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Oral liquid composition for improving osteoarthritis and preparation method thereof

A technology of liquid composition and solution, which is applied in the direction of drug combination, medical preparations containing active ingredients, bone diseases, etc. It can solve the problems of aggregation and precipitation, difficulty in obtaining liquid preparations, etc., and achieve the effect of reliable quality and curative effect

Inactive Publication Date: 2012-02-08
山东泰洋树生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large molecular weight of chondroitin sulfate, it is easy to aggregate and precipitate in the solution, and it is difficult to obtain a stable liquid preparation by conventional solution preparation methods.

Method used

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  • Oral liquid composition for improving osteoarthritis and preparation method thereof
  • Oral liquid composition for improving osteoarthritis and preparation method thereof
  • Oral liquid composition for improving osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Embodiment 1: Glucosamine Hydrochloride Chondroitin Sulfate Oral Liquid (1000ml)

[0102] Prescription: Glucosamine Hydrochloride 50g

[0103] Chondroitin Sulfate 40g

[0104] Citric acid 3g

[0105] Stevioside 1g

[0106] Sodium Benzoate 1g

[0107] Potassium sorbate 1g

[0108] Sodium carboxymethylcellulose 0.3g

[0109] Grape essence 1ml

[0110] Carmine 60 0.15g

[0111] Distilled water 950ml

[0112] Preparation method: Dissolve the prescribed amount of chondroitin sulfate, citric acid, stevioside, sodium benzoate, potassium sorbate, and sodium carboxymethylcellulose in 950ml of distilled water, heat and boil for 30 minutes, cool to 30°C, add carmine After 60°C, nitrogen gas was introduced for 10 minutes, glucosamine hydrochloride and grape essence were added, and after stirring and dissolving completely, the pH and content of the intermediate were measured, filled with nitrogen, and sealed with a cover.

Embodiment 2

[0113] Embodiment 2: Glucosamine Hydrochloride Chondroitin Sulfate Oral Liquid (1000ml)

[0114] Prescription: Glucosamine Hydrochloride 40g

[0115] Chondroitin Sulfate 50g

[0116] Citric acid 3g

[0117] Stevioside 1g

[0118] Sodium Benzoate 1g

[0119] Potassium sorbate 1g

[0120] Sodium carboxymethylcellulose 0.3g

[0121] Grape essence 1ml

[0122] Carmine 60 0.15g

[0123] Distilled water 950ml

[0124] Preparation method: Dissolve the prescribed amount of chondroitin sulfate, citric acid, stevioside, sodium benzoate, potassium sorbate, and sodium carboxymethylcellulose in 950ml of distilled water, heat and boil for 30 minutes, cool to 30°C, add carmine After 60°C, nitrogen gas was introduced for 10 minutes, glucosamine hydrochloride and grape essence were added, and after stirring and dissolving completely, the pH and content of the intermediate were measured, filled with nitrogen, and sealed with a cover.

Embodiment 3

[0125] Embodiment 3: Glucosamine Hydrochloride Chondroitin Sulfate Oral Liquid (1000ml)

[0126] Prescription: Glucosamine Hydrochloride 60g

[0127] Chondroitin Sulfate 30g

[0128] Citric acid 3g

[0129] Stevioside 1g

[0130] Sodium Benzoate 1g

[0131] Potassium sorbate 1g

[0132] Sodium carboxymethylcellulose 0.3g

[0133] Grape essence 1ml

[0134] Carmine 60 0.15g

[0135] Distilled water 950ml

[0136] Preparation method: dissolve the prescribed amount of chondroitin sulfate, citric acid, stevioside, sodium benzoate, potassium sorbate, and sodium carboxymethylcellulose in 950ml of distilled water, heat and boil for 25 minutes, cool to 30°C, add carmine After 60°C, nitrogen gas was introduced for 10 minutes, glucosamine hydrochloride and grape essence were added, and after stirring and dissolving completely, the pH and content of the intermediate were measured, filled with nitrogen, and sealed with a cover.

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Abstract

The invention relates to an oral liquid composition for improving osteoarthritis and a preparation method thereof. Each milliliter of the composition comprises the following raw material components: 40-60mg of glucosamine hydrochloride, 30-50mg of chondroitin sulfate, 2-3mg of an organic acid, 1-3mg of an antiseptic, 0.2-0.4mg of a suspending aid, and a proper amount of a sweetener. The preparation method comprises the following steps: 1, dissolving chondroitin sulfate, the organic acid, the sweeter, the antiseptic, and the suspending aid in distilled water to obtain a solution, controlling the temperature of the solution at 30-50DEG C, accessing nitrogen for 10min, adding glucosamine hydrochloride, stirring to complete dissolving, determining the pH value and the content, filling nitrogen, bulking, capping, and sealing. By adopting the components and the method of the invention, a clear liquid preparation with a good stability and completely dissolved medicines can be prepared, and the taste of the preparation can be accepted by patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an oral liquid composition for improving osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis is the most common joint disease among the elderly. Osteoarthritis is also known as degenerative arthritis and bone hyperplasia. The common symptoms are pain in the affected joints, aggravated by activities, relief after rest, and stiffness after prolonged inactivity. China has entered the ranks of countries with an aging population in the world, and the elderly population in Beijing has reached 13%, so the incidence of senile diseases is also gradually increasing. In foreign surveys, the incidence rate is generally no more than 5% among people under the age of 25, but more than 90% of people over the age of 80 have it. [0003] The traditional treatment drugs for osteoarthritis are non-steroidal anti-inflammatory drugs. Lon...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K31/7008A61P19/02A61P19/08
Inventor 张智凯
Owner 山东泰洋树生物工程有限公司
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