38 results about "Topical microbicides" patented technology

An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component with a chamber containing a first cleaning agent. A second component includes a second cleaning agent. A third component has a microbiocidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent, the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port.

The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.

The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.

Fecal bacterial contamination in an animal is reduced by providing it with drinking water containing a microbiocidally-effective amount of halogen-based microbiocide resulting from mixing with water (A) a product formed in water from (i) bromine, chlorine, or bromine chloride, or any two or more thereof, (ii) a water-soluble source of sulfamate anion, and (iii) a water-soluble base; (B) at least one 1,3-dihalo-5,5-dialkylhydantoin in which one of the halogen atoms is a chlorine atom and the other is a chlorine or bromine atom, and in which each alkyl group, independently, contains in the range of 1 to about 4 carbon atoms; (C) at least one 1,3-dibromo-5,5-dialkylhydantoin in which one of the alkyl groups is a methyl group and the other alkyl group contains in the range of 1 to about 4 carbon atoms; or (D) any two or more of (A), (B), and (C).

Microbicidal compositions including (a) cyanodithiocarbimate and (b) an N-alkyl heterocyclic compound; a triazole compound or salt thereof or metal complex thereof; a microbicide with an activated halogen atom or a formaldehyde releasing compound; 1,4-bis(bromoacetoxy)-2-butene; 2-(thiocyanomethylthio)benzothiazole; a methylene-bis(thiocyanate); a halogenated acetophenone; a halopropynl compound; an iodosulfone; a phenol; a halocyanoacetamide compound and / or a quaternary ammonium compound are described. Components (a) and (b) can be present in a synergistically effective amount to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms with the compositions are also disclosed.

The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV / AIDS.

Fecal bacterial contamination in an animal is reduced by providing it with drinking water containing a microbiocidally-effective amount of halogen-based microbiocide resulting from mixing with water (A) a product formed in water from (i) bromine, chlorine, or bromine chloride, or any two or more thereof, (ii) a water-soluble source of sulfamate anion, and (iii) a water-soluble base; (B) at least one 1,3-dihalo-5,5-dialkylhydantoin in which one of the halogen atoms is a chlorine atom and the other is a chlorine or bromine atom, and in which each alkyl group, independently, contains in the range of 1 to about 4 carbon atoms; (C) at least one 1,3-dibromo-5,5-dialkylhydantoin in which one of the alkyl groups is a methyl group and the other alkyl group contains in the range of 1 to about 4 carbon atoms; or (D) any two or more of (A), (B), and (C).

The present disclosure relates to compositions and methods for contraception that also enhance the efficacy of microbicides. Such compositions serve the dual purpose of preventing pregnancy and lessening the risk of spreading sexually transmitted diseases. More specifically, the compositions and methods relate to syngergistic contraceptive microbicide and antiviral compositions comprising a combination of a contraceptive microbicide and an antiviral agent in an acidic carrier that enhances the efficacy of both the contraceptive microbicide and antiviral agent.

Antimicrobial compositions based on haloalkynyl active ingredients that are chemically stable in the presence of chelated metal ion are disclosed. Particularly preferred is the use of metal ion chelating agents based on selected amine compounds that provide the metal ion in a form sufficient to provide stability to other antimicrobial components in the aqueous composition, but without concurrently degrading the antimicrobial effectiveness of the haloalkynyl active ingredient.

The invention provides a novel microbicide anhydride modified anti-SEVI (semen-derived enhancer of viral infection) polyclonal antibody for preventing HIV (human immunodeficiency virus) sexual transmission. The novel microbicide anhydride modified anti-SEVI polyclonal antibody comprises an anti-SEVI polyclonal antibody, wherein the anti-SEVI polyclonal antibody can be used for immunizing rabbit or other tested animals by a conventional method by synthesizing a polypeptide fragment PAP248-286 of SEVI, antiserum of anti-SEVI is collected, and IgG (immunoglobulin G) of the antibody is purified to obtain the polyclonal antibody. The anhydride modified anti-SEVI polyclonal antibody is obtained by performing anhydride modification on the antibody. The anhydride modified anti-SEVI polyclonal antibody has excellent anti-virus activity to HIV-1 pseudovirion strain, zoo virus strain and anti-HIV medicinal HIV-1 drug-resistance strain, and the anhydride modified anti-SEVI polyclonal antibody can specifically bind SEVI, so that the reinforcing effect of the SEVI in seminal fluid to HIV infection can be blocked. The antibody has the beneficial effects that a dual-functional HIV sexual transmission preventing candidate microbicide can be used for resisting the strengthening capability of SEVI to HIV infection and has high-effective HIV activity.

