The invention relates anti-virus polyurethane material and a preparation method thereof, pertains to polymer material field. The material is polyurethane with monomer containing fluorin inserted into the main chain. The method uses materials including: benzophenone (I), isopropanol (II), polymeric diatomic alcohol (III), diisocyanate (IV), 2,2,3,4,4,4-Hexafluorobutyl acrylate (V) and vinylpyrrolidone;n-vinyl pyrrolidone (VI). The method including steps of: mixing material I and II, charging first catalyst, reacting under radiation of ultraviolet to obtain product of 1,1,2,2-tetraphenyl-1,2-ethanediol, recrystallizing and purifying by acetic acid, adding mixture of material III and IV into the solvent, stirring while reacting to obtain prepolymer; adding 1,1,2,2-tetraphenyl-1,2-ethanediol once more to get reactant, adding second catalyst, purifying to get polyurethane with 1,1,2,2-tetraphenyl-1,2-ethanediol, mixing it with material V and VI, and purifying to get fluorinated polyurethane. The invention has a long-term anti-virus effect.