Coating agent containing hydroxyalkyl cellulose
A technology of hydroxyalkyl cellulose and coating agent, which is applied in the direction of non-active ingredient medical preparations, pill delivery, sugar-coated pills, etc., to achieve the effect of high hardness
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[0051] Preparation of plain tablets
[0052] 70 parts by mass of lactose for direct compression, 30 parts by mass of cornstarch, and 0.5 parts by mass of magnesium stearate were mixed, and a tablet press (VELA5) manufactured by Kikusui Seisakusho Co., Ltd. was used to compress the tablet at a pressure of 10 kN and a tablet size Under the condition of 8mmφ-R sheet (200mg / T), carry out tablet molding, manufacture plain sheet.
[0053] The preparation of hydroxypropyl cellulose (A)
[0054] 176 g of pulverized pulp was placed in a reactor equipped with a stirrer, and 68.2 g of a 20% NaOH aqueous solution was added thereto, followed by adding 602 g of toluene. After stirring for 30 minutes, the temperature in the reactor was adjusted to 30°C. Stirring the inside of the reactor was pressurized with nitrogen, and a mercerization reaction was performed for 1 hour.
[0055] After decompression, propylene oxide was added. The amount of propylene oxide added at this time was 4.92 as...
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