37 results about "Chronic asthma" patented technology

A remedy and / or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and / or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2.

A remedy and / or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and / or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2.

The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.

The present invention relates to methods of asthma treatment and prevention using αvβ6 antagonists, such as αvβ6-binding antibodies. In particular, the invention relates to the discovery of a correlation between reduced expression of αvβ6 and the protection from the increase in airway sensitivity seen in chronic allergen-challenged mice. This protection is associated with protection from the usual allergen-induced increase in airway epithelial mast cells.

Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and / or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

The invention provides a method for constructing an IL-33 presentation VLP (Virus-Like Particle) vaccine used in active immunotherapy of chronic asthma. The method comprises the following steps: extracting IL-33 total RNA (Ribonucleic Acid) from a mouse; performing reverse transcription to obtain IL33 total cDNA (complementary deoxyribonucleic acid); performing PCR (Polymerase Chain Reaction) amplification on the obtained total cDNA with a designed specific primer to obtain a coded IL-33 mature segment gene; inserting the gene between 78-bit amino acid and 79-bit amino acid of a hepatitis B virus core antigen HBcAg to obtain a recombinant plasmid pHBcAg33; transferring the plasmid onto escherichia coli DH5alpha or a BL21 competent cell; inducing by using IPTG (isopropyl-beta-d-thiogalactoside) and purifying to obtain the IL-33 presentation VLP vaccine. A strong neutralizing antibody which is specific to own molecules and has a durable action can be induced by inoculating the vaccine repeatedly in order to regulate and control immune response, thereby fulfilling the aim of regulating and controlling the progress of asthma.

The present invention relates to the use of a composition comprising a fixed combination of a) formoterol, a pharmaceutically acceptable salt or solvate thereof or a solvate of such a salt; and b) beclometasone dipropionate; for the manufacture of a medicament for use in the prevention and / or treatment of an exacerbation of asthma, intermittent asthma and / or episodes in chronic asthma during the maintenance therapy of asthma with the same composition for symptomatic relief, when needed.

The invention discloses a bronchial asthma treating Chinese herbal medicine, which is granule, capsules and tablets prepared by thirteen pure Chinese herbal medicine materials; the thirteen pure Chinese herbal medicine materials comprises astragalus root, ephedra, poria cocos, oriental waterplantain rhizome, tuber of dwarf lilyturf, Chinese yam, coptis root, perilla leaf, white mulberry root-bark, liquorice root, red peony root, rhizoma zingiberis and purple gromwell root. The extracted active ingredient is reacted each other. The bronchial asthma treating Chinese herbal medicine has the advantages of blood activating and collaterals dredging, qi supplementing and yin nourishing, lung warming and cold dispelling, spleen-stomach strengthening, liver and kidney nourishing and cough relieving, which has significant therapeutic effect on acute and chronic bronchitis, asthma, chronic asthma bronchitis and the disease with the symptoms of asthma, cough and expectoration.

The present invention relates to the use of a composition comprising:(a) formoterol, a pharmaceutically acceptable salt of formoterol, a solvate of formoterol, or a solvate of a pharmaceutically acceptable salt of formeterol; and(b) beclometasone dipropionate;for the prevention and / or treatment of an exacerbation of asthma, intermittent asthma and / or episodes in chronic asthma during the maintenance therapy of asthma with the same composition for symptomatic relief, when needed.

A method for treating or prevent acute or chronic asthma is disclosed, comprising administering effect amounts of an FK506 derivative and a β2-agonist to a human being or an animal. A composition comprising an FK506 derivative and a β2-agonist as a combined preparation is also disclosed

The invention relates to a traditional Chinese medicine for remedying the chronic asthmatic bronchitis and belongs to the traditional Chinese medicine for remedying the chronic bronchitis. The main prescription is 12 grams of stiff silkworms, 5 grams of scorpions, 10 grams of earthworms, 10 grams of roasted ephedras, 10 grams of perilla fruits, 10 grams of caladiums, 12 grams of coltsfoots, 12 grams of Tatarian aster roots, 10 grams of bitter apricot seeds and 10 grams of schisandra fruits. The auxiliary prescriptions are that if the patient also has serious cold phlegm, 10 grams of dried gingers, 3 grams of asarums and 10 grams of pinellia rhizomes can be added; for the patient with hot phlegm in the lung channel, 10 grams of mulberry barks, 10 grams of tabasheers, 10 grams of snakegourd peels and 20 grams of heartleaf houttuynia herbs are added; the patient with deficiency of three organs of the lung, the spleen and the kidney, 15 grams of dangshen, 15 grams of milkvetch roots and 10 grams of geckoes are added. The compatibility of the traditional Chinese herbal medicines is simple; the medicines used in the medicine prescription are all natural herbal medicines which can be conveniently gotten and used; the manufacturing method is simple; the curative effect after being taken is good; the medicine price is cheap, and the medicine is especially fit for people who live at the remote small villages away from villages and towns to use. The treatment expense for the patient with the disease of the chronic asthmatic bronchitis is low, which solves the treatment problem which is caused by low family income, poor living and lack of local medical treatment condition.

