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Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof

A technology of glucosamine hydrochloride and chondroitin sulfate, which is applied to effervescent tablets and their preparation methods, uses, and can solve the problems of large tablets that are difficult to swallow and large proportions of main ingredients

Inactive Publication Date: 2007-04-18
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The main ingredients in this compound preparation can be dissolved in water, and can be dissolved while the tablet is effervescent to obtain a clear solution; moreover, the specification of this compound preparation is relatively large, 500mg+400mg, and the proportion of main ingredients is large, so it can be compressed into ordinary tablets Dosage will cause the tablet volume to be too large and difficult to swallow or the inconvenience of taking multiple tablets at a time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation:

[0024] Pass glucosamine hydrochloride and sodium chondroitin sulfate through a 100-mesh sieve, mix evenly, add the prescribed amount of sodium bicarbonate, citric acid, sweet orange essence, PEG6000, mix well, select a suitable die, and use the powder to directly compress the tablet Tablets can be obtained by pressing.

Embodiment 2

[0027] Preparation:

[0028] Pass glucosamine hydrochloride and chondroitin sulfate through 80 mesh sieve respectively, take glucosamine hydrochloride and add half amount (100g) of sucrose, mix evenly with tartaric acid, use 1% pvp-k30 aqueous solution to make soft material, granulate with 18 mesh sieve, dry, 16 mesh sieve for granulation, and set aside; take chondroitin sulfate plus the balance of sucrose (100g), mix it with sodium bicarbonate evenly, use 1% pvp-k30 aqueous solution to make soft material, granulate with 18 mesh sieve, dry, 16 mesh Sieve the granules for later use; mix the above two granules, add grape essence and magnesium stearate, mix thoroughly, and press into tablets to obtain the product.

Embodiment 3

[0031] Preparation:

[0032] Pass glucosamine hydrochloride, chondroitin sulfate, xylitol, sodium carbonate, sodium bicarbonate, sweet orange essence, and aspartame through 80-mesh sieve respectively, after mixing evenly, add an appropriate amount of absolute ethanol solution to make soft material, 16-mesh Sieve to granulate, dry, sieve through a 12-mesh sieve for granulation, add micropowder silica gel, mix evenly, and press into tablets to obtain the product.

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PUM

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Abstract

An effervescent tablet of compound aminoglucose sulfate / chondroitin sulfate for treating osteoarthritis is prepared from the aminoglucose sulfate, chondroitin sulfate (or its Na salt), and the pharmacologically acceptable additive. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an effervescent tablet with glucosamine hydrochloride and chondroitin sulfate as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Osteoarthritis is a degenerative chronic joint disease. The clinical manifestations are pain, swelling, and limited movement of the affected joints. In advanced patients, symptoms and signs such as cartilage spalling, bone spur formation, and subchondral osteonecrosis may appear, resulting in loss of joint function. , Severe cases must undergo artificial joint conversion surgery. [0003] Glucosamine is an amino monosaccharide, and chondrocytes usually use glucose to synthesize glucosamine. Supplementing exogenous glucosamine, in addition to providing the precursors of disaccharide units for the synthesis of glycosaminoglycans in vivo, in vitro studies have found that glucosamine can stimulate chondrocytes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/7008A61K9/46A61P19/02
Inventor 严轶东
Owner FUKANGREN BIO PHARMA
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