240results about How to "Inhibit enzyme activity" patented technology

The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like.A compound represented by the formula (I) or a salt thereof:wherein ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X1 and X2 are the same or different and each is C or N, the ring-constituting atoms X3 and X4 are the same or different and each is C, N, 0 or S (provided that a pyrrole ring wherein X1 is N is excluded from ring A), and when the ring-constituting atom X3 or X4 is C or N, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl, an acyl, an optionally substituted hydroxy, an optionally substituted mercapto, an optionally substituted amino, a halogen, a cyano and a nitro;R1 and R2 are each a cyclic group optionally having substituent(s); R3 and R4 are each H or alkyl, or R3 and R4 form, together with the adjacent N, an nitrogen-containing heterocycle; and Y is a spacer.

The present inventions relate to novel skin protectant creams and the use of such creams to cleanse, treat, and protect skin. The skin protectant creams can be topically applied to protect skin from irritants, to block the action of irritants such as enzymes, and to treat skin that has been subject to irritants. The creams can be applied manually or incorporated into disposable applicators, such as wipers or swabs. The skin protectant creams of the present invention are particularly useful in the prevention of severe skin breakdown which can lead to partial thickness skin wounds.

A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff in combination with a phytase expressed in yeast wherein the phytase can be selected from the group consisting of AppA1, AppA2 and a site-directed mutant of AppA. The invention also enables reduction of the feed to weight gain ratio and an increase bone mass and mineral content of an animal. A foodstuff and a feed additive comprising AppA2 or a site-directed mutant of AppA are also described.

The present invention provides 5-membered heterocycle compounds represented by the following general formula (I):The present compounds have a superior acid secretion inhibitory effect, and shows an antiulcer activity and the like.

The invention relates to a coating preservation method for eggs. The method comprises the following steps: (1) selecting fresh and crack-free eggs, cleaning the eggs and then adding water to soak the eggs; (2) taking 1 to 2 parts of xanthan gum, 1.6 to 2.05 parts of composite plant essential oil, 0.125 to 0.25 part of licorice flavonoids, 30 to 35 parts of an emulsifier and 50 to 100 parts of ganoderma lucidum polysaccharide, mixing the above-mentioned materials and adding the obtained mixture into water under stirring so as to obtain 1000 parts by weight of an essential oil emulsion; and (3) taking the essential oil emulsion and water according to weight parts, mixing the essential oil emulsion and water so as to obtain a spraying liquid, coating the shells of the eggs with the spraying liquid and drying the eggs at 37 DEG C in the air for preservation. According to the invention, the surface of each egg is coated by a layer of a preservative film which inhibits enzymatic activity of the eggs, alleviates decay of life, achieves the purpose of freshness and quality retention, increases the shelf life of the eggs and saves social cost; moreover, the coated preservative on the surfaces of the eggs is colorless and transparent after drying, so the advantages of safety and low cost are obtained.

The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing-N-acylamino compounds.

The invention provides a method to extract dihydroquercetin from roots of a particular tree species Larix olgensis. The method includes the steps of selection of raw materials, enzyme treatment, extraction, concentration, hydrolysis, extraction, recrystallization, and spray drying. Composition of the flavonoid compounds in the extractive of Larix olgensis is confirmed by HPLC-MS, and the extractive mainly comprises dihydroquercetin, and others compounds of aromadendrin, eriodictyol, quercetin and kaempferol. In vitro experiments prove that dihydroquercetin extractive form Larix olgensis has strong inhibitory effects on tyrosinase activity, and the effect of scavenging DPPH free radicals. Animal in vivo experiment demonstrates that the Larix olgensis extractive has good recovery effect on carbon tetrachloride induced liver injury.

The invention relates to a method used for preparing beet red color with high color value from dragon fruit, and belongs to the technical field of natural pigment. The method comprises following steps: a, dragon fruit is collected, ice blend is added, and an obtained mixture is subjected to pulp making and filtration so as to obtain juice; b, active carbon or diatomite is added into the obtained juice, and an obtained mixed material is stirred, centrifuged, and filtered so as to obtain a pigment solution; c, the obtained pigment solution is processed by using a MCI gel chromatographic column, is subjected to elution with water, and an eluent is collected and dried so as to obtain beet red color. Beneficial effects of the method are that: impurity content of the beet red color obtained via the method is low, color value is high, the method is simple and convenient, and production cost is low.

Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.

The invention relates to a method of extracting, purifying and inhibiting an alpha-glucosaccharase active ingredient from a chestnut shell. The method comprises the following steps: firstly, cleaning the chestnut shell, drying, crushing, refluxing and extracting by 75% (v / v) alcohol, concentrating under reduced pressure, adding water and statured n-butyl alcohol liquor to extract; and finally, carrying out adsorption elution by using macroporous resin AB-8 to obtain polyphenol extract with effect of inhibiting activity of alpha-glucosaccharase.

The invention discloses hippophae rhamnoides jam and a preparation method thereof. The method comprises the following steps of (1) preparing hippophae rhamnoides juice; (2) preparing hippophae rhamnoides pericarp paste; (3) preparing concentrated juice: mixing cucumber juice, apple juice and the hippophae rhamnoides juice at the mass ratio of 1:(2-3):(10-15), and freezing and concentrating until the weight percent of a soluble solid is 30-38%; (4) sterilizing: evenly mixing the separated pulp, pectin, fibers and the hippophae rhamnoides pericarp paste, then conducting pasteurization to obtain a pulp material, and conducting high voltage pulsed electric field sterilization on the concentrated juice to obtain sterile concentrated juice; and (5) taking the following raw materials by weight: 50-70 parts of the sterile concentrated juice, 5-15 parts of the pulp material, 1-5 parts of a stabilizer, and 10-25 parts of a sweetening agent, and mixing the raw materials evenly to obtain the hippophae rhamnoides jam. The hippophae rhamnoides jam prepared through the method is low in loss of nutrients and flavor substances, and is tasty and refreshing.