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71 results about "Behavioural disorders" patented technology

Method for treating eating disorders

The present invention is a method for the treatment of eating disorders by nerve tissue stimulation and infusion techniques to one or more areas of the brain affecting hunger and satiety; palatability and aversion; hedonism; reward / addiction behavior; mood; anxiety; depression, taste and smell. The invention also comprises methods for the treatment of disorders of these individual behaviors and in particular, disorders of taste and / or smell.
Owner:LOZANO ANDRES M

Novel Therapeutic Compounds

The present invention describes a series of therapeutically active compounds of formula I,X—Y—Z  (I)that are useful for treating a disorder in a mammal. In the formula I, X and Z, which may be same or different, are independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclic group or substituted or unsubstituted heterocyclylalkyl; and Y is a linker selected from —O—, —S—, —NH—, —(CH2)n—, —CO—, —CONRa—, —NRaCO—, —NRaCOO—, —COO—, —CONRaCO—, —CONRaCOO— and —COOCOO—. The compounds are useful to treat neurodegenerative disorders, depression, Alzheimer's disease, cognitive disorders, motor disorders, Parkinson's disease, drug addiction, behavioral disorders, inflammatory disorders, stomach disorders, cancers, acute pain, chronic pain and recurrent pain.
Owner:GRUNENTHAL GMBH

Use of stellate ganglion block for the treatment of psychiatric and behavioral disorders

The present invention is directed to a method for the treatment of a patient suffering from psychiatric and behavioral disorders, including post partum depression, post traumatic stress disorder, compulsive smoking, attention deficit hyperactivity disorder, gambling addiction, comprising the step of administering a stellate ganglion block to the patient to alleviate the symptoms. The stellate ganglion block may be followed by a sympathectomy to provide permanent relief.
Owner:LIPOV EUGENE

Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

The present disclosure relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
Owner:CHONG KUN DANG PHARMA CORP

Rapid eye movement period sleep behavior disorder classification method based on sleep electroencephalogram

ActiveCN111493822ADiagnostic recording/measuringSensorsPattern recognitionRapid eye movement sleep
The invention discloses a rapid eye movement period sleep behavior disorder classification method based on sleep electroencephalogram. The method comprises the following steps: preprocessing an acquired sleep electroencephalogram signal of a patient, acquiring an electroencephalogram signal of an electroencephalogram interval in a sleep R period, cutting according to a preset signal length to acquire a plurality of sub-signal segments, layering an original electroencephalogram signal of each sub-signal segment, and enabling a frequency domain component after wavelet transform to approximatelycorrespond to different wave bands of original electroencephalogram according to the frequency of the electroencephalogram; carrying out empirical mode decomposition (EMD) to obtain a multilayer intrinsic mode function (IMF); performing feature extraction on the electroencephalogram signals of different wave bands and the multilayer intrinsic mode function, and performing dimensionality reductionon the feature set PCA to obtain a low-dimensional feature set; and carrying out classification and identification by using the feature set after dimension reduction, and classifying patients suffering from Parkinson's disease accompanied by rapid eye movement sleep disorder, Parkinson's disease not accompanied by rapid eye movement sleep disorder and idiopathic rapid eye movement period sleep behavior disorder. Complex PSG detection is simplified into electroencephalogram detection, a whole night does not need to be consumed, the number of times of measurement is reduced, an accurate recognition result is obtained, and then a very good auxiliary effect can be achieved on treatment of the illness state of a patient.
Owner:济南国科医工科技发展有限公司

Composition for the treatment of neurobehavioral disorders

The invention relates to a composition for use in the treatment of neurobehavioral disorders, a Cannabis plant extract comprising Cannabinol preferably with other constituents of this plant for such use and a method for the extraction of plants. The plants or plant parts may for instance be derived from Cannabis sativa and / or Cannabis indica and / or Cannabis ruderalis and / or citrus fruits, and mixtures thereof. The plant extracts derived showed particularly beneficial effects against sleeping disorders, in particular insomnia, and anxiety disorders including ADHD.
Owner:CANNABIS SCI INC

