Application of gallic acid in reversing drug resistance of streptococcus suis to antibiotics

Abstract

The invention discloses an application of gallic acid in reversing drug resistance of streptococcus suis to antibiotics. The inventors uses a computer-aided drug design technology to accurately predict the relationship between the gallic acid and CysM through a computer molecular simulation docking means, so that the inventors speculate that the gallic acid can inhibit the binding of the CysM to asubstrate when acting on the CysM, and blocks cysteine synthesis to affect the adaptation of the streptococcus suis to an oxidative stress environment to affect the drug resistance to tylosin; in-vitro tests of tylosin-resistant bacteria of the streptococcus suis are further induced, the test results prove that the gallic acid has a good effect of reversing the drug resistance of the streptococcus suis to the tylosin, and the gallic acid affects the drug resistance to the tylosin by occupying the CysM enzyme activity center; and the inventors find that the gallic acid has a good reverse effect on the drug resistance of the streptococcus suis to the tylosin, provides a novel direction for solving the problem of the drug resistance of the streptococcus suis, and lays a foundation for a further clinical application.

Description

technical field [0001] The invention relates to a new pharmacological application of gallic acid, in particular to the application of gallic acid in reversing the drug resistance of Streptococcus suis to antibiotics, and belongs to the field of new pharmacological applications of gallic acid. Background technique [0002] Streptococcus suis (Streptococcus suis) belongs to Coccus family, Streptococcus, is a spherical bacteria. Most are arranged in short chains or in pairs, do not form spores, can form capsules, and Gram staining is positive. It mainly causes symptoms such as meningitis, arthritis, endocarditis, cellulitis and septicemia, and even causes sick pig death (Han Qiang. Screening of anti-S. suis BF Chinese medicine and emodin to virulence gene and luxS The impact of [D]. Northeast Agricultural University, 2014.). Streptococcus suis has a wide distribution and has been outbreaked in many places in China. It is one of the important infectious diseases in China's pig...

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Problems solved by technology

Studies have also proved that gallic acid has antibacterial activity against many bacteria, such as Salmonella typhimurium and Staphylococcus

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