The invention discloses a health wine and a preparation method thereof, wherein the health wine comprises the following raw materials: bovine kidney, sheep kidney, penis et testis serpentis, cinnamon, polygonatum, raspberry, licorice, clove, cordyceps sinensis, yam, oyster, papaya, Chinese dates, wolfberry fruit, arillus longan, honey, crystal sugar and 30-degree Daqu spirit. The preparation method is as follows: cleaning the bovine kidney, sheep kidney, penis et testis serpentis, cinnamon, polygonatum, raspberry, licorice, clove, cordyceps sinensis, yam, oyster, papaya, Chinese dates, wolfberry fruit and arillus longan, adding water for leaching, filtering to separate filtrate liquor from filter residue, then repeatedly leaching twice, mixing filtrates obtained at the three times, heating and concentrating to obtain extract, mixing the extract, refined honey, refined crystal sugar and 30-degree Daqu spirit and evenly stirring, sealing and standing for one month, then taking out, filtering to remove impurities, and finally filling to obtain the finished product. The health wine has the efficacies of invigorating premodial energy, tonifying kidney yang, enriching essence and blood,supplementing blood, nourishing yin, and nourishing blood to tranquillize mind.