The invention discloses a compound combination medicament for treating asthma and a preparation method thereof. The compound combination medicament comprises the following components in part by weight: 10 to 60 parts of blackberrykiky rhizome, 20 to 50 parts of prepared ephedra herb, 40 to 100 parts of snakegourd fruit, 15 to 60 parts of longstamen onion bulb (fried), 10 to 60 parts of stiff silkworm (fried), 20 to 60 parts of white paeony root (fried), 10 to 100 parts of pepperweed seed, 5 to 70 parts of prepared liquoric root, 15 to 120 parts of earthworm, 10 to 110 parts of common cnidium fruit, 10 to 150 parts of clam shell, 10 to 60 parts of bitter almond kernel, 5 to 160 parts of anisetree bark, 40 to 200 parts of kadsura pepper stem, 10 to 100 parts of peach seed and 10 to 60 parts of baical skullcap root. The compound combination medicament of the invention is used for treating chronic asthma, gurgling with sputum in throat, chest distress, breathing obstruction, shortness of breath, coughing, white phlegm asthma or phlegm-heat type asthma, and has the characteristics of good and thorough curative effect, short treatment course and no side effect and the like. The compound combination medicament can be prepared into mixtures, tablets, capsules, micropills and the like to facilitate carrying and administration.

The invention discloses a spraying agent for treating asthma and a preparation method thereof. The spraying agent contains angelica volatile oil serving as an effective part for relieving asthma, and pharmaceutically allowable auxiliaries, wherein a spraying agent emulsion is prepared through weighing, mixing and setting volume, emulsifying and the like; and 0.2 to 15ml of the angelica volatile oil is contained in each 100ml of the spraying agent emulsion. The angelica volatile oil is easily volatized, has small local irritation, and is more suitable for administration in a local spraying inhalation, so that the medicament can directly reach a pathological position and has quick acting and good curative effect; and less drug is absorbed and enters blood circulation, and the adverse reaction of the whole body is light, so that the spraying agent is more suitable for long-term preventive administration in intermission phase of asthma. The volatile oil has the treatment effect on pulmonary hypertension, pulmonary heart disease, arrhythmia and other complications caused by chronic asthma while overcoming adverse reactions of beta2 receptor agonists and xanthine medicaments.

The invention discloses a traditional Chinese medicinal composition for treating asthma. The traditional Chinese medicinal composition mainly comprises seaweed, stemona, kelp, viola yedoensis, angelica sinensis, the root of kudzu vine, pseudo-ginseng, scrophulariae, earthworm, musk, rhinoceros horn, platycodon grandiflorum, radix ophiopogonis, pigeon shit, pinellia ternate, tangerine peel, tuckahoe, white sandalwood, amomum cardamomum and gecko. Thousands of clinical experiments prove that the traditional Chinese medicinal composition and the preparation thereof disclosed by the invention have a treatment effect on bronchial asthma, allergic asthma and other types of acute or chronic asthma. The states of patients with asthma are abated at different degrees by taking the traditional Chinese medicinal composition disclosed by the invention, and the patients can be cured within 10 to 30 days.

Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).

