34 results about "Cysteine synthesis" patented technology

Disclosed is a homocysteine synthase inhibitor which is useful for the prevention or treatment of a disease associated with homocysteine synthase. Specifically disclosed is a compound represented by general formula (I) [wherein each symbol is as defined in the description], a pharmacologically acceptable salt of the compound, or a solvate of the compound or the pharmacologically acceptable salt, which can be used as the homocysteine synthase inhibitor.

The present invention describes an approach to produce taurine or increase hypotaurine or taurine production in prokaryotes or eukaryotes. More particularly, the invention relates to genetic transformation of organisms with algal, microalgal or fungal genes that encode proteins that pool catalyze the conversion of sulfur-containing compounds such as sulfate or cysteine to taurine. The invention describes methods for the use of polynucleotides for cysteine dioxygenase-like (CDOL), sulfmoalanine decarboxylase-like (SADL), cysteine sulfate / decarboxylase or a portion of the cysteine synthetase / PLP decarboxylase (partCS / PLP-DC) polypeptide in bacteria, alga, yeast, or plants to produce taurine or increase hypotaurine or taurine. The preferred embodiment of the invention is in plants but other organisms may be used. Taurine production or increased levels of hypoataurine or taurine in plants could be used as nutraceutical, pharmaceutical, or therapeutic compounds or as a supplement in animal feed or for animal feed or as an enhancer for plant growth or yield

The invention discloses a method for extracting glutathione. The method includes adding water, adenosine triphosphate, Y--glutamic acid and cysteine synthase GSH I into L-glutamic acid, L-cysteine and glycine which are used as substrates, carrying out catalysis, adding glutathione synthase GSH II into the substrates, carrying out catalysis, carrying out two-step reaction to obtain mixed solution with glutathione, the Y--glutamic acid and cysteine synthase and the glutathione synthase, separating the glutathione, the Y--glutamic acid and cysteine synthase and the glutathione synthase from one another to obtain low-concentration glutathione aqueous solution, the Y--glutamic acid and cysteine synthase and the glutathione synthase and allowing the Y--glutamic acid and cysteine synthase and the glutathione synthase to return systems to be reuse; carrying out low-pressure reverse osmosis concentration and high-pressure reverse osmosis concentration on the obtained low-concentration glutathione aqueous solution, then adding absolute ethyl alcohol into the glutathione aqueous solution, carrying out alcohol-precipitation crystallization on the glutathione aqueous solution to ultimately obtain glutathione products and recycling and reusing ethyl alcohol solution. The method has the advantages that high-concentration glutathione solution can be obtained by the aid of the method, the usage of the absolute ethyl alcohol can be reduced during alcohol-precipitation crystallization, energy consumption and the production cost can be decreased, the yield can be increased, the productivity can be improved, wastewater and waste gas can be prevented in production procedures, and accordingly the method is an environment-friendly, green and efficient production process.

The invention belongs to the intermediate field of pharmaceutical chemical industry, and relates to a preparation method for synthesizing a diaryl thioether compound based on L-cysteine. The method comprises the following steps: under the protection of inert gas, adding substituted iodobenzene and L-cysteine into an aprotic polar solvent, then adding a copper salt catalyst and alkali, and reacting at 100-150 DEG C for 6-24 hours to obtain the diaryl thioether compound. The method has the advantages of simple and mild reaction conditions, safety, no toxicity, low price, simplicity and convenience in operation, good functional group compatibility, efficient reaction system, small environmental pollution and the like; diaryl thioether is an important pharmaceutical and chemical synthesis intermediate and chiral ligand, and has very wide application in the fields of biological medicine, organic synthesis, chemistry and chemical engineering and the like, so that the method has relatively high use value and social and economic benefits.