The present invention relates to the field of chemical treatment of metal surfaces, more specifically, the present invention relates to a copper-containing lamination etchant, an etching method and its application. The etchant includes a main agent, and in parts by weight, the main agent includes 1 ‑20 parts of oxidizing agent, 0.01‑1 part of fluoride ion source, 0.01‑5 part of inorganic acid, 1‑15 part of organic acid, 1‑15 part of organic base, 0.01‑5 part of hydrogen peroxide stabilizer, 0.01‑1 part of metal corrosion inhibitor , make up 100 parts of solvent. The etchant provided by the invention has low cost, no phosphorus, is environmentally friendly, and has low waste treatment cost; it can effectively suppress cracks at the interface of different metals; it has high copper ion loading capacity; it has excellent etching characteristics, unilateral CD‑Loss<0.9um, the etching angle (taper) is 35‑45°; it can solve the problem of chamfering, effectively avoid bubbles in the insulating layer, and avoid the step of pre-dissolving copper.