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Irbesartan tablet and preparation method thereof

A technology for irbesartan tablets and irbesartan, applied in the field of medicine, can solve the problems of low bioavailability of human body, poor particle fluidity, unsatisfactory drug disintegration, etc., and reduce the types and use of excipients The effect of increasing the disintegration rate, increasing the disintegration rate and high dissolution rate

Active Publication Date: 2015-11-25
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the combination of specific excipients and the main drug, as well as the specific ratio, the problems of poor fluidity of the existing drug particles, unsatisfactory drug disintegration, low drug dissolution, poor stability and low bioavailability of the human body are solved.

Method used

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  • Irbesartan tablet and preparation method thereof
  • Irbesartan tablet and preparation method thereof
  • Irbesartan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Embodiment 1: the preparation of irbesartan tablet

[0116] Irbesartan tablets are made from the following raw materials in parts by mass:

[0117]

[0118] The preparation method is as follows:

[0119] (1) Irbesartan, sucrose, and montmorillonite are pulverized; wherein irbesartan is passed through a 90-mesh sieve for subsequent use; sucrose is passed through a 120-mesh sieve for subsequent use; montmorillonite is passed through a 350-mesh sieve for subsequent use;

[0120] (2) adding 95% (w / w) medicinal ethanol to purified water to prepare 75-80% (w / w) ethanol aqueous solution, and set aside;

[0121] (3) Take irbesartan, sucrose, and montmorillonite according to the proportioning ratio, mix well, then add the 75-80% (w / w) ethanol aqueous solution prepared in step (2), stir and mix evenly to make a soft material , and sieved to obtain wet granules;

[0122] (4) Dry the wet granules prepared in step (3) at 50-52° C. for 1.5 hours, detect the moisture content of ...

Embodiment 2

[0126] The preparation of embodiment 2 irbesartan tablets:

[0127] Irbesartan tablets are made from the following raw materials in parts by mass:

[0128]

[0129]

[0130] The preparation method is as follows:

[0131] (1) Irbesartan, sucrose, and montmorillonite are pulverized; wherein irbesartan is passed through a 80-mesh sieve for subsequent use; sucrose is passed through a 110-mesh sieve for subsequent use; montmorillonite is passed through a 400-mesh sieve for subsequent use;

[0132] (2) adding 95% (w / w) medicinal ethanol to purified water to prepare 75-80% (w / w) ethanol aqueous solution, and set aside;

[0133] (3) Take irbesartan, sucrose, and montmorillonite according to the proportioning ratio, mix well, then add the 75-80% (w / w) ethanol aqueous solution prepared in step (2), stir and mix evenly to make a soft material , and sieved to obtain wet granules;

[0134] (4) Dry the wet granules prepared in step (3) at 53-55° C. for 1 hour, detect that the moistur...

Embodiment 3

[0138] The preparation of embodiment 3 irbesartan tablets:

[0139] Irbesartan tablets are made from the following raw materials in parts by mass:

[0140]

[0141] The preparation method is as follows:

[0142] (1) Irbesartan, sucrose, and montmorillonite are pulverized; wherein irbesartan is passed through a 80-mesh sieve for subsequent use; sucrose is passed through a 130-mesh sieve for subsequent use; montmorillonite is passed through a 370-mesh sieve for subsequent use;

[0143] (2) adding 95% (w / w) medicinal ethanol to purified water to prepare 75-80% (w / w) ethanol aqueous solution, and set aside;

[0144] (3) Take irbesartan, sucrose, and montmorillonite according to the proportioning ratio, mix well, then add the 75-80% (w / w) ethanol aqueous solution prepared in step (2), stir and mix evenly to make a soft material , and sieved to obtain wet granules;

[0145] (4) Dry the wet granules prepared in step (3) at 52-54° C. for 1.2 hours, detect the moisture content of...

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Abstract

The invention relates to an irbesartan tablet and a preparation method thereof. The irbesartan tablet is prepared from the following raw materials in parts by mass: 150-450 parts of irbesartan, 15-50 parts of montmorillonite, 85-270 parts of sucrose, 0.5-1.5 parts of magnesium stearate and 0.5-1.5 parts of silicon dioxide. The invention also provides a preparation method of the irbesartan tablet. The irbesartan tablet disclosed by the invention, by matching special accessories and main drugs and through special proportions, can be used for solving the problems of existing drug particles which are poor in liquidity, non-ideal in drug disintegration, low in drug dissolution, poor in stability, not high in bioavailability in human body and the like.

Description

technical field [0001] The invention relates to an irbesartan tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] According to the statistics of hypertension in China in 2002, the prevalence of hypertension among adults in my country has reached 18.8%, and the total number of people with hypertension in the country has reached nearly 160 million. Various complications caused by hypertension are an important cause of death from cerebrovascular diseases. Therefore, how to effectively prevent and treat hypertension and reduce or reduce various complications caused by hypertension is an important measure to improve the quality of our population and reduce the mortality rate of cardiovascular and cerebrovascular diseases. [0003] Irbesartan is an angiotensin Ⅱ (Angiotensin Ⅱ, Ang Ⅱ) receptor inhibitor, which can inhibit the conversion of Ang Ⅰ to Ang Ⅱ, and can specifically antagonize the angiotensin converting en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4184A61K47/26A61K47/04A61P9/12
Inventor 乔敏刘钢李红新邵兰兰孟震晓
Owner SHANDONG SBOND PHARMA
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