55results about How to "Capacity retention" patented technology

This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.

This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.

The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA.

Nanowire array compositions in which nanowires containing at least one Group IV metal (e.g., Si or Ge) in a single layer or core-shell nanowire structure, wherein, in particular embodiments, the nanowires have a transition metal core and / or are surrounded by or embedded within a metal oxide or metal oxide-ionic liquid ordered host material. The nanowire compositions are incorporated into the anodes of lithium ion batteries. Methods of preparing the nanowire compositions, particularly by low temperature methods, are also described.

A point chisel for use with a power tool includes an elongate stem (1) having, at its power tool side a shank (2) for securing the chisel in the power tool and, at its workpiece side, a useful region (3) having its outer diameter (H) tapering toward its workpiece end and having a cross-section (5) formed as a concave polygon by a plurality of axial grooves (4) extending radially toward a core diameter (K) that likewise tapers toward the workpiece side end of the useful region (3).

A three-dimensional cellular textile composite structure with energy-absorbing capacities under multiple impacts is provided. The cellular textile composite structure includes a base, and at least one progressively collapsible projection extending from the base for absorbing energies under the multiple impacts. The projection includes a non-woven textile material supported in a thermoplastic matrix material such that the projection is capable of retaining energy-absorption capacity at least after the first impact of the multiple impacts.

The invention provides novel lithium-mixed metal materials which, upon electrochemical interaction, release lithium ions, and are capable of reversibly cycling lithium ions. The invention provides a rechargeable lithium battery which comprises an electrode formed from the novel lithium-mixed metal materials. Methods for making the novel lithium-mixed metal materials and methods for using such lithium-mixed metal materials in electrochemical cells are also provided. The lithium-mixed metal materials comprise lithium and at least one other metal besides lithium. Preferred materials are lithium-mixed metal phosphates which contain lithium and two other metals besides lithium.

Provided herein are biomolecular hybridization devices comprising a substrate with a permanently and covalently attached surface of functional groups and an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide. The constrained oligonucleotides are effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing and without oligonucleotide dissociation from the surface of the device. Also, provided are methods for hybridizing solution-state target nucleic acids to probe nucleic acids and for identifying a nucleotide sequence to which a nucleotide-binding protein binds using the biomolecular hybridization devices.

The present invention provides antibodies against glycosylated proBNP and NT-proBNP. The antibodies are suitable for precise immunodetection of both of the proteins in human blood. The glycosylated forms of proBNP and NT-proBNP may be utilized as an antigen for antibody generation as well as a calibrator or immunological standard in different types of immunoassays. The invention thus also relates to a stable standard or calibrator pro-Brain Natriuretic Peptide (proBNP) preparation for use in a method for detecting BNP immunoreactivity in a sample, the preparation comprising glycosylated proBNP or a fragment thereof. In addition, the present invention is directed to an assay for precisely detecting the NT-proBNP circulating in a patient's blood, wherein the level of glycosylation of the proBNP molecule is exploited. Therapeutic applications are also contemplated.

The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of making monoclonal antibodies.

The invention provides new and novel lithium-metal-fluorophosphates which, upon electrochemical interaction, release lithium ions, and are capable of reversibly cycling lithium ions. The invention provides a rechargeable lithium battery which comprises an electrode formed from the novel lithium-metal-fluorophosphates. The lithium-metal-fluorophosphates comprise lithium and at least one other metal besides lithium.

A method for discharging countermeasures, a rocket launcher, and a dispenser arrangement. A space for one or more rockets in a rocket launcher is used as a carrier for a dispenser arrangement for countermeasures. The dispenser arrangement is designed with one or more cylindrical sections specially adapted to the rocket space in the rocket launcher. Equipment already adapted to aircraft can be used in supplementing the countermeasure equipment of the aircraft.

