Quick and efficient method for preparing glucosamine sulfate potassium chloride compound salt

A technology of glucosamine sulfate and glucosamine hydrochloride, which is applied to the preparation of amino sugar and sugar derivatives, chemical instruments and methods, etc., can solve the problems of large energy consumption, high operating costs, organic solvent environment and personnel hazards, and achieve Energy saving and running cost saving effects

Inactive Publication Date: 2011-08-31
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The above method uses acetone as a solvent to freeze-dry to prepare glucosamine sulfate. The organic solvent is harmful to the environment and personnel and the...

Method used

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  • Quick and efficient method for preparing glucosamine sulfate potassium chloride compound salt
  • Quick and efficient method for preparing glucosamine sulfate potassium chloride compound salt
  • Quick and efficient method for preparing glucosamine sulfate potassium chloride compound salt

Examples

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Embodiment 1

[0042] Fast, efficient preparation method of glucosamine sulfate potassium chloride double salt, is characterized in that following steps realize:

[0043] A, process anion resin with 10% sulfuric acid solution, during sulfation, it will be continuously processed three times to make it contain saturated sulfate radical;

[0044] B, the preparation of glucosamine hydrochloride solution: wherein the concentration weight ratio of glucosamine hydrochloride solution is 10%;

[0045] C, passing through the column: the glucosamine hydrochloride solution is passed through the column at a flow rate of 500ml / H, and the glucosamine sulfate is replaced;

[0046] D. Slowly add potassium chloride to the glucosamine sulfate solution obtained by replacement, and carry out reflux reaction at a molar ratio of 2:1 for 24 hours, at a temperature of 45-65°C;

[0047] E, the backflow glucosamine sulfate potassium chloride solution is distilled under reduced pressure, at a temperature of 50-60°C, d...

Embodiment 2

[0055] Glucosamine Sulfate Potassium Chloride is a kind of bone and joint nutrition supplement which is very popular in the world, which is prepared from glucosamine hydrochloride and potassium sulfate as raw materials. Many countries have approved it as a medicine for treating bone and joint diseases. The U.S. FDA listed it in the Pharmacopoeia as early as 1995, the European Union listed it in the Pharmacopoeia in 1999, and my country also established the drug standard for glucosamine sulfate potassium chloride in 2003. It can be said that glucosamine sulfate potassium chloride has become the most popular medicinal and food homologous substance in the world after vitamins. Yet find according to our research of nearly two years, have two kinds with glucosamine hydrochloride and potassium sulfate preparation and meet U.S. FDA standard, EU standard and my country's national drug standard glucosamine sulfate potassium chloride: a kind of is ion exchange method (the present inventi...

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Abstract

The invention relates to a quick and effective method for preparing glucosamine sulfate potassium chloride compound salt. The method is characterized by comprising the following steps of: treating anion resin by using 10 percent sulfuric acid solution, and preparing glucosamine hydrochloride solution; making the glucosamine hydrochloride solution pass through a column at a flow rate of 500mL/H, and performing metathesis to obtain glucosamine sulfate; slowly adding potassium chloride, performing metathesis with the obtained glucosamine sulfate solution, and performing reflux reaction in a molar ratio of 2:1 at the temperature of between 45 and 65DEG C for 24 hours; distilling the refluxed glucosamine sulfate potassium chloride solution under reduced pressure at the temperature of between 50 and 60DEG C until the distilled glucosamine sulfate potassium chloride solution is 40 to 50 percent of the total solution; and performing centrifugal dehydration and vacuum drying on the distilled glucosamine sulfate potassium chloride compound salt; and detecting and packaging the finished product. The quick and effective method overcomes defects that personnel are harmed and environment is polluted because an organic solvent is adopted for freeze drying in the prior art, and saves a large amount of operating cost.

Description

technical field [0001] The invention relates to a fast and efficient preparation method of glucosamine sulfate potassium chloride double salt. Background technique [0002] Glucosamine is a natural amino monosaccharide that exists in the human body, especially in articular cartilage. It is the basic substance for the synthesis of aminoglycans and a component of proteoglycans in articular cartilage. It can specifically act on articular cartilage, restore the normal metabolic function of chondrocytes, stimulate chondrocytes to produce proteoglycans with normal multimeric structure, maintain the morphology and structure of cartilage matrix, and inhibit the hyperactivity of type II collagen in damaged cartilage matrix. Oxidative free radicals, collagenase and phospholipase A2 generation; inhibit the synthesis of prostaglandins, protect corticosteroids and other harmful substances from destroying chondrocytes, thereby delaying the pathological process and disease progression of b...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/00A61P29/00A61P19/02
Inventor 尹鸿萍王莹聂煜刘敏缪小亮王旻梁双林彭秀兰沈妙根
Owner CHINA PHARM UNIV
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