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Pharmaceutical composition for prevention of rectal carcinoma radioactive skin damage and application thereof

A radioactive skin and composition technology is applied in the field of pharmaceutical compositions for preventing rectal cancer radioactive skin damage and the field of preparation thereof, which can solve the problems of patients not being able to perform regular radiotherapy, microthrombosis and microcirculation disturbance, and blisters, and the like. The effect of treating acute radiation reaction of skin, facilitating wound epithelization and healing, and preventing the loss of skin island

Inactive Publication Date: 2015-10-28
江琴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that after the skin is exposed to radiation for a long time, the skin microvascular endothelium is damaged, resulting in extensive microthrombus formation and microcirculation disturbance in the microvessels. Skin redness, itching, hyperpigmentation, thickening and roughness, thick and black pores, wet peeling, blisters may appear in severe cases, followed by ulceration, erosion, pain, etc., and even the radiation therapy of patients is forced to be interrupted, resulting in Patients cannot receive regular radiotherapy, which affects the therapeutic effect (Barlund M, Forozan P, Kononen J, et a1.Detecting activation ribosomal protein S6 kinase by complementaryry.DNA and tissue microarray analysis[J].J Natl Cancer lnst,2000,92( 15): 1252.)

Method used

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  • Pharmaceutical composition for prevention of rectal carcinoma radioactive skin damage and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0016] Prescription: 1.6kg of white leaf, 1.5kg of Tribulus terrestris, 1.5kg of mandarin core, 1.6kg of yellow eggplant flower, 2.5kg of Eupatorium, 2.5kg of Atractylodes macrocephala, 0.9kg of amomum, 1.5kg of red eclipta.

[0017] Preparation method: Take the above-mentioned raw materials of Chinese medicinal materials in the prescribed amount, wash and remove impurities, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add up for the first time Purified water with 12 times the amount of medicinal materials, decoct for 3 hours, take the decoction, filter, add up the purified water with 10 times the amount of medicinal materials for the second time, decoct for 2 hours, take the two decoctions and combine, filter, and concentrate to 65°C A concentrated solution with a relative de...

Embodiment 2

[0018] Embodiment 2: the preparation of Chinese medicine gel

[0019] Prescription: Chinese medicine dry cream powder 10g, carbomer 940:10g, propylene glycol 200g, laurocaprone 10g, triethanolamine 10g, Tween-80:10g, add distilled water to 1000g.

[0020] Sprinkle carbomer in an appropriate amount of distilled water, fully swell, add glycerin and half the prescribed amount of propylene glycol, grind laurocapram to make it wet, add triethanolamine to grind into a transparent gel matrix, and heat to 70°C in a water bath. Take Chinese medicine dry paste powder (prepared according to the prescription process of Example 1), Tween-80 and the other half of the prescription amount of propylene glycol, mix and heat to dissolve, then add the medicinal solution to the gel matrix, stir slowly and quickly, add distilled water to 1000g, continue to stir evenly to obtain a golden yellow transparent gel. Without adding traditional Chinese medicine dry paste powder, the blank gel was prepared...

Embodiment 3

[0021] Example 3: Clinical Application Research of the Pharmaceutical Composition of Traditional Chinese Medicine for Preventing Rectal Cancer Radiation Skin Damage

[0022] 45 patients diagnosed with rectal cancer underwent radiotherapy, including 26 males and 19 females, aged 52 to 73 years, with an average age of 57.4±6.9 years. After selection, the patients were randomly divided into a test group of 22 cases and a control group of 23 cases. There was no significant difference in gender, age, and condition between the two groups, and they were comparable. The two groups of patients were treated with 3DRT radiotherapy. The radiotherapy equipment was Siemens medical linear accelerator, and the radiation types were 6MV-X ray and 9mev β-ray. The radiotherapy was performed continuously 5 times a week from 1st to 5th week. Each week was a cycle, 6 cycles of radiotherapy, prescription The dose was 50Gy / 15 fractions, and CT was rechecked every 2 weeks during radiotherapy to evaluat...

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Abstract

The invention discloses a pharmaceutical composition for prevention of rectal carcinoma radioactive skin damage and an application thereof; the pharmaceutical composition is prepared from an active component and auxiliary materials; the active component is prepared by water extraction and alcohol precipitation of the following traditional Chinese medicine raw materials in parts by weight: 13-20 parts of potentilla fulgens wall, 12-18 parts of tribulus terrestris, 12-18 parts of mandarin orange seed, 13-20 parts of abelmoschus crinitus wall, 21-30 parts of herba lycopi, 21-30 parts of white atractylodes rhizome, 6-12 parts of fructus amomi, and 10-20 parts of herba hyperici. The pharmaceutical composition not only can delay the generation of radioactive skin damage, ensure smooth performing of radiation therapy and improve tolerability of patient skins on the cumulative dose of radiation, but also can promote healing of radioactive skin damage wound surfaces.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for preventing rectal cancer radiation skin damage, a preparation method and application thereof. Background technique [0002] Radiation therapy is the main method of comprehensive treatment of rectal cancer. It kills and inhibits the proliferation of tumor cells and also damages normal tissues of the human body. Skin radiation injury is a common complication in patients undergoing radiotherapy. It is a kind of complication caused by radiation-irradiated skin microvascular lesions and subsequent skin nutritional disorders and inflammatory reactions. Studies have shown that after the skin is exposed to radiation for a long time, the skin microvascular endothelium is damaged, resulting in extensive microthrombus formation and microcirculation disturbance in the microvessels. Skin redness, itching, hyperpig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P17/02A61P35/00
Inventor 不公告发明人
Owner 江琴
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