49 results about "Bacterial Disorder" patented technology

Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.

Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.

The invention relates to a florfenicol solid dispersoid and a preparation method thereof. The solid dispersoid comprises the components of: florfenicol and a carrier. The carrier combination is reasonable, a rapid supercritical gas expansion technology and a super micro powder technology are combined to be used, an organic solvent is not required, the solubility of a product in water is greatly improved, the bioavailability is effectively improved, and bacterial diseases (which are caused by sensitive bacteria) of beasts and birds can be effectively cured. Besides, the preparation process is simple and easy to operate, the product is harmless and environment-friendly, the curative effect is excellent, and the like.

Disclosed is an aquaculture creature disease controlling compound vaccine which mainly comprises vibrio alginolyticus, bibrio parahemolyticus, vibrio alginolyticus, Aeromonas hydrophila, Aeromonas sobria, Pseudomonas aeruginosa, and Vibrio alginolyticus. The invention also discloses the preparing process for the composite bacterial vaccine.

The invention discloses a method for preparing a chelerythrine medicament and application thereof in prevention and treatment of bacterial diseases of aquatic animals. The medicament consists of chelerythrine and starch serving as an auxiliary material. The method for preparing the prevention and treatment agent comprises the following steps of: weighing chelerythrine extract (the purity is 80 percent) and starch serving as the auxiliary material, adding the chelerythrine extract and the starch into a mixer, and mixing the chelerythrine extract and the starch uniformly to obtain a preparation containing 5 to 20 percent chelerythrine. When the bacterial disease prevention and treatment agent is added into feed for feeding, the dosage is 200 to 250 mg / kg (according to the quantity of the chelerythrine for each kilogram of weight); the prevention and treatment agent added in the feed has low toxicity, does not affect the quality of aquatic products, has no residue or pollution, is not easy to generate medicament resistance, does not affect the feed and growth of the aquatic animals, has low dosage, and is widely applied in prevention and treatment of bacterial hemorrhage diseases of mandarin fish, weever, carp, grass carp, eel, porgy, flounder and the like.

The invention relates to the technical field of livestock medication and specifically relates to a compound formula of gallic acid and rhein, a preparation method and an application thereof. The compound formula is capable of preventing and treating viral and bacterial diseases of livestock. The compound formula of gallic acid and rhein comprises the following components in parts by weight: 75-80parts of gallic acid and 20-25 parts of rhein. An in vivo test proves that the compound formula of gallic acid and rhein has the function of preventing and controlling bird flu H9N2 subtype, bursal disease virus, chicken escherichia coli, and the like, and is capable of effectively killing pathogenic bacteria of animals, such as bovine escherichia coli, swine escherichia coli and swine bacillus cereus.

The invention discloses a multi-effect active iodine disinfectant, which is prepared from the following substances in percentages by weight: 1 to 12 percent of iodine, 0.1 to 2 percent of potassium iodate, 0.5 to 3 percent of potassium iodide, 20 to 50 percent of surfactant, 0.1 to 5 percent of organic acid, 5 to 30 percent of organic solvent, 0.5 to 5 percent of inorganic salt and the balance of purified water. The invention also provides a preparation method and application of the multi-effect active iodine disinfectant. The multi-effect active iodine disinfectant is mainly used for the disinfection of breeding houses, appliances, body surfaces and drinking water of livestock and poultry, the disinfection of a water body for aquaculture, the disinfection of an appliance for the aquaculture and the field of the prevention and the control on animal bacterial diseases in the aquaculture.

The invention discloses a compound microcapsule for treating bacterial disease of livestock and poultry and a preparation method thereof. The compound microcapsule mainly comprises the following components in part by weight: 10 to 20 parts of origano oil, 15 to 30 parts of levofloxacin and 30 to 60 parts of capsule material. The Chinese medicinal preparation origano oil is combined with the western medicine levofloxacin to prepare the compound microcapsule. The western medicine levofloxacin fast sterilizes, and the Chinese medicinal preparation origano oil assists sterilizing, and the origano oil and the levofloxacin can regulate body functions of the livestock and poultry and improves immunity at the same time. The compound microcapsule has the advantages of synergistic effects because of the combination of the Chinese medicinal preparation and the western medicine, obvious sterilizing effect, no toxic or side effect of the medicaments, and capability of treating both principal and secondary aspects of diseases. In addition, the compound microcapsule solves the problem of poor stability of the origano oil used as essential oil, and makes the origano oil easily and stably combined with the western medicine levofloxacin.

