The invention discloses a vacuum pumping tire segmental mold. The segmental mold comprises a base and a guide ring; a seal device is arranged between the lower end face of the guide ring and the upper end face of the base; the mold has the beneficial effects that exhaust is smooth, the dead corners of the mold are easily filled with tire compounds, the tire appearance is attractive, and the tire performance is good; the position between the guide ring and a mounting ring is subject to end face fixed seal, the seal effect is better, the service life of a seal ring is prolonged, and the material cost is reduced; the mold can be used by mounting rings in different shapes and with different types, and the adaptation is wide; meanwhile, components of the segmental mold are convenient to machine, the difficulty is low, the phenomenon that due to grooving in the guide ring, the strength is reduced is avoided, in addition, the phenomenon that a seal ring is placed on the lower end face of the guide ring, when the guide ring is placed and transported, the seal ring needs to be protected against damage caused by extrusion or collision is avoided, cost for machining and designing a new mold again is saved, a vacuum pumping mold of a new structure does not need to be designed again, the mold can be sealed, and the design and machining cost of the vacuum pumping mold is greatly reduced.