30results about How to "Prolonged disintegration time" patented technology

The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

The invention belongs to the technical field of medicinal preparations, and specifically relates to tenofovir disoproxil fumarate tablets. The tablets comprise tenofovir disoproxil fumarate, a filler, an adhesive, a disintegrating agent, a lubricant and a coating agent; each tablet is 600-800mg and contains 300mg of tenofovir disoproxil fumarate, 25-65% of the filler, 2-5% of the adhesive, 3-15% of the disintegrating agent, 1-3% of the lubricant and 2-3% of the coating agent. The tenofovir disoproxil fumarate tablets have the advantages of low cost and stable product quality.

The invention relates to a tablet containing faropenem sodium, belonging to the field of pharmaceutical preparation. The faropenem sodium tablet of the invention comprises 20-50 parts of faropenem sodium, 20-25 parts of disintegrant, 2-10 parts of 95% ethanol solution containing 5% of polyvinylpyrrolidone, 20-30 parts of filler and 0.5-2 parts of lubricant. The faropenem sodium tablet of the invention has the advantages of fast disintegration speed and stable properties in high-temperature and high-humidity environment, can effectively improve the effect-taking concentration and bioavailability of faropenem, and is very suitable for old people and children with dysphagia to take.

The invention discloses a pet's scourge-clearing toxin-vanquishing chewable tablet and a preparation process thereof. The pet's scourge-clearing toxin-vanquishing chewable tablet is composed of gypsum, rhizoma rehmanniae, cornu bubali, coptis chinensis, gardenia, moutan bark, scutellaria baicalensis, red peony, radix scrophulariae, rhizoma anemarrhenae, fructus forsythiae, lophatherum gracile, magnesium stearate, starch, extractum glycyrrhizae, ballonflower extractum and a flavoring agent. The preparation process is simple and includes three steps of preparing traditional Chinese medicine fine powder, preparing a mixed solution and mixing, pelletizing, tableting and forming. Compared with scourge-clearing toxin-vanquishing powder, the pet's scourge-clearing toxin-vanquishing chewable tablet has the advantages that a forming form of chewable tablet is adopted, traditional Chinese medicinal materials are subjected to smashing, tableting and forming, and extracted extractum glycyrrhizae and ballonflower extractum are adopted, so that dissolution, absorption and quick working of active ingredients are facilitated; medicine binding is realized through PVP (poly vinyl pyrrolidone), so that less proneness to moisture absorption is realized, efficacy can last longer, and full utilization of medicine is facilitated; mannitol used for flavoring can prevent the pet's scourge-clearing toxin-vanquishing chewable tablet from absorbing moisture, thereby having no hygroscopicity compared with common cane sugar, sorbitol and the like.

The invention provides pharmaceutical composition for edoxaban tablets. The composition is prepared from 10-50 parts of p-toluenesulfonic acid edoxaban monohydrate, 15-35 parts of a disintegrant, 2-10parts of a 5% polyvinylpyrrolidone 95% ethanol solution, 20-45 parts of filler and 0.5-2 parts of a lubricant, and has the advantages of high disintegration speed, high bioavailability, good stability and the like.

The invention discloses a spirulina tablet added with glycerol and a processing method thereof. The method comprises the following steps: uniformly mixing 60-120 meshes of the spirulina powder with the glycerol according to the mass percent rate of 100 : 1 to 3; and pressing in a tablet press of which the pressure is 10-20 tons to form the tablets. The glycerol has the function of reducing water activation, so the water activity of the product can be reduced after the glycerol is added in the spirulina powder, the storage time of the spirulina powder is effectively prolonged, and the number of microorganism is reduced.

The invention provides a caraway-containing compound capsule composition and a preparation method thereof. The content of the caraway-containing compound capsule composition consists of caraway oil, peppermint oil, sesame oil and olive oil. The caraway-containing compound capsule composition has the advantages of a short disintegrating time, high storage stability, high medicinal safety and the like.

This invention is framework core used to alimentary tract emptying function detection slow release pill and its preparation technique. The core includes following components and quality percentage: hard dissolve medicine using materials =30-90%, X ray developer =5-50%, disintegration using auxiliary materials =5-65%. The hard dissolve medicine using materials are ethyl cellulose, or cerotic acid cellulose, or high viscosity hydroxypropyl cellulose, or hydroxide third concha cellulose phthalidyl, or hydroxymethyl ethyl cellulose, or acrylic resin. The X ray developer is barium sulfate developer, or iodine developer. The disintegration using auxiliary materials are hydroxymethyl starch natrium, or crosslinked polyethylene pyrrolidone, or low substitution hydroxypropyl cellulose. its preparation technique main including getting framework core materials and suppress framework core. The core can be observed by X ray perspective equipment in alimentary canal, is has low speed slaking characteristic.