The invention discloses a specific Chinese medicinal preparation for treating bronchial asthma. The specific Chinese medicinal preparation is a powder mixture prepared by mixing the following components in parts by dry weight: 1-2 parts of bletilla striata, 1-2 parts of bulbus fritilariae, 1-2 parts of ramulus mori, 1-2 parts of herba scutellariae barbatae and 1-2 parts of agrimony, preferably 1 part of agrimony, 1 part of bulbus fritilariae, 1 part of ramulus mori, 1 part of herba scutellariae barbatae and 1 part of agrimony, wherein the preparation is generally powder and can be a capsule. The preparation is greyish-white powder which takes bitter and cool. The usage and the dosage are as follows: the preparation is taken with warm crystal sugar water before meals thrice a day with 6 grams each time, raw and cold foods, sour and hot foods, fishes, and shrimps and all irritating foods can not be eaten during the day of preparation taking. The preparation follows the principle of 'winter disease being cured in summer'. A patient is suggested to take the preparation after the beginning of summer and before the beginning of autumn under a non-pathogeny condition so that a better healing effect is achieved. Under general conditions, a disease can be cured by taking the preparation for one period of treatment and does not relapse. As proved by practical clinical application to patients, the specific Chinese medicinal preparation has the effective rate of 100 percent on ordinary asthma, bronchial asthma and chronic asthma.

The present invention relates to use of a composition for symptomatic relief, when needed, comprising, in admixture(a) a first active ingredient which is formoterol, a pharmaceutically acceptable salt or solvate thereof or a solvate of such a salt; and(b) a second active ingredient which is budesonide;for the manufacture of a medicament for use in the prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma. The invention further relates to a method for prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma by administering, by inhalation, a composition comprising the first and second active ingredients as defined previously.

The invention discloses common yam rhizome powder for conditioning chronic asthma and a preparation method thereof. The common yam rhizome powder is prepared from common yam rhizome powder, pollen, lotus seed starch, sculellaria barbata, hairyvein agrimony, herba ephedra, radix scrophulariae, safflower, radix angelicae, burdock, young elm seeds, dried tangerine or orange peel, madder, semen cassiae torae, fructus aristolochiae, abrus cantoniensis hance, lalang grass rhizomes, flos paulowniae, cortex mori radicis and wild winter chrysanthemum flowers. All the traditional Chinese medicine is mixed in proportion, water is added, the mixture is decocted into liquid medicine, then the pollen and the lotus seed starch are added, the materials are stirred to be uniform, the mixture is subjected to vacuum concentration to form thick paste, the thick paste is subjected to decompression drying to be smashed into powder, the powder is combined with the common yam rhizome powder, and cookies or bread or steamed sponge cakes are prepared. The traditional Chinese medicine is combined with food, the food therapy effect of the food is exerted, and the treatment and conditioning effects of the traditional Chinese medicine are exerted; the common yam rhizome powder has a good conditioning effect on chronic pneumonia, has no toxic and side effect and is safe and effective, and the physique of a patient can be improved well.

The invention discloses chronic asthma prevention and treatment food and a preparation method thereof. The food is prepared from Amylum Puerariae, pollen, lotus seed powder, Herba Scutellariae Barbatae, Herba Agrimoniae Pilosae, Herba Ephedrae, Radix Adenophorae, Flos Carthami, Pheretima, Rhizoma Corydalis, Rhizoma Pinelliae, Radix Adenophorae, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Semen Cassiae, Semen Raphani, Herba Leucatis Molloissima, Radix Paeoniae Rubra, Arisaema Cum Bile, Fructus Viticis, Herba Patriniae and Herba Plantaginis. The preparation method includes: mixing the traditional Chinese medicines, adding water for decocting to obtain a decoction, adding Amylum Puerariae, pollen and lotus seed powder, well stirring, performing vacuum concentration to obtain thick paste, performing vacuum drying, grinding into powder, and combing with wheat flour or rice flour to make biscuits, bread or steamed sponge cake. By combination of the traditional Chinese medicines and the food, diet therapy functions of the food are achieved while treatment and regulation functions of the traditional Chinese medicines are realized. The chronic asthma prevention and treatment food has an excellent curative effect on chronic pneumonia and is free of toxic and side effects, safe, effective and capable of remarkably improving immunity of patients.

A slow-releasing theine-chitosan microball for treating chronic bronchitis and chronic asthma is prepared through dispersing theine in chitosan solution, adding the oil-phase substance containing surfactant, stirring, adding the aqueous solution of ammonium sulfate, stirring, depositing, separating, washing and vacuum drying.

