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Antibiotic polyurethane material and preparation method thereof

A polyurethane material and polyurethane technology, applied in the field of preparation of antibacterial polyurethane materials, can solve problems such as lack of antibacterial effect, achieve long-term antibacterial effect, easy to realize, and simple preparation method

Inactive Publication Date: 2008-08-13
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel lacks antimicrobial activity

Method used

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  • Antibiotic polyurethane material and preparation method thereof
  • Antibiotic polyurethane material and preparation method thereof
  • Antibiotic polyurethane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step 1): Benzophenone (0.1mol; 18.20g) and isopropanol (0.5mol) were mixed first, then acetic acid (0.005mol; 0.03g) was added, and the mixture was charged into a 500mL round bottom flask, At a temperature of 25° C., exposed to 365 nm ultraviolet light for reaction, the product (1,1,2,2-tetraphenylethylene glycol) was precipitated, and the precipitated product was purified by recrystallization from acetic acid.

[0036] obtained pure 1 H-NMR (CDCl 3 ): δ=3.05 (OH, 2H), 7.00-7.50 (phenyl, 20H).

[0037] Step 2): Mix polytetrahydrofuran ether diol (0.01mol; 10.00g) and 4,4'-diphenylmethane diisocyanate (0.02mol; 5.00g) into 50-100mL tetrahydrofuran, and the mixture is loaded into a 500mL In a three-necked round-bottomed flask, under nitrogen protection, stir and mix at 60-85°C for 1-4 hours to obtain a prepolymer; when the temperature drops to 20-45°C, add 1,1,2,2-tetraphenylethylene glycol ( 0.01mol; 3.66g), adding the molar ratio is: 1,1,2,2-tetraphenylethylene glyco...

Embodiment 2

[0042] Step 1): First mix benzophenone (0.1mol; 18.20g) and 2-propanol (0.5mol), then add glacial acetic acid (0.005mol; 0.03g), and the mixture is charged into a 500mL round bottom flask , at a temperature of 30° C., exposed to 365 nm ultraviolet light for reaction, the product (1,1,2,2-tetraphenylethylene glycol) was precipitated, and the precipitated product was purified by acetic acid recrystallization.

[0043] obtained pure 1 H-NMR (CDCl 3 ): δ=3.05 (OH, 2H), 7.00-7.50 (phenyl, 20H).

[0044] Step 2): Mix polycarbonate diol (0.01mol; 20.00g) and 4,4'-diphenylmethane diisocyanate (0.02mol; 5.00g) into 50-100mL butanone, and the mixture is charged to 500mL In a three-necked round-bottomed flask, under the protection of nitrogen, stir and mix at 60-85°C for 3 hours to obtain a prepolymer; when the temperature drops to 35°C, add 1,1,2,2-tetraphenylethylene glycol (0.01mol; 3.66g), the molar ratio of adding is: 1,1,2,2-tetraphenylethylene glycol: diisocyanate=0.3:1~1:2, an...

Embodiment 3

[0049] Step 1): First mix benzophenone (0.05mol; 9.10g) and isopropanol (0.25mol), then add 1mL of glacial acetic acid, and the mixture is charged into a 500mL round bottom flask, at a temperature of 25°C , exposed to 365nm ultraviolet light, the product (1,1,2,2-tetraphenylethylene glycol) was precipitated, and the precipitated product was purified by recrystallization from acetic acid.

[0050] obtained pure 1 H-NMR (CDCl 3 ): δ=3.05 (OH, 2H), 7.00-7.50 (phenyl, 20H).

[0051] Step 2): Mix polytetrahydrofuran ether diol (0.01mol; 10.00g) and 4,4'-diphenylmethane diisocyanate (0.02mol; 5.00g) and add 50-100mL N,N-dimethylacetamide , the mixture was put into a 500mL three-necked round-bottomed flask, stirred and mixed at 85°C for 1-4 hours under the protection of nitrogen to obtain a prepolymer; the temperature was lowered to 30°C, and 1,1,2,2-tetraphenyl Ethylene glycol (0.01mol; 3.66g), added in a molar ratio of: 1,1,2,2-tetraphenylethylene glycol: diisocyanate = 0.3:1 ~ ...

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Abstract

The invention relates anti-virus polyurethane material and a preparation method thereof, pertains to polymer material field. The material is polyurethane with monomer containing fluorin inserted into the main chain. The method uses materials including: benzophenone (I), isopropanol (II), polymeric diatomic alcohol (III), diisocyanate (IV), 2,2,3,4,4,4-Hexafluorobutyl acrylate (V) and vinylpyrrolidone;n-vinyl pyrrolidone (VI). The method including steps of: mixing material I and II, charging first catalyst, reacting under radiation of ultraviolet to obtain product of 1,1,2,2-tetraphenyl-1,2-ethanediol, recrystallizing and purifying by acetic acid, adding mixture of material III and IV into the solvent, stirring while reacting to obtain prepolymer; adding 1,1,2,2-tetraphenyl-1,2-ethanediol once more to get reactant, adding second catalyst, purifying to get polyurethane with 1,1,2,2-tetraphenyl-1,2-ethanediol, mixing it with material V and VI, and purifying to get fluorinated polyurethane. The invention has a long-term anti-virus effect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to a preparation method and application of a novel antibacterial polyurethane material. Background technique [0002] Polyurethane materials are widely used in long-term implanted medical devices and artificial organs, such as cardiac pacemakers, due to their excellent mechanical strength, high elasticity, wear resistance, lubricity, fatigue resistance, biocompatibility, and processability. Insulated wires, artificial blood vessels, interventional catheters, etc. Among the materials for long-term implantation in the body, there is still no material that has the same excellent comprehensive properties as polyurethane. However, the main problem of polyurethane as a biological material is that the currently used polyurethane material has no bactericidal function. Therefore, when it is implanted in the body, it is easily contaminated by bacteria, causing wound suppuration and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F120/22C08G18/65C08G18/83
Inventor 江贵长庹新林王晓工
Owner TSINGHUA UNIV
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