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Special chitosan derivative-based water-free hand washing liquid for children, and preparation method thereof

A technology of chitosan derivatives and hand sanitizer, which is applied in the field of daily chemical industry, can solve the problems of children's skin allergies and unsatisfactory biological safety, and achieve the effects of long effective time, reasonable formula, convenient use and carrying

Pending Publication Date: 2017-12-22
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological safety of water-free hand sanitizers for children in the domestic consumer market is not satisfactory, and some of them may even cause skin allergies in children after use, which brings great distress to children and parents.

Method used

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  • Special chitosan derivative-based water-free hand washing liquid for children, and preparation method thereof
  • Special chitosan derivative-based water-free hand washing liquid for children, and preparation method thereof
  • Special chitosan derivative-based water-free hand washing liquid for children, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Prepare and synthesize the material described in formula (1) of the present invention:

[0092] Take by weighing 0.1 gram of chitosan and join in 100 milliliters of deionized water, mechanically stir at room temperature for half an hour, so that chitosan dissolves completely, thereby obtain the homogeneous solution that mass volume percent concentration is 0.1%; Slowly add thiourea trioxide into the system, the molar ratio of thiourea trioxide and chitosan is 10:1, the feeding time is 30 minutes, and the reaction at room temperature is kept for 60 minutes; A mixed solution of amino acid, N-hydroxysuccinimide (NHS) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) (solvent: 30mmol / L of 2-(N-morpholino)ethanesulfonic acid (MES) buffer solution) 20ml was added to the above-mentioned reaction solution, and the stirring reaction was continued at room temperature for 48 hours, wherein chitosan, arginine, NHS, EDC The molar ratio of the solution is 50...

Embodiment 2

[0096] Prepare and synthesize the material described in formula (2) of the present invention:

[0097] Weigh 0.1g carboxymethyl chitosan (the number average molecular weight is 2×10 5Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 100%), add 100mL deionized water, and mechanically stir evenly at room temperature, so that carboxymethyl chitosan is completely dissolved, thereby obtaining a mass volume percent concentration of 0.1% solution; weigh 2,3-epoxypropyltrimethylammonium chloride, dissolve in 50mL deionized water, and stir mechanically at room temperature; Ammonium chloride solution was slowly added into the carboxymethyl chitosan solution in 3 times, and the feeding time was 4 hours, and then stirred at constant temperature for 4 hours; Adjust the pH value of the solution to 5.0 and the salt concentration to 0.01M to obtain solution S1; weigh NHS and EDC (molar ratio is 1:10), dissolve in 30mL 0.01M pH 5.0 MES / HCl buffer solutio...

Embodiment 3

[0101] Prepare and synthesize the material described in formula (3) of the present invention:

[0102] Weigh 0.35g carboxymethyl chitosan (the number average molecular weight is 2×105Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 95%), add 35mL deionized water, and stir mechanically at room temperature to make the carboxymethyl chitosan Polysaccharides were completely dissolved to obtain a solution with a concentration of 1% by mass volume; weigh NHS and EDC (molar ratio 1:1), and dissolve them in 15mL 0.01M pH 5.0 MES / HCl buffer solution to obtain a catalyst solution; weigh Add arginine to the catalyst solution for activation, and stir at room temperature for 1 hour; pour the arginine activation solution into the carboxymethyl chitosan solution for 3 times, and react for 24 hours under stirring at 45°C; Hydroxylamine hydrochloride with an equimolar ratio of arginine was added to the reaction solution to terminate the reaction; the rea...

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Abstract

The invention discloses a special chitosan derivative-based water-free hand washing liquid for children, and a preparation method thereof, wherein the special chitosan derivative-based water-free hand washing liquid comprises the following raw materials by weight: 0.1-5 parts of a chitosan derivative, 0.01-1 part of a viscosity modifier, 1-10 parts of glycerin, 0.01-1 part of a skin-care agent, 0.01-0.5 part of a surfactant, and 100 parts of deionized water. According to the present invention, the water-free hand washing liquid with advantages of safety, no harm to human body, environmental protection and efficient antibacterial property is prepared by using the chitosan derivative macromolecule having the antibacterial function group as the active substance; and the water-free hand washing liquid designed for the children skin has the reasonable formula, can form the protective film on the child hand surface after the use, can kill a variety of pathogenic bacteria in children, and has characteristics of strong antibacterial ability, long acting time, no color, no odor, no toxicity, no irritating, smoothness and comfort after the use, no requirement of water rinsing, convenient use, and convenient carrying.

Description

technical field [0001] The invention relates to the field of daily chemical technology. More specifically, it relates to a water-free hand sanitizer for children. Background technique [0002] Hand sanitizer, as the name suggests, is mainly used to wash hands, to clean and protect the skin of hands. In daily life and work, adults usually wash their hands in the presence of water. After using hand sanitizer, it needs to be cleaned with water just like general soap. On the one hand, children's skin is different from that of adults. They are sensitive to the surrounding environment and relatively weak in resistance, so they naturally have high requirements for skin cleaning products; In many occasions when handwashing is urgently needed, it is not easy to find a water source, such as traveling, taking a car, especially when children enter public places, in this case, there is a need for water-free handwashing and relatively high safety. Washing products. However, although g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/73A61K8/67A61K8/34A61Q19/10A61Q17/00C08B37/08
CPCA61K8/345A61K8/673A61K8/678A61K8/736A61K8/922A61K2800/5922A61K2800/596A61K2800/84A61Q17/005A61Q19/10C08B37/003
Inventor 牛忠伟蒋士冬吴曼
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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