The invention discloses an external traditional Chinese medicine bag for treating asthma, which is characterized by comprising the following components in weight ratio: 12 parts of white mustard seeds, 10 parts of combined spicebush roots, 10 parts of dried ginger, 10 parts of platycodon roots and 6 parts of fineleaf schizonepeta herbs. The external traditional Chinese medicine bag is prepared by mutually compounding phlegm reducing and vital energy flow regulating components, has the efficacy of warming the lungs, reducing phlegm, dispelling wind, dissipating coldness, benefiting the pharynx, eliminating pus and the like and can treat the diseases of chronic asthma, cough variant asthma, chronic tracheitis or chronic pharyngitis and the like. The invention has the advantages of low cost, convenient use, high safety, small side effect, quick effect taking, obvious effect and the like.

Provided is a medicine bag for treating bronchitis and emphysema. The medicine bag for treating the bronchitis and the emphysema is prepared from common lantana leaves, Chinese fevervine herbs, fennel, ephedra herbs, menthol, roots of sinuate tickclover, stems and roots of flatstem rockvine, Chinese leucas, Indian mockstrawberrg herbs, rhizoma paridis chinensis, wideleaf osbeckia roots, herbs of dwarf denseflower elsholtzia, lumbricus, human placenta, inula flowers, periostracum cicada, chaste tree fruits, negundo chaste tree fruits, fructus meliae azedarach and fructus toosendan. A preparation method comprises the steps that all the medicinal materials are smashed and mixed together, the materials are packed in a packaging bag made of filter paper according to the quantity and sealed to obtain a finished product metheph medicine bag. The medicine bag for treating the bronchitis and the emphysema is wide in effect, and the effects of diffusing the lung, depressing Qi, eliminating phlegm, relieving the asthma, relieving a cough, removing the phlegm, resisting bacteria, sterilizing, killing tuberculosis worms, diminishing inflammation, benefiting the lung and the like on the bronchitis and the emphysema are achieved; obvious treatment effects on acute bronchitis, pulmonary emphysema, cough and asthma relieving, chronic cough, chronic asthma, asthma and the like are achieved, and the cure rate reaches over 98 percent.

The invention provides a dietotherapy formula for treating chronic asthma. The dietotherapy formula comprises 500g of pumpkins, 20 red dates and a pinch of brown sugar. The dietotherapy formula is suitable for chronic asthma patients in different age stages and utilizes a medical treatment principle of supplementing the center and boosting qi, tonifying qi and relieving asthma, and improving patient immunity. Through use of the dietotherapy formula for treatment for some time, patient chronic asthma can be thoroughly cured. The dietotherapy formula can be used simply and has no toxic or side effect.

All-herb pills for curing asthma are prepared from common lantana leaves, roots or leaves of pilose triumfetta, foeniculi fructus, herba ephedrae, mentholum, sinuate tickclover roots, tetrastigma planicaule, Chinese leucas, Indian mockstrawberrg herbs, rhizoma paridis chinensis, wideleaf osbeckia roots, herbs of dwarf denseflower elsholtzia, lumbricus, human placenta, inula flowers, periostracum cicada, chaste tree fruits, negundo chaste tree fruits, China berry fruits, Szechwan China berry fruits, rock sugar and molasses. The preparation process comprises the steps that all the medicinal materials are smashed and mixed together, an adequate amount of honey is put and stirred, and the pills are prepared; all the combined medicinal materials have a good effect on curing the asthma. The all-herb pills for curing the asthma is wide in function, and the effects of diffusing the lung, depressing Qi, eliminating phlegm, relieving the asthma, relieving a cough, removing the phlegm, resisting bacteria, sterilizing, killing tuberculosis worms, diminishing inflammation, benefiting the lung and the like are achieved; obvious curing effects on acute bronchitis, cough and asthma relieving, chronic cough, chronic asthma, pulmonary emphysema, asthma and the like are achieved, and the cure rate reaches above 98 percent.

The invention discloses a chronic asthma daily monitoring APP design method based on user experience. The method comprises the steps that first, the principle and the design method of user experienceare discussed by reading documentation; second, research and practice are performed on a series of problems, such as user demand analysis and mining and conversion of user demands into actual development function points; third, research is performed on scheme design, and whether the design principle of the user experience and the usability of products are fully considered in the scheme design is analyzed; and fourth, the user experience of the products is improved through dynamic effect design. According to the chronic asthma daily monitoring APP design method based on the user experience, thedesign process is around specific characteristics of an asthma patient group, so that usability is high; a vivid dynamic effect is used to change the boredom of text question answering, and the method is vivid and interesting; and an asthma user can record the state of illness anywhere and anytime, and medical record data is easy to manage in long-period asthma treatment.