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A cervical support system for restricting head and neck movement of a patient recovering from an injury to or surgery on the spine. The support system includes a supporting member for mounting onto and around the head and neck of the patient. The supporting member includes an injection molded base portion integral with an occipital lobe supporting portion. The base portion is arranged to rest on the shoulder of the patient while the occipital lobe supporting portion is arranged to extend along the neck from the shoulder to the head of the patient. An arcuate member such as a C-collar is disposed on an outer surface of the supporting member. A plurality of adjustment devices such as a turn-tab adjustment mechanism on an outer surface of the arcuate member rotatably connect the arcuate member to the supporting member to position the arcuate member onto, and with respect to, the supporting member.

An interbody osteogenic fusion device is provided that includes opposite end pieces with an integral central element. The end pieces are sized to maintain the height of an intervertebral disc space. The central element has a much smaller diameter so that the osteogenic fusion device forms an annular pocket around the central element. An osteogenic material is disposed within the annular pocket between the opposite end pieces. In one embodiment, the osteogenic material constitutes a collagen sheet soaked in a solution containing a bone morphogenetic protein. The osteogenic fusion device is configured so that the osteogenic material is in direct contact with the adjacent vertebral bone. In addition to the enhanced area of contact between the vertebral bone and the fusion material, the inventive osteogenic fusion device reduces stress-shielding and minimizes the radiopacity of the implant so that growth of the fusion mass can be continuously assessed. In yet another embodiment, the osteogenic fusion device includes at least one end piece with a truncated surface. The osteogenic fusion devices of the present invention may be combined with other fusion devices to form an implant system. The implant system includes at least one load bearing member having a truncated surface configured to nest within another load bearing member, preferably the load bearing, osteogenic fusion device of the present invention. The invention also provides implant systems comprising adjacent load bearing members connected to one another to resist lateral separation. Methods of promoting fusion bone growth in the space between adjacent vertebrae utilizing devices and systems of the invention are also described.

This invention concerns compositions of tipifarnib, mannitol, and hydroxypropyl-β-cyclodextrin and, suitable for intravenous (IV) administration. The invention further concerns the use of such formulation and processes for preparing such formulations and methods of treating by administering said formulations.

The abdominal elevator comprises a body portion made from a flexible foam, a polymer, paper or fabric having at least one upper edge and, optionally, two or more side edges, with a shape ranging from triangular to rectangular to oval with one or more straps attached to one or more of the edges and also having an anterior surface and a posterior surface having a adhesive applied to the posterior surface. The straps of the abdominal elevator are attached to the bedrail using a secure method that comfortably elevates, retracts and retains the abdominal pannus during a surgical procedure that requires access to the lower abdomen and / or groin area that would otherwise be obstructed.