Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antibacterial hydrogel with controllable released nano silver ions and preparation method thereof

A nano-silver particle and hydrogel technology, which is applied in the field of biomedical engineering composite biomaterials, can solve the problems that implants cannot achieve antibacterial or antibacterial effects, and achieve the goals of improving toxicity, long-term antibacterial effects, and promoting repair and regeneration. Effect

Inactive Publication Date: 2019-05-17
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, since the pores of the hydrogel are mostly micron or submicron, silver nanoparticles can easily penetrate these pores and quickly escape to the outside of the scaffold material, resulting in the inability of the implant to achieve long-term antibacterial or bacteriostatic effect. Effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antibacterial hydrogel with controllable released nano silver ions and preparation method thereof
  • Antibacterial hydrogel with controllable released nano silver ions and preparation method thereof
  • Antibacterial hydrogel with controllable released nano silver ions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of an antibacterial hydrogel with controllable release of nano silver ions:

[0045] 1) Mix the modified nano-silver-loaded microspheres and UV-sensitive modified gelatin with a mass fraction of 8% according to a mass ratio of 1:40 to form a prepolymer solution, and add photoinitiator 2-hydroxyl to the prepolymer solution - 4′-(2-hydroxyethoxy)-2-methylpropiophenone is mixed evenly, and the mass volume ratio (w / v) of the photoinitiator to the prepolymer solution is 1%.

[0046] 2) After repeatedly blowing and mixing the solution obtained in 1), take 150 μl of the solution and drop it into the photocrosslinking model, and place it under ultraviolet light (wavelength of external light source: 320-480nm, power of ultraviolet point light source: 7.0mW / cm 2 ) under cross-linking for 30 seconds and then removed to obtain an antibacterial hydrogel.

Embodiment 2

[0048] 1) Mix the modified nano-silver-loaded microspheres and UV-sensitive modified gelatin with a mass fraction of 8% according to the mass ratio of 1:80 to form a prepolymer solution, and add photoinitiator 2-hydroxyl to the prepolymer solution -4′-(2-hydroxyethoxy)-2-methylpropiophenone is mixed evenly, and the mass volume ratio (g / ml) of the photoinitiator to the prepolymer solution is 1%.

[0049] 2) After repeatedly blowing and mixing the solution obtained in 1), take 150 μl of the solution and drop it into the photocrosslinking model, and place it under ultraviolet light (wavelength of external light source: 320-480nm, power of ultraviolet point light source: 7.0mW / cm 2 ) under cross-linking for 30 seconds and then removed to obtain an antibacterial hydrogel.

Embodiment 3

[0051] 1) Mix the modified nano-silver-loaded microspheres and UV-sensitive modified gelatin with a mass fraction of 8% according to the mass ratio of 1:160 to form a prepolymer solution, and add photoinitiator 2-hydroxyl to the prepolymer solution -4′-(2-hydroxyethoxy)-2-methylpropiophenone is mixed evenly, and the mass volume ratio (g / ml) of the photoinitiator to the prepolymer solution is 1%.

[0052] 2) After repeatedly blowing and mixing the solution obtained in 1), take 150 μl of the solution and drop it into the photocrosslinking model, and place it under ultraviolet light (wavelength of external light source: 320-480nm, power of ultraviolet point light source: 7.0mW / cm 2 ) under cross-linking for 30 seconds and then removed to obtain an antibacterial hydrogel.

[0053] The antimicrobial hydrogel with controllable release of nano-silver ions obtained in Example 2 when the mass ratio of modified microspheres to gelatin was 1:80 was analyzed by scanning electron microscop...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Heightaaaaaaaaaa
Wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention provides an antibacterial hydrogel with controllable released nano silver ions and a preparation method thereof. The preparation method comprises the following steps: 1, mixing modifiednano silver-loaded microspheres and a modified gelatin solution to form a prepolymer solution, adding a photoinitiator into the prepolymer solution, and uniformly mixing them; 2, putting the solutionobtained in the step 1 in a mold, carrying out photocrosslinking gelation under an ultraviolet light source to obtain the antibacterial hydrogel. The prepared hydrogel with controllable released nanosilver ions can effectively improve the toxic effect of the nano silver particles on tissue cells and achieve long-acting antibacterial and bacteriostatic functions, thereby promoting complete tissuerepair and regeneration.

Description

technical field [0001] The invention belongs to the field of biomedical engineering composite biological materials, and in particular relates to an antibacterial hydrogel with controllable release of nanometer silver ions and a preparation method thereof. Background technique [0002] At present, some biomaterials with superior physical and chemical properties and good biocompatibility are widely used in clinical medicine, but the main reason restricting the development of biomaterials is biomaterial-centered infection (BCI), and biomaterial-centered infection (BCI) is a serious problem associated with the clinical use of biomaterials, which can even lead to surgical failure and have a significant impact on patient outcomes. Bacterial adhesion, reproduction, and bacterial biofilm formation on the surface of biological materials are the main causes of BCI. [0003] Since the bacteria in the biofilm are significantly different from those of ordinary planktonic bacteria in ter...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/52A61L27/54A61L27/04A61L27/22
Inventor 肖文谦李克江曲晓航刘爽李波
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com