Method and apparatus for interference mitigation in wireless local area networks (such as WLANs). In one embodiment, a centralized interference measurement and mitigation method is disclosed. The method may involve spectral sensing, beamforming, MIMO, power control, MAC scheduling using a cross-layer approach, and / or broadcast channel precoding, employed towards performance enhancement of WLAN networks in presence of interference. In one variant, different actions at interference mitigation are selected based on the source of the interference (e.g., inter-network or intra-network).