The invention relates to an irbesartan tablet and a preparation method thereof. The irbesartan tablet is prepared from the following raw materials in parts by mass: 150-450 parts of irbesartan, 15-50 parts of montmorillonite, 85-270 parts of sucrose, 0.5-1.5 parts of magnesium stearate and 0.5-1.5 parts of silicon dioxide. The invention also provides a preparation method of the irbesartan tablet. The irbesartan tablet disclosed by the invention, by matching special accessories and main drugs and through special proportions, can be used for solving the problems of existing drug particles which are poor in liquidity, non-ideal in drug disintegration, low in drug dissolution, poor in stability, not high in bioavailability in human body and the like.

The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

The invention relates to a concentrated compound natural indigo pill which is prepared from the following raw materials: natural indigo 60g, purslane 200g, dahurian angelica root 100g, poria cocos 200g, alkanna tinctoria 80g, basket fern 60g, dandelion 80g, root of red rooted saliva 100g, rhizoma dioscoreae hypoglaueae 100g, Chinese dittany bark 100g, smoked plum 200g, schisandra fruit 100g, haw 60g and medicated leaven 60g.

The invention discloses a spirulina tablet added with glycerol and a processing method thereof. The method comprises the following steps: uniformly mixing 60-120 meshes of the spirulina powder with the glycerol according to the mass percent rate of 100 : 1 to 3; and pressing in a tablet press of which the pressure is 10-20 tons to form the tablets. The glycerol has the function of reducing water activation, so the water activity of the product can be reduced after the glycerol is added in the spirulina powder, the storage time of the spirulina powder is effectively prolonged, and the number of microorganism is reduced.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention relates to an oxiracetam oral membrane preparation and a preparation method thereof. The oxiracetam oral dispersion membrane preparation is prepared from Oxiracetam, a membrane forming material, a plasticizing agent and a filling agent. The oxiracetam oral membrane preparation has the advantages that the preparation can be dissolved by less saliva in an oral cavity, and can be taken without using water, so that the taking is convenient; the easiness in vomiting is avoided after sticking onto a tongue, and the oxiracetam oral preparation is suitable for old people with difficulty in swallowing; by utilizing mucosae to absorb, the first pass elimination effect is avoided, the bioavailability is improved, the medicine dosage is reduced, and the side effect is decreased. The preparation method has the advantages that the preparation is simple, the technology cost is low, and the preparation method is suitable for industrialized production.

The invention provides a caraway-containing compound capsule composition and a preparation method thereof. The content of the caraway-containing compound capsule composition consists of caraway oil, peppermint oil, sesame oil and olive oil. The caraway-containing compound capsule composition has the advantages of a short disintegrating time, high storage stability, high medicinal safety and the like.

The invention discloses a production process of decoction pieces for dredging and reducing phlegm based on calcined concha arcae, and belongs to the technical field of traditional Chinese medicine decoction pieces, the calcined concha arcae is a monarch drug and is easily ground into powder after being calcined and quenched by adopting an acetic acid solution, and the calcined concha arcae powder is finer and more convenient to disperse after being ball-milled; the lucid ganoderma extract in the dry plaster powder contains ganoderan, so that the dry plaster powder has an anti-cancer effect and can prevent inflammatory cytopathy; the rhizoma gastrodiae has the effects of clearing and activating the channels and collaterals, and the pericarpium citri reticulatae has the effects of regulating qi-flowing for strengthening the spleen and eliminating dampness and phlegm and has fragrance, so that the decoction piece is more delicious; the loquat concentrated solution has the effects of moistening the lung to arrest cough, and the almonds also have the effects of relieving cough and asthma; the liquorice has the effects of expelling phlegm to arrest coughing and harmonizing all the medicines, the fried fructus gardeniae has the effects of cooling blood, detoxifying, diminishing swelling and the like, after the liquorice and the fried fructus gardeniae are further fried through the refined honey, the viscosity of the prepared refined honey medicine powder is increased, and after the liquorice and the fried fructus gardeniae are pressed into tablets, the disintegration time can be prolonged, and the medicine action time can be prolonged.

The invention provides a milk powder high-protein effervescent tablet and a preparation method thereof. The preparation method comprises the following steps: pelleting by using an acid-base separated type disintegrant, uniformly mixing base source granules and acid source granules, mixing with a lubricant, and performing compression molding. By adopting the preparation method provided by the invention, on the premise that the content of protein in the effervescent tablet is increased, the defects that a milk product has unstable properties, for example, the sticking and disintegration time is long, foams can be easily generated, and the like in a disintegration period can be remarkably overcome; the stability of a disintegrated product can be improved by innovatively changing the shape of the effervescent tablet and increasing the specific surface area, so that the disintegration time of the milk powder effervescent tablet can be effectively shortened, the stability of a protein system can be improved, and bubble and sticking phenomena in the disintegration process can be avoided; the milk powder high-protein effervescent tablet prepared by using the preparation method provided by the invention is high in disintegration speed, stable in product shape, applicable to various fast-moving consumption people, and capable of completely meeting industrial production demands.