Poultry carcasses are contacted with water treated with one or more specified dihalodialkylhydantoin biocides in a processing operation downstream from a scalding tank. The aqueous effluent from that downstream operation or from any location further downstream is recycled to the scalding tank. Surprisingly, the bromine residues from the dihalodialkylhydantoin biocides are much more thermally unstable than, for example, the commonly used microbiocide, sodium hypochlorite. Thus, the effluent from the scalding tank has its active bromine content significantly reduced before it is sent to a water purification facility wherein microbial action is used to reduce the BOD of the waste water before its release to the environment. Thus, injury to this desired microbial action is reduced. In addition, the recycle reduces water consumption in the overall poultry processing operation.

A multifunctional polyethylene glycol-based hydrogel that includes a multi-arm polyethylene glycol cross-linking unit covalently bound to at least four multi-arm polyethylene glycol nanocarrier units, wherein each nanocarrier unit includes an agent coupled to the nanocarrier unit and each agent is selected from pH-lowering agents, bioadhesion agents, microbicidal-spermicidal agents, and agents that inhibit free and cell-associated HIV binding, provided that each nanocarrier unit comprises a different agent.

The invention discloses an anti-HIV JB protein rectum gel preparation and a preparation method thereof. Potent microbicide JB protein is used as the main active ingredient of the rectum gel preparation which is mainly used for preventing AIDS pathophoresis. The optimized rectum gel preparation comprises, by mass concentration, 0.1-5% of JB protein, 0.1-10% of Carbomer, 0.5-10% of propylene glycol, 5-15% of glycerinum, 0.1-3% of hydroxyethyl cellulose, 0.1-1% of methylparaben and 0.1-1% of propylparaben and the balance water. The anti-HIV JB protein rectum gel preparation can be used for preventing AIDS pathophoresis and has the wide market prospect and high application value.

This invention is related to a pneumatic mechanical milking system (1) for a dairy animal that allows reducing, inhibiting, and / or preventing infection by mastitis, with fungicide, anti-bacteria, anti-virus, and microbicide surface properties, wherein the system comprises at least one device (2) that connects the animal udder (3), that defines a cylindrical shape (4), where the said device defines different openings at its corresponding ends, an upper opening (5) of a larger diameter through which end the dairy animal udder is introduced, a lower end (6) with a smaller diameter, comparable to the upper end through which milk is extracted, and a lower angular end (7) of small diameter, formed by an expanded tubular section (8) connecting the system air supply, wherein said device (2) entire surface has a rugosity quality within a specific range and it is formed by a special alloy containing at least 50% copper; at least one extended membrane (9) in the sense of its main axis, with an upper end (10) with a lip (11) that externally fits into the device (2) upper opening (5), and a lower end (12) that goes through the device lower end (6) opening; a milk collector (13) that includes a cover (14) provided with at least four entries (15, 16, 17, 18), where at least one of the said entries connects with the expanded membrane lower end (12), wherein said cover also includes at least four air intakes (19, 20, 21, 22); the said collector and cover entire surface have a surface rugosity quality within a specific range, and the said surface is formed by a special alloy with at least 50% copper content; and at least one longitudinal connector (23) to channel air which, at the one end (24) connects the device (2) extended tubular section (8) and, on the other end (25), it connects a collector (13) air intake. The invention also includes a procedure to implement the said pneumatic mechanical system to milk a dairy animal, as well as the use of the said mechanical system and device in traditional and / or organic dairy plants.