The invention discloses a multi-protocol compatible method of sharing double stream audios in a conference, an apparatus and a system. One method is applied to a first terminal supporting a SIP protocol and an H.323 protocol and comprises the following steps of using the SIP protocol to call a second terminal; according to a first response message returned by the second terminal, determining whether connection is successful; when the connection is determined to be unsuccessful based on the first response message, using the H.323 protocol to call the second terminal; according to a second response message returned by the second terminal, determining whether the connection is successful; when the connection is determined to be successful based on the second response message, establishing a conference with the second terminal through the H.323 protocol, carrying out audio mixing on a single channel or multiple channels of mainstream audios and auxiliary stream audios and sending the audios after audio mixing to the second terminal through a mainstream channel. By using the method, the apparatus and the system of the invention, the double stream audios can be effectively shared in a video conference system of SIP and H.323 double protocols.

An electromagnetic actuator has a rotor and a stator around which coils are wound to face portions of an outer surface of the rotor. The stator is C-shaped, the rotor is arranged so that a rotation axis thereof is existent in a space surrounded by the stator, and both ends of the stator are respectively formed within a range from 15 to 90 degrees from a virtual base line with respect to the rotation axis serving as a center, when the virtual base line is set to run a center of the rotation axis and separate the stator into left and right.

The invention provides new and novel lithium-metal-fluorophosphates which, upon electrochemical interaction, release lithium ions, and are capable of reversibly cycling lithium ions. The invention provides a rechargeable lithium battery which comprises an electrode formed from the novel lithium-metal-fluorophosphates. The lithium-metal-fluorophosphates comprise lithium and at least one other metal besides lithium.

A bipolar overvoltage battery pulser and method are provided that apply a positive pulse voltage and a negative pulse voltage alternately across the terminals of a battery. The object of the bipolar overvoltage battery pulser and method is to increase the cycle lifetime and capacity of storage batteries, such as lead acid batteries. The rise times for the leading edges of the positive pulses and for the trailing edges of the negative pulses are short compared to the ionic relaxation time in the electrochemical solution. Alternating between the positive and negative pulses gives each new pulse an equal starting condition without realizing any memory effect that otherwise may result if the last applied pulse was of the same polarity, which reduces the extent of overvoltage that may be applied to the battery and decrease the highest useable pulse cycling frequencies that could be achieved without experiencing pulse overlapping. The shape, type and timing of the pulses may be adjusted to create overvoltage pulses having high duration and amplitude.

A non-aqueous electrolyte solution for lithium or a lithium ion cell, which improves lithium ion cell capacity retention and enhances storage life thereof. The non-aqueous solution can be implemented in the context of an electrolyte system that includes a lithium salt dissolved in a solvent formed from a mixture of one or more cyclic esters, and / or one or more chain esters, and at least one lactam based solvent. Such a system is suited for use with electrochemical energy storage devices, which are based on non-aqueous electrolytes, such as high energy density batteries and / or high power electrochemical capacitors. Such an electrochemical storage devices is generally based on non-aqueous electrolytes that include lithium salt dissolved in a solvent system.

The present invention is a multipurpose machete assembly comprising of a no tool removable handle / scales, a ferrocium rod or bottle with cap holder or mount and a multi-purpose blade. The blade has a spur knife for precision work, a gut hook, a spear point / digging point, a recessed area for holding dirt, a cooking pan, a special toothed high efficiency saw, a hook / gaff, a forward lanyard hole, a hammer / pommel / knob, a flat area for scrapping, a long strait or flat section for using as a draw knife, and holes through blade for processing cordage.

An electromagnetic actuator has a rotor and a stator around which coils are wound to face portions of an outer surface of the rotor. The stator is C-shaped, the rotor is arranged so that a rotation axis thereof is existent in a space surrounded by the stator, and both ends of the stator are respectively formed within a range from 15 to 90 degrees from a virtual base line with respect to the rotation axis serving as a center, when the virtual base line is set to run a center of the rotation axis and separate the stator into left and right.

