45results about How to "Inhibit gastric acid secretion" patented technology

A proton pump inhibitor containing a compound represented by the formula (I)wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

The present invention is related to oral compositions comprising an irreversible gastric H+ / K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and succinc acid as a parietal cell activator in the gastric lumen. The compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

A proton pump inhibitor containing a compound represented by the formula (I)wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I)wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

A Chinese medicine in the form of tablet or others for treating ulcer, gastritis, stomach-ache and abdominalgia is prepared from 8 Chinese-medicinal materials including cyperus tuber, corydalis tuber, liquorice root, scutellaria root, etc.

O-medium alkyl esters of diflunisal and related compounds are disclosed having anti-platelet activity, hydroxy radical scavenging properties, enhanced hepatic clearance and low ulcerogenic potential. These compounds have general formula (I) wherein n equals 3-13.

The invention discloses angelica keiskei tea which comprises 80-120 parts of angelica keiskei, 2-4 parts of fermented glutinous rice juice, 0.1-0.2 part of radix glycyrrhizae and an appropriate amount of saline water and brown sugar water, wherein the mass percent concentration of the saline water is 1.5-2.5%, and the mass percent concentration of the brown sugar water is 1.0-2.0%. The preparation method comprises a step (1) of picking fresh angelica keiskei leaves, cleaning and then draining the angelica keiskei leaves; a step (2) of soaking the angelica keiskei leaves in the saline water, fishing out the angelica keiskei leaves, and performing rinsing with clear water and draining; a step (3) of placing the angelica keiskei leaves in the brown sugar water to soak the angelica keiskei leaves, and then fishing out and draining the angelica keiskei leaves; a step (4) of preparing glycyrrhizae juice; a step (5) of taking and adding the fermented glutinous rice juice and the glycyrrhizae juice into the angelica keiskei leaves obtained in the step (3) to perform mixing, and then placing the angelica keiskei leaves in a tea manufacturing machine to perform preparation to obtain the angelica keiskei tea. The angelica keiskei tea is good in taste. The angelica keiskei tea has a certain health care effects of anticancer, antibiosis, anti-inflammation, pain relief, gastric acid secretion inhabitation, anti-ulcer, anti-thrombus, blood pressure reduction, blood sugar reduction, blood fat reduction and antianaphylaxis and the like.

The invention discloses a functional platycodon grandiflorum tea beverage and a preparation method thereof, relates to a functional tea beverage and a processing method thereof, and aims at solving the technical problems of high time consumption, low efficiency and low content of active ingredients of an existing making method of a platycodon grandiflorum beverage and a single function of the prepared beverage. The functional platycodon grandiflorum tea beverage disclosed by the invention comprises a mixed solution of platycodon grandiflorum clear juice and a scented tea extracting solution, white sugar, citric acid, malic acid, xanthan gum and sodium carboxymethylcellulose. The processing method comprises the following steps: 1, preparing the platycodon grandiflorum clear juice; 2, preparing the scented tea extracting solution; and 3, mixing and blending to obtain the functional platycodon grandiflorum tea beverage. The functional platycodon grandiflorum tea beverage disclosed by the invention is high in content of polysaccharides and flavonoid nutritional substances, is fragrant and sweet as well as cool and delicious, and is a health drink suitable for people of all ages.

The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and / or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

Provision of a compound having a superior proton pump action, which shows an antiulcer activity and the like after conversion to an in vivo proton pump inhibitor, a production method thereof and use thereof.A pyrrolo[2,3-c]pyridine compound represented by the formula:wherein each symbol is as defined in the specification.

The invention belongs to the pharmaceutical technical field and specifically relates to hydrosulphonyl benzoglioxaline derivatives which are shown in general formula (I) and contain dioxo heptane pyridine, isomers and pharmaceutically acceptable salts thereof, wherein, R<1>, R<2> and R<3> are defined as in the specification. The invention also relates to preparation methods of the compounds, drugcompositions containing the compounds and the application of the compounds in preparing drugs for preventing and / or treating digestive ulcer.

The invention belongs to the pharmaceutical technical field and specifically relates to benzoglioxaline derivatives which are shown in general formula (I) and contain naphthyridine tetrahydrofuran substituted by alcoxyl ethide, pharmaceutically acceptable salts and isomers thereof, wherein, R, R and R are defined as in the specification. The invention also relates to preparation methods of the compounds, drug compositions containing the compounds and the application of the compounds in preparing drugs for preventing and / or treating digestive ulcer.

The invention belongs to the pharmaceutical technical field and specifically relates to imidazopyridine derivatives which are shown in general formula (I) and contain dioxide heterocyclic pyridine, pharmaceutically acceptable salts and isomers thereof, wherein, R<1>, R<2>, R<3> and n are defined as in the specification. The invention also relates to preparation methods of the compounds, drug compositions containing the compounds and the application of the compounds in preparing drugs for preventing and / or treating digestive ulcer.

The invention discloses a functional platycodon grandiflorum tea beverage and a preparation method thereof, relates to a functional tea beverage and a processing method thereof, and aims at solving the technical problems of high time consumption, low efficiency and low content of active ingredients of an existing making method of a platycodon grandiflorum beverage and a single function of the prepared beverage. The functional platycodon grandiflorum tea beverage disclosed by the invention comprises a mixed solution of platycodon grandiflorum clear juice and a scented tea extracting solution, white sugar, citric acid, malic acid, xanthan gum and sodium carboxymethylcellulose. The processing method comprises the following steps: 1, preparing the platycodon grandiflorum clear juice; 2, preparing the scented tea extracting solution; and 3, mixing and blending to obtain the functional platycodon grandiflorum tea beverage. The functional platycodon grandiflorum tea beverage disclosed by the invention is high in content of polysaccharides and flavonoid nutritional substances, is fragrant and sweet as well as cool and delicious, and is a health drink suitable for people of all ages.