Preparation method and application of a conductive hydrogel capable of sustained release of drugs and factors

A conductive hydrogel and slow-release drug technology, applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as shortening the electron transfer process, limiting applications, and low drug concentration in lesion parts, achieving Increase the effect of immobilized bioactive growth factors, stabilize metal organic framework structure, and improve electrochemical activity

Inactive Publication Date: 2021-01-29
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the in vivo environment is relatively complex, and the drug contained in the metal-organic framework is prone to structural disintegration during the process of delivery to the lesion, resulting in drug loss, making the drug concentration in the lesion too low to achieve the desired curative effect; on the other hand , metal organic framework materials have a unique pore structure, which can buffer the volume expansion of electrodes, increase the contact area between substrate and product and electrolyte, and shorten the electron transfer process; metal organic framework materials have great potential in the field of bioelectrodes; but metal Organic framework materials inherently have poor electrical conductivity, which limits their applications
[0003] The existing metal organic framework materials have the following problems: metal organic framework drug loading is easy to lose when transported in vivo, resulting in low drug concentration in the lesion; the poor conductivity and stability of metal organic framework materials limit their application in bioelectrodes. and other applications

Method used

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  • Preparation method and application of a conductive hydrogel capable of sustained release of drugs and factors
  • Preparation method and application of a conductive hydrogel capable of sustained release of drugs and factors

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preparation example Construction

[0027] The preparation method of the conductive hydrogel capable of sustained release of medicines and factors comprises the following steps:

[0028] Step 1: Prepare a conductive polymer monomer solution with a mass concentration of 0.04-2%, add an oxidizing agent, stir and react at 0-5°C for 4-10 days, perform centrifugal cleaning several times after sufficient reaction, and obtain a conductive polymer polymer material; the mass ratio of the conductive polymer monomer to the oxidizing agent is 1:1~20; the oxidizing agent is one of ferric chloride, ferric nitrate, ferric sulfate and ammonium ferric sulfate; the conductive polymer monomer is pyrrole monomer, One of aniline monomers, thiophene monomers and 5-carboxyindole monomers.

[0029] Step 2: Prepare a dopamine aqueous solution with a concentration of 0.05-10 mg / mL, adjust the pH to 8-13 with ammonia water or trisaminomethane buffer solution; add the conductive polymer obtained in step 1, and stir at room temperature for ...

Embodiment 1

[0039] A preparation method of conductive hydrogel, comprising the following steps:

[0040] A, preparation of polydopamine / poly 3,4-ethylenedioxythiophene complex

[0041]Dissolve 266 μL of 3,4-ethylenedioxythiophene monomer in 30 mL of absolute ethanol to obtain a solution with a mass concentration of 1.5% of 3,4-ethylenedioxythiophene monomer; add 7 g of trichloride to the above solution iron, stirred and reacted at 0-5°C for 5 days; the solution after the above reaction was centrifuged and washed several times with deionized water to obtain poly-3,4-ethylenedioxythiophene particles; dopamine was dissolved in deionized water to obtain A dopamine solution with a concentration of 0.5 mg / mL, the pH of the above solution was adjusted to 8.5 with ammonia water; then, poly-3,4-ethylenedioxythiophene particles were added to the above solution, stirred at room temperature for 12 hours, and washed several times to obtain poly Dopamine / poly-3,4-ethylenedioxythiophene complex.

[00...

Embodiment 2

[0050] A, preparation of polydopamine / polypyrrole complex

[0051] Dissolve 190 μL of pyrrole monomer in 40 mL of absolute ethanol to obtain a solution with a mass concentration of 0.58% pyrrole monomer; add 5 g of iron sulfate to the above solution, and stir and react at 0-5°C for 3 days; The final solution was centrifuged and washed 3 times with deionized water to obtain polypyrrole particles; dopamine was dissolved in deionized water to obtain a solution with a dopamine concentration of 0.4 mg / mL, and the pH of the above solution was adjusted to 8.5 with trisaminomethane buffer. ; Then, add polypyrrole particles to the above solution, stir at room temperature for 12 hours, and wash several times to obtain a polydopamine / polypyrrole complex.

[0052] B, Preparation of ZIF-7 / polydopamine / polypyrrole complex

[0053] Dissolve zinc acetate in N,N-dimethylformamide to obtain a solution with a mass concentration of zinc acetate of 2.15%; dissolve benzimidazole in methanol to obt...

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Abstract

The invention discloses a preparation method and application of a conductive hydrogel that can release medicines and factors slowly, comprising the following steps: Step 1: preparing a conductive polymer monomer solution, adding an oxidant, and fully reacting to obtain a conductive polymer; Step 2: Prepare a concentrated dopamine aqueous solution, add the conductive polymer obtained in step 1, and obtain a polydopamine / conductive polymer compound after sufficient reaction; Step 3: Prepare a metal ion salt solution and an organic ligand solution; Step 4 : Add polydopamine / conductive polymer complex to metal ion salt solution, after mixing evenly, add organic ligand solution; fully react; step 5: compound of metal organic framework / polydopamine / conductive polymer , adding monomers or double-bonded biomacromolecule solutions; adding additives and then polymerizing to form required hydrogels; the invention has excellent electrical conductivity and electrochemical activity, and can be used for the preparation of drug carriers and bioelectrodes.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method and application of a conductive hydrogel capable of sustained release of drugs and factors. Background technique [0002] In recent years, metal-organic frameworks have been widely used as drug carriers because of their advantages such as large surface area, adjustable pore size, moderate pore volume, and high porosity; high specific surface area can load biomacromolecules, and large pore size can encapsulate different types of drugs , and the drug loading is large. However, the in vivo environment is relatively complex, and the drug contained in the metal-organic framework is prone to structural disintegration during the process of delivery to the lesion, resulting in drug loss, making the drug concentration in the lesion too low to achieve the desired curative effect; on the other hand , metal organic framework materials have a unique pore structure, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L87/00C08L79/04C08L65/00C08L79/02A61K9/00A61K9/06A61K31/43A61K31/4409A61K31/573A61K31/737A61K38/18A61K38/30A61K47/02A61K47/32A61K47/34
CPCA61K9/0009A61K9/06A61K31/43A61K31/4409A61K31/573A61K31/737A61K38/1875A61K38/30A61K47/02A61K47/32A61K47/34C08J3/075C08J2365/00C08J2379/02C08J2379/04C08J2387/00C08J2465/00C08J2479/02C08J2479/04C08J2487/00
Inventor 鲁雄黄自强甘东林闫力维王笑
Owner SOUTHWEST JIAOTONG UNIV
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