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R1 and R9 is independently selected from: —H; C1-4 alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C4-1 alkyl; each of R7NA and R7NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

The invention provides a Cyrtomium fortunei and ebony traditional Chinese medicine composite. The composite is a mixture of the alcohol extract of Cyrtomium fortunei, the alcohol extract of ebony and cinnamic acid in a certain ratio or an extract prepared by carrying out alcohol extraction after ebony and Cyrtomium fortunei are mixed in a certain ratio, and the composite also contains conventional pharmaceutic adjuvants and excipients. The invention also provides a preparation method and application of the Cyrtomium fortunei and ebony traditional Chinese medicine composite. The Cyrtomium fortunei and ebony traditional Chinese medicine composite has good prevention and treatment effects on poultry bacterial diseases and virus diseases, especially poultry diseases caused by escherichia coli and chlamydia and poultry diseases caused by bursal disease viruses and avian influenza. Moreover, the Cyrtomium fortunei and ebony traditional Chinese medicine composite has available raw material, lower cost and convenient and easy preparation process.

The invention provides a hempleaf groundsel herb phenolic acid ingredient as well as a preparation method and application thereof. The hempleaf groundsel herb phenolic acid ingredient is the ethanol washing part obtained by separating a hempleaf groundsel herb aqueous extract through D101 macroporous resin, and the total phenolic acid purity is 70.42-76.43%. The antioxidant, anti-inflammation andanti-bacterial capabilities of the hempleaf groundsel herb phenolic acid ingredient are evaluated through a chemical and biological method, and the result shows that the hempleaf groundsel herb phenolic acid ingredient has the outstanding treatment effect in a oxidative damage model of human bronchial epithelial cells. The hempleaf groundsel herb phenolic acid ingredient can be applied to treatment or auxiliary treatment of diversified human or animal bacteriosis, lung infection, cancers and various kinds of diseases such as systemic inflammation and oxidative stress caused by different reasons, and has the wide application prospects.

The invention discloses a compound Chinese herbal medicine for inhibiting and killing aeromonas hydrophila as well as a preparation method and application of the compound Chinese herbal medicine. The compound Chinese herbal medicine consists of gallnut, sanguisorba officinalis root and rheum officinale, wherein the weight ratio of the gallnut, to the sanguisorba officinalis root to the rheum officinale is at 5 to 2 to 1. Meanwhile, the invention discloses a preparation method and application of the compound Chinese herbal medicine for inhibiting and killing aeromonas hydrophila. The compound Chinese herbal medicine disclosed by the invention achieves the reasonable development and utilization of compound Chinese herbal medicine resources; in culture of aquatic animals, the compound Chinese herbal medicine has a great significance in guaranteeing animal nutrition, promoting growth of the animals and improving the disease preventing and disease resisting capacities of the animals, and meanwhile the compound Chinese herbal medicine is also in line with the requirements of aquaculture in sustainable development; in order to reduce loss of the aquaculture industry caused by diseases, a medicine, which is relatively strong in effect and low in toxic and side effects, becomes particularly important in the prevention and control of the diseases; and by taking the aeromonas hydrophila as a research object, the compound Chinese herbal medicine, which is relatively good in antibacterial effect, is screened out, so that the invention provides reference for prevention and control practice of diseases in aquatic animals and fish bacterial diseases caused by the aeromonas hydrophila.

The invention relates to a florfenicol solid dispersoid and a preparation method thereof. The solid dispersoid comprises the components of: florfenicol and a carrier. The carrier combination is reasonable, a rapid supercritical gas expansion technology and a super micro powder technology are combined to be used, an organic solvent is not required, the solubility of a product in water is greatly improved, the bioavailability is effectively improved, and bacterial diseases (which are caused by sensitive bacteria) of beasts and birds can be effectively cured. Besides, the preparation process is simple and easy to operate, the product is harmless and environment-friendly, the curative effect is excellent, and the like.

