The invention provides a preparation for rapid treatment of fatty liver. The preparation is prepared from the following herbal raw materials: Abrus cantoniensis, Semen Sinapis, Allium macrostemon, filiform cassytha herb, Elsholtzia blanda, Asparagus cochinchinensis, radix angelicae pubescentis, Phyllanthus urinaria, Hedyotis diffusa, scutellaria baicalensis, ginger, Elsholtzia ciliata, Fritillaria thunbergii, Polygala japonica, seaweed, Chinese Buckeye Seed, chicken's gizzard-membrane, Amomum kravanh, Poncirus trifoliate, Cortex Lycii, Curcuma zedoaria, ruddle, dragon bone, and Swertia bimaculata. The preparation for rapid treatment of fatty liver provided by the invention selects medicinal materials with appropriate compatibility, is accord with the theories of traditional Chinese medicine and pharmacy and modern medicine and pharmacology, all the medicinal materials are compatible, and can jointly achieve the efficacy of lowering lipid and benefiting liver, tonifying Yin and dispersing blood stasis, nourishing yin for lowering fire, activating stagnancy and dredging vessels. With significant curative effect on fatty liver, the preparation provided by the invention has the advantages of safety and reliability, quick effect, convenient oral administration, no toxic or side effect and no recurrence after cure, can achieve the purpose of treating both symptoms and root causes, effectively eliminates or alleviates infiltration of fat in liver, protects the liver function, reduces blood lipid, and is worthy of wide promotion and application in clinical practice.