A synergistic microbicidal composition containing: (a) at least one microbicide selected from the group consisting of isopropyl methyl phenols and monosubstituted phenols and (b) at least antimicrobial alcohol is selected from the class consisting of acyclic terpene alcohols.

The invention discloses application and salvianolic acid B and analogues of the salvianolic acid B in preparing anti-HPV-viral-infection medicine, and belongs to the field of biomedicine. The inventordiscovers that the salvianolic acid B and the analogues, such as myricetin and dihydromyricetin, of the salvianolic acid B for the first time through researches, the salvianolic acid b and the analogues of the salvianolic acid B have good anti-HPV-viral-infection activity and can effectively block adhering of HPV viruses to target cells, and then HPV viral infection is inhibited. Experiments prove that the salvianolic acid B and capsid protein of the viruses can be directly bound, and adhesion of antagonism viruses to the target cells achieves an anti-virus effect. The salvianolic acid B actsin the early stage that the viruses enter the cells, and can also act in the middle stage and the later stage that the viruses enter the cells. The effects are better than medicine only acting on theearly stage that the viruses enter the cells in the prior art. The salvianolic acid B is harmless to the human body in a concentration range where the salvianolic acid B can achieve the anti-virus function. It is very likely that the salvianolic acid B is developed into a novel microbicide for preventing and treating HPV and other sexually transmitted viral infection.

Use of poly(4-styrene sulfonic acid-copoly-maleic acid) sodium salt in the preparation of pharmaceutical inhibiting infection of HIV-1 and pharmaceutical composition thereof. Said pharmaceutical composition comprises poly(4-styrene sulfonic acid-copoly-maleic acid) sodium salt as active ingredient and conventional pharmaceutical carrier.

A port cap has a closed end, an open end, and a conical body made of a flexible material. An inside of the port cap may have a textured or uneven surface. The textured or uneven surface may be formed by one or more annular rings. An annular ring may be asymmetrical having different slopes on the two different sides of the annular ring. The port cap may be made of an elastomeric polymer or elastomeric copolymer. An insert inside the port cap may be made of a sponge or similar material and may contain a cleaning agent or microbiocidal. The port cap may be sealed with a lid. Methods of using the port cap are also disclosed.

The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted / founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.

The present invention relates to a method for reducing or preventing the formation or activity of a corrosion-associated biofilm on a metal surface, wherein the method comprises contacting the metal surface with a liquid composition comprising biocidal preparation. The present invention also relates to a microbicidal composition comprising at least one alcohol, one liquid hydrocarbon, a bacteriophage immobilized on a magnetic nanocomposite, at least one phage releasing reagent and one stabilizer. The microbicide composition and method of the present invention reduces biofilms on surfaces, and consequently, reduces, mitigates, or eliminates MIC in internal surface of the oil transporting pipelines.

The invention discloses medicinal use of (3,4-dihydroxyl-5-nitrophenyl)-(4-methylphenyl)ketone. Discovered through researches by the inventor, the (3,4-dihydroxyl-5-nitrophenyl)-(4-methylphenyl)ketoneeffectively inhibits semen amyloid fibers from forming, breaks forms of the semen amyloid fibers and inhibits the semen amyloid fibers from being bonded to viruses, thus, the action that the semen amyloid fibers promote sexual propagation of virus HIV-1, virus Ebola and the like is blocked, and the (3,4-dihydroxyl-5-nitrophenyl)-(4-methylphenyl)ketone is an ideal microbicide.

