount of ethanol

[0067] Micronized silica gel 10g

[0068] Magnesium Stearate 10g

[0069] Makes 1000 pieces

[0070] The coating part and preparation method are the same as in Example 1.

Embodiment 3

[0071] [Example 3] Tablets of Glucosamine Hydrochloride, Chondroitin Sulfate and Calcium Hydrogen Phosphate

[0072] prescription:

[0073] Glucosamine Hydrochloride 125g

[0074] Chondroitin Sulfate 1200g

[0075] Calcium hydrogen phosphate (calculated as calcium) 40g

[0076] Cross-linked polyvinylpyrrolidone 50g

[0077] Proper amount of ethanol

[0078] Micronized silica gel 10g

[0079] Magnesium Stearate 10g

[0080] Makes 1000 pieces

[0081] The coating part and preparation method are the same as in Example 1.

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PUM

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Abstract

The invention relates to a medicine compound, comprising medical active components of chondroitin sulfate, hydrochloric acid aminoglucose, calcium hydrogen orthophosphate and medical acceptable findings. The consumption of hydrochloric acid aminoglucose is 125-1500mg in every dosage agent, chondroitin sulfate is 100-1200mg, and calcium hydrogen orthophosphate is 40-500mg (calculated by calcium). The invention can not only prevent and treat senile ostarthritis, but also replenish the calcium and phosphorus, and the absorption is good, and will not cause side effect such as calcemia or calcium toxic because of high calcium concentration.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating senile osteoarthropathy, in particular to a pharmaceutical composition composed of glucosamine hydrochloride, chondroitin sulfate and calcium hydrogen phosphate. Background technique [0002] Osteoarthritis is the most common joint disease among the elderly. Osteoarthritis is also known as degenerative arthritis and bone hyperplasia. The common symptoms are pain in the affected joints, aggravated by activities, relief after rest, and stiffness after prolonged inactivity. China has entered the ranks of countries with an aging population in the world, and the elderly population in Beijing has reached 13%, so the incidence of senile diseases is also gradually increasing. In foreign surveys, the incidence rate is generally no more than 5% among people under the age of 25, but more than 90% of people over the age of 80 have it. [0003] With the increase of age, the human bod...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K9/14A61K9/16A61K9/20A61K9/46A61K9/48A61P19/02A61K31/7008A61K31/737
Inventor 张智凯
Owner 芜湖中加生物制药股份有限公司
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