The invention discloses a neuro-intervention head-neck fixing device. A head fixing plate can be movably installed on a supporting plate, a left splint is movably installed at the upper portion of the left side of the head fixing plate, a right splint is movably installed at the upper portion of the right side of the head fixing plate, a first tightening device and a second tightening device are both installed at the left side of the left splint in a front-back spaced mode, both the first tightening device and the second tightening device comprise shells, guide rods, slide rods, ratchet bars, and ratchets, a lifting device controls the slide rods to move up and down, the slide rods are slidably connected with slide blocks, the slide blocks are rotatably connected with connecting rods, the lower portions of manipulating rods are rotatably connected with the connecting rods, the ratchet bars are in slidably connected with the guide rods, the rackets are arranged at the lower portions of the slide blocks and are matched with the racket bars, the lower portions of the racket bars are fixedly connected with winch racks, the lower portions of the winch racks are meshed with winch gears, and shafts of the winch gears are provided with winches. The neuro-intervention head-neck fixing device is high in safety and reliability, the risk of occurrence of head dislocation of a patient in a neuro-interventio operation is drastically lowered, which is conducive to improvement of the curative effect of the operation.