The invention discloses a novel application of myricetin and derivatives thereof and an anti-HIV infection microbicide. The myricetin can inhibit formation of SEVI, destroy a mature SEVI structure and directly block off HIV infection enhancement caused by the SEVI; and in addition, the myricetin, which also has a good anti-HIV activity, can be developed into the dual-function microbicide capable of antagonizing the SEVI and resisting HIV, so as to prevent possibility that a poor clinical curative effect is caused due to existence of amyloid fibers in seminal fluid to the greatest extent; with the presence of the seminal fluid, the myricetin can coordinate with any one anti-retroviral agent, which is selected from azidothymidine, raltegravir, maraviroc, tenofovir, nevirapine and efavirenz, so as to resist the HIV; the multi-component anti-HIV infection microbicide, which contains the myricetin and the anti-retroviral agent, can be developed; and the microbicide can simultaneously act on two aspects, namely the seminal fluid and viruses, so that a better anti-HIV infection clinical curative effect can be developed.

The present invention relates to an antimicrobial composition comprising at least one source of water-soluble or water-dispersible zinc ions in combination with at least one source of water-soluble or water-dispersible lithium ions and optionally at least one source of water-soluble or water-dispersible magnesium ions and / or at least one source of water-soluble or water-dispersible sodium ions, the invention also relates to an aqueous formulation, a method of preserving an aqueous formulation against microorganisms and the use of an antimicrobial composition for preserving an aqueous formulation against microorganisms.

A liquid antimicrobial composition is provided for use in disinfecting the skin of a human or animal, in particular when a drug tolerant organism is required to be disinfected. The composition comprises a cationic microbicide that disrupts a cell membrane and a cationic branched polymer capable of inhibiting the efflux pump mechanism of the cell membrane. The cell membrane disrupting cationic microbicide is preferably any one or a combination of chlorhexidine, polymeric biguanide, octenidine dihydrochloride, and a quaternary ammonium compound. The branched polymers provided are capable of binding and disrupting cell membranes of microorganisms, inhibiting or disrupting efflux pump mechanisms of cells, thereby preventing microbial strains from producing tolerance to increasingly prevalent cell membrane disrupting cationic microbicides, especially when the microbicides comprise chlorhexidine. The branched polymer is preferably any one of, or a combination thereof, a 0-to 3-generation branched polymer comprising a poly (propylene imine) functionalized quaternary ammonium, a polylysine, a branched polymer having a sugar-based surface group, and a polyamidoamine (PAMAM) branched polymer. The composition is preferably in the form of an aqueous or hydroalcoholic solution, dispersion or emulsion that can be adsorbed by the wipe.

This invention provides a method of controlling microbes in a drinking line system when poultry and / or swine are absent from the area where the drinking line system is located. The method comprises I) contacting the drinking line system and an aqueous microbiocidal solution; and II) flushing said drinking line system with water and / or an aqueous solution comprising one or more scale removers at least once after said contacting with said aqueous microbiocidal solution, wherein said aqueous microbiocidal solution is formed from components comprising water and a concentrated aqueous biocidal solution selected from A) an aqueous biocide solution having an active bromine content of about 50,000 ppm or more, which solution is formed from components comprising water and (i) bromine chloride or bromine chloride and bromine, with or without conjoint use of chlorine, and (ii) overbased alkali metal salt of sulfamic acid and / or sulfamic acid, alkali metal base, and water, wherein the relative proportions of (i) and (ii) are such that the atom ratio of nitrogen to active bromine is greater than 0.93, and wherein the pH of the composition is greater than 7, or B) an aqueous biocide solution formed from components comprising water and (i) at least one bromide source selected from ammonium bromide, hydrogen bromide, at least one alkali metal bromide, at least one alkaline earth metal bromide, and mixtures of any two or more of the foregoing, (ii) a chlorine source, optionally (iii) at least one inorganic base, and optionally (iv) sulfamic acid and / or a metal salt of sulfamic acid, or C) a combination of A) and B). Any degradation of the materials of the drinking line system from contact with said aqueous microbiocidal solution is minimal.

Provided is a microbicide-containing aqueous composition having a superior effect of stabilizing 5-chloro-2-methyl-4-isothiazolin-3-one. This microbicide composition includes: (A) 5-chloro-2-methyl-4-isothiazolin-3-one; (B) 2,2,6,6-tetramethylpiperidin-1-oxyl; and (C) at least one solvent selected from the group consisting of water and a hydrophilic organic solvent.