The invention relates to a compound paracetamol and amantadine hydrochloride capsule and a preparation method thereof. The compound paracetamol and amantadine hydrochloride capsule disclosed by the invention is prepared from the following raw materials in parts by mass: 250-400 parts of paracetamol, 100-160 parts of amantadine hydrochloride, 10-16 parts of calculus bovis factitius, 15-24 parts of caffeine, 2-3.2 parts of chlorpheniramine maleate, 5-30 parts of montmorillonite, and 6-36 parts of cane sugar. By means of innovative accessory selection and optimized accessory proportion, the capsule dosage form is prepared; the problems of being poor in liquidity, non-ideal in drug disintegration, low in drug dissolution rate, poor in stability, not high in human bioavailability and the like in existing drug particles are solved.

The invention discloses a pet's scourge-clearing toxin-vanquishing chewable tablet and a preparation process thereof. The pet's scourge-clearing toxin-vanquishing chewable tablet is composed of gypsum, rhizoma rehmanniae, cornu bubali, coptis chinensis, gardenia, moutan bark, scutellaria baicalensis, red peony, radix scrophulariae, rhizoma anemarrhenae, fructus forsythiae, lophatherum gracile, magnesium stearate, starch, extractum glycyrrhizae, ballonflower extractum and a flavoring agent. The preparation process is simple and includes three steps of preparing traditional Chinese medicine fine powder, preparing a mixed solution and mixing, pelletizing, tableting and forming. Compared with scourge-clearing toxin-vanquishing powder, the pet's scourge-clearing toxin-vanquishing chewable tablet has the advantages that a forming form of chewable tablet is adopted, traditional Chinese medicinal materials are subjected to smashing, tableting and forming, and extracted extractum glycyrrhizae and ballonflower extractum are adopted, so that dissolution, absorption and quick working of active ingredients are facilitated; medicine binding is realized through PVP (poly vinyl pyrrolidone), so that less proneness to moisture absorption is realized, efficacy can last longer, and full utilization of medicine is facilitated; mannitol used for flavoring can prevent the pet's scourge-clearing toxin-vanquishing chewable tablet from absorbing moisture, thereby having no hygroscopicity compared with common cane sugar, sorbitol and the like.

The present invention relates to a sustained-release oral disintegrating film having excellent oral mucosa adhesion, which contains a component with improved oral mucosa adhesion to allow efficient introduction of effective ingredients contained in an oral mucosa film through a capillary inside a mucosal layer since long-term attachment can be performed when being attached to the oral mucosa for use, and a disintegration time can be delayed by oral saliva by increasing adhesion for oral mucosa through a combination of chitosan or a compound thereof and glutathione with respect to components ofan oral mucosa attachable sustained-release oral disintegrating film, and being formed by coating ethyl cellulose exhibiting hydrophobic characteristics on one side of the film, and to a manufacturing method thereof. In addition, the sustained-release oral disintegrating film is purposed for a health functional food or medicine and medical supplies by appropriately mixing and combining effectiveingredients having various functional effects on the basis of film base ingredients secured in the present invention.

The invention discloses a phenoxybenzylamine hydrochloride tablet which comprises the following components: phenoxybenzylamine hydrochloride, dextrin, pregelatinized starch, a disintegrating agent, afilling agent, an adhesive, a lubricating agent and a flow aid. The viscosity of the dextrin ranges from 4.5 mpa.s to 8.5 mpa.s; the specific surface area of the pregelatinized starch is less than orequal to 350m < 2 > / kg; the disintegrating agent is carboxymethyl starch sodium. A disintegrating agent such as carboxymethyl starch sodium, dextrin with viscosity of 4.5-8.5 mpa.s and pregelatinizedstarch with specific surface area of less than or equal to 350m < 2 > / kg are added into the components, so that the obtained phenoxybenzamine hydrochloride tablet has improved dissolution rate and dissolution rate uniformity, and is small in intra-group difference and good in stability.

This invention is framework core used to alimentary tract emptying function detection slow release pill and its preparation technique. The core includes following components and quality percentage: hard dissolve medicine using materials =30-90%, X ray developer =5-50%, disintegration using auxiliary materials =5-65%. The hard dissolve medicine using materials are ethyl cellulose, or cerotic acid cellulose, or high viscosity hydroxypropyl cellulose, or hydroxide third concha cellulose phthalidyl, or hydroxymethyl ethyl cellulose, or acrylic resin. The X ray developer is barium sulfate developer, or iodine developer. The disintegration using auxiliary materials are hydroxymethyl starch natrium, or crosslinked polyethylene pyrrolidone, or low substitution hydroxypropyl cellulose. its preparation technique main including getting framework core materials and suppress framework core. The core can be observed by X ray perspective equipment in alimentary canal, is has low speed slaking characteristic.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a levetiracetam tablet and a preparation method thereof. The preparation method comprises the following steps: 1, sieving levetiracetam, hydroxypropyl cellulose, croscarmellose sodium and part of colloidal silicon dioxide together for later use; 2, mixing the granulated materials in the step 1, adding magnesium stearate, and uniformly mixing to obtain premixed powder; 3, the premixed powder in the step 2 being subjected to dry granulation and size stabilization, and obtaining a particle and powder mixture; 4, mixing the granules and powder mixture granulated in the step 3 with the residual colloidal silicon dioxide, and tabletting; and 5, coating. The preparation method provided by the invention has the characteristics of simple process flow, strong operability, low production cost and stability.