The invention discloses a
biological effect-guided self-
adaptive radiotherapy system. The
system comprises an information input module, a three-dimensional
dose distribution calculation module, a deformation field calculation module, a
cumulative dose distribution calculation module, a
biological effect feedback calculation module, a
treatment plan generation module and an information output module; the information input module isused for inputting required
data information,the three-dimensional
dose distribution calculation module is used for calculating three-dimensional
dose distribution completing fractionated
irradiation and calculating the
dose distribution of the current fractionated
irradiation, the deformation field calculation module is used for calculating a deformation field, the
cumulative dose distribution calculation module is used for calculating cumulativedose distribution completing fractionated
irradiation, the
biological effect feedback calculation module is used for constructing the
total dose model,calculatingtotal
dose distribution and calculating the biological effect feedback of each organ in a patient, the
treatment plan generation module is used for generating a current fractionated irradiation plan, and the information output module is used for outputting the current fractionated irradiationplan. Accordingly, the biological effect feedback is utilized for guiding the fractionated irradiationplan optimizing process, and on the condition that fractionated irradiation has irradiation errors, the influence of repair and multiplication of cells amongfractionated irradiation on the radiotherapy quality is comprehensively considered.