The invention relates to novel compounds, a preparation method and use thereof, in particular to halogenated hydroxyl aromatic
methane compounds, a preparation method and use thereof, which solves the problem that halogenated hydroxyl aromatic
methane lead compounds from natural sources are high in extraction cost, low in yield and difficult to develop follow-up study. The compounds have a
structural formula, wherein R1' is one or more hydroxyl or
hydrogen atoms in any position on an A ring; R2' is one or more hydroxyl or
hydrogen atoms in any position on a B ring; and X is one or more
halogen or
hydrogen atoms in any position on the A ring or the B ring. A synthesis method has the advantages of mild
reaction conditions, widely readily available raw materials, simple preparation method, high yield, low cost and the like, and is suitable for industrial production. The synthesized halogenated hydroxyl aromatic
methane compounds and non-toxic salts, ester and
ether thereof have the activity of resisting
bacteria, tumors, oxidation and vascular endothelial
cell injury and inhibiting proliferation of
vascular smooth muscle cells.