The invention provides an air purification device which comprises a box body; and an air flue, a dust box, a high-pressure centrifugal blower, a high-pressure nozzle, and a motor are disposed in the box body. An air inlet is disposed at one end of the air flue, and an air outlet is disposed at the other end. An air-in fan is disposed at the air inlet at one end of the air flue, and an air-out fan is disposed at the air outlet at the other end. The air-in fan and the air-out fan are connected with the motor, and the air volume is 200 m3 / h. The high-pressure centrifugal blower and the high-pressure nozzle are connected with the motor. An HEPA filter screen, a static filter screen, a protein purifying unit and an active carbon filter screen are disposed in the air flue. The device of the invention is advanced in technical principle, strong in purification effect, and strong in practicality; the fiber filter screen, the static filter screen, the protein purifying unit and the active carbon filter screen are disposed in the air flue; with respect to substances of carbon monoxide, formaldehyde, benzene series, ammonia, TVOC, and the like, particles with a size of less than 0.3 microns can be filtered; the device is suitable for various places with requirements for air environment quality, such as homes, offices, production workshops, and the like.