Small molecule immunomodulators for alzheimer's disease

Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, ALS, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for evaluation in animal models of neurodegenerative diseases.
Owner:HUMAN BIOMOLECULAR RES INST

Medicament composition for treating cardiac and cerebral vascular disease

The invention belongs to the technical field of medicine and discloses a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition is prepared by ginsenoside and carithamine as main ingredients and can be prepared into pharmaceutically or clinically acceptable dosage forms. The pharmaceutical composition has functions of expanding blood vessels of brain, reducing cerebral vascular resistance, increasing cerebral blood flow, obviously minimizing infarct area of brain tissues, obviously lightening behavior disorders caused by brain tissue necrosis, and the like, and can be used for preparing medicaments for treating diseases such as cerebral circulation insufficiency, cerebral thrombosis, cerebral embolism, brain blood vessels spasm, brain insufficiency, senile dementia, Parkinsonism, cerebral apoplexy, hypertension, hyperlipemia, arteriosclerosis, coronary heart disease, angina pectoris, miocardial infarction, etc.
Owner:GUIZHOU XINBANG PHARMACEUTICAL CO LTD

Early warning method and device for cognitive and behavioral disorders, equipment and storage medium

The invention relates to the field of medical treatment, and discloses a cognitive and behavioral disorder early warning method, device and equipment and a storage medium, and the method comprises the steps: obtaining the basic information of a detected object, inputting the basic information into a graph neural network, and obtaining a first prediction probability H1; receiving a biological signal uploaded by a monitoring bracelet of a measured object, and inputting the biological signal to the XGboost model to obtain a second prediction probability H2; receiving daily monitoring data uploaded by the monitoring bracelet, and inputting the daily monitoring data to the RNN model to obtain a third prediction probability H3; performing weighted calculation on the H1, the H2 and the H3 based on a preset weighting algorithm to obtain a disease probability H4 of the detected object; and if the H4 is higher than the preset probability threshold, generating an early warning signal, and sending the early warning signal to a preset port. Aiming at the technical problem that the disease and disease development of a patient cannot be monitored in real time at present, the method aims at finding the disease in advance, monitoring the specific physiological condition of the patient in real time in daily life, improving the diagnosis efficiency and realizing uninterrupted monitoring measures.
Owner:PING AN TECH (SHENZHEN) CO LTD

Methods for identifying compounds as antioxidants

The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and / or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.
Owner:EMORY UNIVERSITY +1

Probiotic composition and preparation for treating rapid eye movement sleep behavior disorder in patients with Parkinson disease and applications of probiotic composition and preparation

ActiveCN111297915ANo side effectsLow priceNervous disorderUnknown materialsRapid eye movement sleep behaviour disorderPatients symptoms
The invention discloses a probiotic composition for treating rapid eye movement sleep behavior disorder (RBD) in patients with Parkinson disease (PD). The composition is prepared from bacillus licheniformis, bifidobacterium longum, lactobacillus acidophilus, enterococcus faecalis and pharmaceutically acceptable auxiliary materials, wherein the number of live bacteria of the bacillus licheniformisis not less than 10.0x10<8> CFU/g; the number of live bacteria of the bifidobacterium longum is not less than 4.0x10<8> CFU/g; the number of live bacteria of the lactobacillus acidophilus is not lessthan 1.0x10<8> CFU/g; and the number of live bacteria of the enterococcus faecalis is not less than 0.5x10<8> CFU/g. In the probiotic composition, the components have a synergistic effect, the RBD symptom in the PD patients can be effectively treated and improved, and the treatment effect is good in continuity and excellent in stability; the composition can effectively improve the motor symptom ofthe PD patients while having a treatment effect on the RBD symptom of the PD patients, and solves the problem that current drugs cannot treat the motor symptom and non-motor symptoms of the PD patients at the same time; and the composition can effectively reduce the dosage of levodopa in the PD patients and prevent the patients from generating resistance to levodopa prematurely, and has a betterprotection effect on the patients.
Owner:BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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