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Application of sodium hypochlorite in the preparation of single-layer double-sided polypropylene/polydopamine patch

A technology of dopamine patch and sodium hypochlorite is applied in the field of medical materials and their preparation, which can solve problems such as easy displacement, and achieve the effects of reducing organ adhesion, good hydrophilicity and biocompatibility, and good tensile strength.

Active Publication Date: 2020-08-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both sides of the obtained composite patch are coated with polydopamine, that is, both sides of the obtained composite patch have anti-adhesion properties, and there is a risk of easy displacement, and there are still certain problems in clinical practice.

Method used

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  • Application of sodium hypochlorite in the preparation of single-layer double-sided polypropylene/polydopamine patch
  • Application of sodium hypochlorite in the preparation of single-layer double-sided polypropylene/polydopamine patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A polypropylene / polydopamine patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is a polypropylene mesh surface coated on the polypropylene mesh surface. Dopamine membrane, its preparation process is as follows:

[0033]Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0034] Step S2: adding sodium chloride into distilled water, continuously adding until it is configured as a saturated saline solution, and then, according to the volume of the saturated saline solution, a...

Embodiment 2

[0037] A polypropylene / polydopamine patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is a polypropylene mesh surface coated on the polypropylene mesh surface. Dopamine membrane, its preparation process is as follows:

[0038] Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0039] Step S2: adding sodium chloride into distilled water, and continuously adding until it is configured into a saturated saline solution, and then, according to the volume of the saturated saline solu...

Embodiment 3

[0043] A polypropylene / polydopamine patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is a polypropylene mesh surface coated on the polypropylene mesh surface. Dopamine membrane, its preparation process is as follows:

[0044] Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0045] Step S2: adding sodium chloride into distilled water, and continuously adding until it is configured as a saturated saline solution, and then, according to the volume of the saturated saline soluti...

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Abstract

The invention discloses application of sodium hypochlorite in preparing a single-layer double-sided polypropylene / polydopamine patch. According to the application disclosed by the invention, by usingthe principles that sodium hypochlorite can quickly peel a polydopamine film from polypropylene and the polypropylene patch density is smaller than that of a saturated saline solution, a single-layerpatch is divided into two sides on nanoscale, one side is a polypropylene / polydopamine film face which can effectively prevent the patch from being attached to organs in the enterocoelia, and the other side is a polypropylene face which is exposed after the polydopamine nanofilm is peeled; the polypropylene face is internally in contact with peritoneum to improve abdominal wall tension, so that displacement risk is reduced, the structure of the patch is more reasonable, and requirements in the peritoneum and the enterocoelia are met simultaneously. Meanwhile, the preparation method is not related to stacked composition of varieties of composite materials, the thickness of the obtained patch is macroscopically kept as the thickness of a pure PP patch, and the patch is lighter and thinner and has a great clinical application value.

Description

technical field [0001] The invention relates to the technical field of medical materials and their preparation. Specifically, the invention relates to the application of sodium hypochlorite in the preparation of single-layer double-sided polypropylene / polydopamine patches. Background technique [0002] Since the patch material was used in hernia repair, the recurrence rate of abdominal wall hernia decreased significantly, and the incidence of postoperative chronic pain also decreased. The patch used for intraperitoneal repair should meet the requirements of two sides, one side has an adhesion effect, and it fits closely with the peritoneum to reduce the risk of displacement; the other side has an anti-adhesion effect, which does not adhere to the organs in the abdominal cavity and reduces risk of intestinal obstruction and intestinal fistula. However, at present, most of the intra-abdominal meshes used clinically rely on imports, which are expensive and complicated to manuf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/16A61L27/18A61L27/50A61L27/56A61F2/00
CPCA61F2/0063A61L27/025A61L27/16A61L27/18A61L27/50A61L27/56C08L23/12C08L79/02
Inventor 林燕欢王辉吴丁财胡民辉黄榕康周铭洪过文泰杨梓锋秦秀森钟清华罗坚初丽丽叶新梅郭学峰吴小剑兰平汪建平
Owner SUN YAT SEN UNIV
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