The invention relates to the field of preventing and treating aquatic farming animal diseases, in particular to an antibiotic and anti-inflammatory medicament for preventing and treating bacteria diseases of aquatic farming animals. The medicament comprises the following compositions in weight portion: 10 to 20 portions of mountain rhubarb, 15 to 25 portions of root of large-flowered skullcap, 1 to 5 portions of glucan, 5 to 15 portions of garlic, 3 to 8 portions of florfenicol and 50 to 90 portions of carrier, wherein the traditional Chinese medicine compositions are crushed into superfine powder, mixed with the glucan, the florfenicol and the carrier according to the mixing ratio and evenly stirred to prepare the medicament. The medicament has the good functions of treating bacteria diseases of aquatic farming animals, and addressing both the symptoms and root causes, thereby lowering the recurrence rate and the death rate of aquatic farming animal diseases; moreover, no medicament residue is existed.

The invention relates to an antibacterial and anti-virus injection and belongs to the field of biomedicines. A main component of the medicine is inactivated clostridium butyricum; the injection is prepared by inactivating live clostridium butyricum; the inactivated clostridium butyricum has antibacterial and anti-virus effects after being injected and can be used for prevention, treatment or adjuvant treatment of various bacterium diseases and virus diseases of human or animals, so that the injection has a wide application prospect.

Applicants have examined two Clostridium species, Clostridium difficile and Clostridium perfringens, and found that clays can adsorb the toxin produced by both and that a clay blended product can decrease the effects of a prominent in chickens and known as Necrotic Enteritis, that is caused by C. perfringens. Recently a clay or a clay blend that may be a combination of clay, yeast, and a form of a functional amino acid, was examined and found to help decrease the effects of acute hepatopancreatic necrosis disease (AHPND), which is also known as Early Mortality Syndrome (EMS) in shrimp when a challenge model that included Vibrio parahaemolyticus was used.

The invention belongs to the technical field of poultry breeding feed, and particularly relates to a feed formula for poultry broiler breeding, which comprises feed components and Chinese herbal medicine auxiliary material components, the feed component consists of the following raw materials in parts by weight: 38-55 parts of corn, 20-22 parts of soybean meal, 6-8 parts of peanut cakes, 3-5 parts of bran, 3-5 parts of fish meal, 9-12 parts of limestone flour, 1-3 parts of calcium hydrogen phosphate, 0.2-0.5 part of zinc sulfate, 0.1-0.5 part of methionine, 0.1-0.5 part of lysine, 0.1-0.5 part of vitamins for chickens, 0.5-2 parts of vegetable oil and 2-3 parts of an additive. According to the invention, mineral elements necessary for livestock and poultry are supplemented, so that the broiler chicken achieves relatively good nutrient balance, the weight gain of the broiler chicken is increased, and the chicken flavor is improved; the Chinese herbal medicine auxiliary material components are used for replacing antibiotics, so that chicken bacterial diseases, chicken paratyphoid fever and other chicken diseases can be prevented and treated, poultry broilers have excellent disease resistance and high survival rate, and meanwhile, the weight gain of the broilers is further improved.

Use of the compound Pulsatilla Saponin B4 represented by formula (I), or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating viral and / or bacterial diseases, and a medicament comprising the compound Pulsatilla Saponin B4 represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the disease is dairy cow mastitis.

The invention belongs to the technical field of immunoenhancers, and particularly relates to an immunoenhancer and application thereof and fish feed for enhancing immunity. The immunoenhancer comprises the following components in parts by mass: 2,000-6,000 parts of clostridium butyricum, 15-45 parts of vitamin C and 5-30 parts of vitamin E, wherein the living bacterial count of the clostridium butyricum is larger than or equal to 10*10<8> CFU / mL. The immunoenhancer not only solves the problem of frequent occurrence of bacterial diseases in pelteobagrus fulvidraco pond culture, but also does not produce drug resistance, guarantees eating safety of cultured products and achieves significant economic, social and ecological benefits.