The invention provides new and novel lithium-metal-fluorophosphates which, upon electrochemical interaction, release lithium ions, and are capable of reversibly cycling lithium ions. The invention provides a rechargeable lithium battery which comprises an electrode formed from the novel lithium-metal-fluorophosphates. The lithium-metal-fluorophosphates comprise lithium and at least one other metal besides lithium.

Electrodes for rechargeable batteries that include silicon and a binder are provided. Binders for use with silicon electrodes are provided, including polysiloxane binders that can be prepared prior to preparation of the electrode, or provided as monomers to be cure-polymerized at the time of the curing of the electrode.

Method intended for real-time modelling, by neural networks, of hydrodynamic characteristics of multiphase flows in transient phase in pipes. In order to specifically take account of the possible flow regimes of fluids in pipes, various neural or “expert” models are formed for several flow regimes (or subregimes) in the whole of the variation range of the hydrodynamic characteristics of the flows (preferably for each one of them), as well as a neural model estimating the probability of belonging of the flows to each flow regime or subregime, knowing some of the characteristics thereof. The probabilities obtained are used for weighting the estimations delivered by each neural model, the result of the weighted sum being then the estimation eventually retained. Applications to various industries and notably for modelling of hydrocarbon flows in pipelines.

A garment protector suitable for covering the head while trying on wearing apparel to prevent staining or soiling of the wearing apparel from dirt, facial oils, makeup, or the like, wherein the garment protector is comprised of two sheets of tissue paper substantially secured together about their periphery, leaving an opening for insertion of the wearer's head therethrough. Tabs extend downward from the open portion of the periphery, wherein the tabs are removably insertable in the wearer's clothing / undergarments to secure the garment protector in place prior to trying on the wearing apparel.

The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumor cell preparation (ATCP). The invention also provides an activated NK cell produced by such a method and its use in the treatment of cancer.

The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of making monoclonal antibodies.

The invention relates to lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate, the use of lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate as electrolyte salt in lithium-based energy stores and also ionic liquids comprising 1-trifluoro-methoxy-1,2,2,2-tetrafluoro-ethanesulphonate as anion.

Methods of pretreating an electroactive material comprising lithium titanate oxide (LTO) include contacting a surface of the electroactive material with a pretreatment composition. In one variation, the pretreatment composition includes a salt of lithium fluoride salt selected from the group consisting of: lithium hexafluorophosphate (LiPF6), lithium tetrafluoroborate (LiBF4), and combinations thereof, and a solvent. In another variation, the pretreatment composition includes an organophosphorus compound. In this manner, a protective surface coating forms on the surface of the electroactive material. The protective surface coating comprises fluorine, oxygen, phosphorus or boron, as well as optional elements such as carbon, hydrogen, and listed metals, and combinations thereof.

Provided is a lithium ion capacitor that can retain a capacity under a high temperature environment and has small increase in internal resistance while using an aqueous binder for a positive electrode. A lithium ion capacitor includes: a positive electrode; a negative electrode; and an electrolytic solution contacting the positive electrode and the negative electrode. The electrolytic solution includes an organic solvent and a lithium salt electrolyte having an imide structure; the positive electrode includes a collector foil and a positive electrode active material; and the positive electrode active material is held onto the collector foil through a binder including a polymer having a RED value to the electrolytic solution of more than 1, the RED value representing a relative energy difference with respect to the electrolytic solution based on Hansen solubility parameters.

A data file reproduction system has a data file supplying apparatus that extracts video data and audio data from a received data file, compresses the extracted video and audio data and produces a compressed data file containing the compressed audio and video data together with meta data or navigation data determined from the received data file for enabling navigation of the original data file. The compressed data file is then copy-protected. Upon request, the copy-protected compressed data file is communicated to a reproduction apparatus. The reproduction apparatus decompresses the compressed audio and video data of the received copy-protected compressed data file, encodes the decompressed audio and video data and produces a copy-protected reconstituted data file containing the encoded audio and video data together with the meta or navigation data determined from the copy-protected compressed data file, so enabling navigation of the copy-protected reconstituted data file in the same manner as the original data file.