Coating agent containing hydroxyalkyl cellulose

A technology of hydroxyalkyl cellulose and coating agent, which is applied in the direction of non-active ingredient medical preparations, pill delivery, sugar-coated pills, etc., to achieve the effect of high hardness

Inactive Publication Date: 2016-01-27
NIPPON SODA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sometimes the coating film of the hydroxyalkyl cellulose suffers from agglomeration called caking.

Method used

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  • Coating agent containing hydroxyalkyl cellulose
  • Coating agent containing hydroxyalkyl cellulose
  • Coating agent containing hydroxyalkyl cellulose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Preparation of plain tablets

[0052] 70 parts by mass of lactose for direct compression, 30 parts by mass of cornstarch, and 0.5 parts by mass of magnesium stearate were mixed, and a tablet press (VELA5) manufactured by Kikusui Seisakusho Co., Ltd. was used to compress the tablet at a pressure of 10 kN and a tablet size Under the condition of 8mmφ-R sheet (200mg / T), carry out tablet molding, manufacture plain sheet.

[0053] The preparation of hydroxypropyl cellulose (A)

[0054] 176 g of pulverized pulp was placed in a reactor equipped with a stirrer, and 68.2 g of a 20% NaOH aqueous solution was added thereto, followed by adding 602 g of toluene. After stirring for 30 minutes, the temperature in the reactor was adjusted to 30°C. Stirring the inside of the reactor was pressurized with nitrogen, and a mercerization reaction was performed for 1 hour.

[0055] After decompression, propylene oxide was added. The amount of propylene oxide added at this time was 4.92 as...

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Abstract

Obtained is a coating agent that contains a hydroxyalkyl cellulose, which contains more than 50% by mass but 60% by mass or less of a hydroxy alkyl group relative to the total mass of the hydroxyalkyl cellulose, in an amount of from 1% by mass to 7% by mass (inclusive) relative to the total mass of the coating agent. A solid preparation is obtained by spraying this coating agent onto a base tablet and drying this coating agent thereon.

Description

technical field [0001] The present invention relates to a coating agent containing hydroxyalkylcellulose. More specifically, the present invention relates to a coating agent suitable for obtaining a coating film of a solid preparation for medicine, agricultural chemicals or food. [0002] this application claims priority based on Japanese Patent Application No. 2013-126671 for which it applied to Japan on June 17, 2013, and uses the content here. Background technique [0003] Hydroxypropyl cellulose is glucose (C 6 h 10 o 5 ) The nonionic polymer obtained by etherification of the hydroxyl group in the unit. Hydroxypropyl cellulose is known to include hydroxypropyl cellulose with a hydroxypropyl content of 53.4 to 77.5% by mass, hydroxypropyl cellulose with a hydroxypropyl content of 40 to 50% by mass, and hydroxypropyl cellulose with a hydroxypropyl content of 5 to 16% by mass. base cellulose. In general, hydroxypropyl cellulose having a content of 5 to 16% by mass is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K9/36
CPCA61K47/38A61K9/2866
Inventor 梅泽忠霜鸟武司津江晋一郎
Owner NIPPON SODA CO LTD
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