This invention relates to Glycine-rich protein (Glyrichin), as well as its coding gene and application, especially relates to the application for antibacterial purpose. The Glyrichin of the present invention are at least one selected from the following protein families: proteins having amino acid residues in Sequence 1, 3-14 in the Sequence List or protein with antibacterial activities having 1 to 20 amino acid residues of sequence 1, 3-14 being deleted, inserted and / or substituted and with 1 to 20 amino acid residue sequences being added to the carboxyl terminal or amino terminal of Sequence 1 and 3-14 of the Sequence List correspondingly. The Glyrichin of the present invention and the coding gene can be applied to antibacterial purpose, such as the preparation of drugs for prevention and / or treatment of human or livestock infectious bacterial diseases; for the preparation of products for prevention and / or treatment of potentially infectious bacterial diseases of different kinds of creatures; for the production of transgenic creatures which can defend against diseases and pests; for the preparation of the derivatives, antagonists as well as its ligands and antibodies of Glyrichin.

The subject matter of the invention is a diagnostic sensor that can be formulated into a diagnostic chewing gum that detects relevant concentrations of influenza viruses in the oral cavity. The technical application is the initial diagnosis by those affected themselves, e.g. sore throats manifesting in them. By the detection of the influenza viruses a selective therapy of the infection is possible and employment of antibiotics that only are effective with bacterial diseases can be reduced.

The invention discloses an antibody ELISA detection method based on salmonella pullorum X protein coating, and relates to the field of poultry bacterial disease detection. An SPF chicken-derived high-affinity polyclonal antibody of salmonella pullorum is prepared and purified, and an electron carrier in an electron transfer chain and a dominant antigen X protein with oxidordeuctase activity are screened and identified by adopting an immunocoprecipitation technology; the exocrine dominant antigen X protein is constructed, expressed and purified by a specific mild method; and an indirect ELISA method for detecting the salmonella pullorum antibody is established. The salmonella pullorum positive antibody can be effectively detected, and the specificity and sensitivity of an existing detection technology are improved; and a powerful tool is provided for purifying salmonella pullorum of enterprises.

The invention provides the application of total glycosides of cistanche deserticola and echinacoside in the preparation of medicines for preventing and treating alcoholic liver injury accompanied by intestinal injury and regulating intestinal flora. The results of pharmacological experiments showed that in the mouse model of alcoholic liver injury, total glycosides of cistanche and echinacoside could reduce the damage of liver tissue morphology in mice, reduce the lipid deposition in the liver of mice, and reduce the alanine aminotransferase (ALT) in mouse liver. ) and aspartate aminotransferase (AST) content, reduce the oxidative damage of mouse liver, reduce the damage of harmful substances such as endotoxin to the liver, and at the same time, it can also reduce the damage of mouse small intestine tissue morphology, improve the integrity of intestinal wall villi, and regulate intestinal The flora is disturbed. It can be seen that the present invention has the prospect of being developed into a drug capable of simultaneously protecting alcoholic liver injury and alcoholic intestinal injury, and has important clinical significance and commercial value.

The invention relates to the use of a nasal spray made of cistus extracts for preventing and / or treating viral and / or bacterial oropharyngeal diseases.

The invention discloses a preparation method and application of a rabbit anti-grouper serum immunoglobulin HRP-labeled antibody, and belongs to the technical field of antibody preparation. The rabbit anti-grouper serum immunoglobulin HRP-labeled antibody is an enzyme antibody conjugate comprising HRP and a rabbit anti-grouper serum immunoglobulin antibody, the rabbit anti-grouper serum immunoglobulin HRP-labeled antibody can be specifically bound with grouper serum immunoglobulin for color development of a HRP substrate. The HRP-labeled antibody prepared by the method has high purity, high enzyme activity, suitable conjugate labeling rate, great dilution degree for performing ELISA tests, and high sensitivity, and can be used for detecting viral diseases, parasitic diseases and bacterial diseases of grouper.