62 results about "Cell splitting" patented technology

A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.

A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.

This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and / or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.

The invention relates to a solar cell module and a production method thereof. The solar cell module comprises a plurality battery cutting blades, which are serially connected together in an overlapped manner; and connecting members, which are used to serially connect the adjacent battery cutting blades. The battery cutting blades are cut by the solar cell pieces, and comprise front surface electrodes and back surface electrodes. Each of the connecting members comprises a first surface connected with the corresponding front surface electrode and a second surface connected with the corresponding back surface electrode, and the first surface is provided with first connection areas and first non-connection areas, which are arranged alternately, and the second surface is provided with second connection areas and second non-connection areas, which are arranged alternately, and in addition, the projections of the second connection areas on the first surface are covered by the projections of the first non-connection areas on the first surface. The front surface electrodes are connected with the first connection areas, and the back surface electrodes are connected with the second connection areas. By adopting the solar cell module, the elasticity of the solar cell module can be improved, and the gate-breaking and the cell-splitting are not easy to occur. The invention also provides the production method of the solar cell module.