Skeleton tablet core for digestive tract evacuation-detecting slow-release tablet and its preparing process

A technology of skeleton tablets and digestive tract, applied in the direction of emulsion delivery, drug delivery, etc., can solve the problems that cannot meet the requirements of simulated capsules, and achieve the effect of low disintegration rate

Inactive Publication Date: 2006-08-09
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The digestive tract emptying test sustained-release tablet with an extremely low disintegration rate can meet the above requirements. The matrix core is the key to realize the low-speed sustained-release function. The disintegration time of the current matrix core design is basically based on the normal emptying time of the human body Designed to be completely disintegrated within the normal digestive tract emptying time range, unable to meet the requirements of simulated capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Prepare the skeleton core material: according to the quantity of the skeleton core to be prepared, weigh the skeleton according to the mass ratio of ethyl cellulose=60%, barium sulfate developer=15%, sodium hydroxymethyl starch=25% Tablet core material, placed in the stirrer;

[0016] 2) Compressing the skeleton core: add distilled water with 20% quality of the skeleton core material to the skeleton core material, mix evenly, utilize a medicinal tablet press and a skeleton core mold to press into a skeleton core, put the skeleton core into Dry in an oven at 40°C for 12 hours, or dry naturally at room temperature.

Embodiment 2

[0018] 1) Prepare the skeleton core material: according to the quantity of the skeleton core to be prepared, weigh the skeleton according to the mass ratio of cellulose cerate=70%, barium sulfate developer=15%, and cross-linked polyvinylpyrrolidone=15%. Tablet core material, placed in the stirrer;

[0019] 2) Pressing the skeleton core: add distilled water with 25% quality of the skeleton core material to the skeleton core material, mix evenly, utilize a medicinal tablet press and a skeleton core mold to press into a skeleton core, put the skeleton core into Dry in an oven at 50°C for 10 hours, or dry naturally at room temperature.

Embodiment 3

[0021] 1) Prepare the skeleton core material: according to the quantity of the skeleton core to be prepared, according to high viscosity hydroxypropyl cellulose=75%, barium sulfate developer=10%, low-substituted hydroxypropyl cellulose=15% Mass ratio Take the skeleton core material and place it in the stirrer:

[0022] 2) Compressing the skeleton core: add distilled water with 40% quality of the skeleton core material to the skeleton core material, mix evenly, utilize a medicinal tablet press and a skeleton core mold to press into a skeleton core, put the skeleton core into Dry in an oven at 70°C for 6 hours, or dry naturally at room temperature.

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PUM

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Abstract

This invention is framework core used to alimentary tract emptying function detection slow release pill and its preparation technique. The core includes following components and quality percentage: hard dissolve medicine using materials =30-90%, X ray developer =5-50%, disintegration using auxiliary materials =5-65%. The hard dissolve medicine using materials are ethyl cellulose, or cerotic acid cellulose, or high viscosity hydroxypropyl cellulose, or hydroxide third concha cellulose phthalidyl, or hydroxymethyl ethyl cellulose, or acrylic resin. The X ray developer is barium sulfate developer, or iodine developer. The disintegration using auxiliary materials are hydroxymethyl starch natrium, or crosslinked polyethylene pyrrolidone, or low substitution hydroxypropyl cellulose. its preparation technique main including getting framework core materials and suppress framework core. The core can be observed by X ray perspective equipment in alimentary canal, is has low speed slaking characteristic.

Description

Technical field: [0001] The invention relates to a skeleton tablet core used for a sustained-release tablet for detecting gastrointestinal emptying and a preparation process thereof. Background technique: [0002] With the development of microelectronics, integrated circuits and other technologies, electronic capsules, as a new type of digestive tract diagnosis and treatment product, have gradually entered clinical applications, such as capsule endoscopy, electronic capsules for fixed-point drug application, and electronic capsules for digestive tract detection. One of the common features of the products is that the shell of the electronic capsule is made of medical plastic or stainless steel that cannot be degraded in the digestive tract. There are serious hidden dangers in the use of these products: electronic capsules may block the digestive tract. Once the electronic capsule cannot be discharged from the digestive tract, if the electronic capsule is still in the stomach...

Claims

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Application Information

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IPC IPC(8): A61K49/18
Inventor 皮喜田郑小林刘洪英侯文生周承文彭承琳陈峰刘洋崔建国吴旭东
Owner CHONGQING UNIV
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