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Process for purifying tetrahydronaphthalene swertia bimaculata noline

A technology of Swertia nolin and Swertia, which is applied in the field of medicine, can solve the problems of tetrahydroswertia nolin, etc., and achieve the effect of simple steps, no energy consumption, and large enrichment amount

Inactive Publication Date: 2014-10-01
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no relevant report on the industrial separation and preparation method of tetrahydroswertia norin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Crush Swertia japonica to 20 mesh, take 5kg and put it into a microwave extraction tank, add 60L of 35% ethanol solution for microwave extraction for 1 hour, microwave extraction power is 10kW, extract 3 times, combine the extracts, recover ethanol under reduced pressure until it is in the form of an extract, add water to dissolve , filter out the insoluble matter, add the filtrate to a 5L D101 macroporous resin column for adsorption, wash it with water until the sugar reaction is negative, then use 20L of 60% ethanol solution to elute the active ingredient, collect the eluate, add the eluate to a hollow compound with a molecular weight cut-off of 3000 Membrane ultrafiltration Membrane ultrafiltration, the permeate is added to the hollow composite nanofiltration membrane with a molecular weight cut-off of 100 to concentrate, the inlet pressure is controlled to 0.8MPa to obtain a concentrated solution, and the concentrated solution is dried to obtain a crude product, using...

Embodiment 2

[0025] Crush Japanese Swertia to 60 mesh, take 5kg and put it into a microwave extraction tank, add 60L of 35% ethanol solution for microwave extraction for 1 hour, microwave extraction power is 1kW, extract once, combine the extracts, recover ethanol under reduced pressure until it is in the form of an extract, add water to dissolve , filter out the insoluble matter, add the filtrate to 5L AB-8 macroporous resin column for adsorption, wash it with water until the sugar reaction is negative, then use 35L55% ethanol solution to elute the active ingredient, collect the eluent, add the eluent to the Hollow composite membrane ultrafiltration membrane ultrafiltration, the permeate is added to the hollow composite nanofiltration membrane with a molecular weight cut-off of 100 to concentrate, the inlet pressure is controlled to 0.5MPa to obtain a concentrated solution, and the concentrated solution is dried to obtain a crude product, which is 5 times the weight of the crude product (V / ...

Embodiment 3

[0027] Swertia japonica was crushed to 80 mesh, 5 kg was put into a microwave extraction tank, and 60L of 35% ethanol solution was added for microwave extraction for 2 hours. The microwave extraction power was 5kW, and the extraction was performed 3 times. The combined extracts were decompressed and the ethanol was recovered until it was in the form of an extract and dissolved in water. Filter out the insoluble matter, add the filtrate to a 5L SPD100 macroporous resin column for adsorption, wash it with water until the sugar reaction is negative, then use 28L of 70% ethanol solution to elute the active ingredient, collect the eluate, and add the eluate to a hollow composite membrane with a molecular weight cut-off of 6000 Ultrafiltration membrane ultrafiltration, the permeate is added to the hollow composite nanofiltration membrane with a molecular weight cut-off of 100 to concentrate, the inlet pressure is controlled to 0.6MPa to obtain a concentrated solution, and the concentr...

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PUM

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Abstract

The invention discloses a process for purifying tetrahydronaphthalene swertia bimaculata noline. The method comprises the following steps: by taking Japanese noline as a raw material, adding an ethanol solution, carrying out microwave extraction, and recovering ethanol from an extracting solution; adding hot water to dissolve extractum, adding a polar macroporous resin column to absorb and elute, and carrying out ultrafiltration on an eluent by an ultrafiltration membrane; concentrating the eluent by a nanofiltration membrane, drying to obtain a crude product, dissolving by hot water, placing and participating, and filtering to obtain the tetrahydronaphthalene swertia bimaculata noline. The method disclosed by the invention has the advancement and practical value that the tetrahydronaphthalene swertia bimaculata noline prepared by using the method is high in purity, simple and practical in method, and easy to industrialize.

Description

technical field [0001] The invention relates to a purification process of tetrahydro-swertia norin, which belongs to the field of medicine. Background technique [0002] Tetrahydroswertianolin is a phenolic compound with the molecular formula C 20 h 24 o 11 , the molecular weight is 440.4, and the structural formula is: [0003] [0004] Tetrahydroswertia norin is derived from the whole plant of Japanese Swertia japonica Makino in the family Gentianaceae. Modern pharmacological studies have shown that tetrahydroswertia nolin has hepatoprotective effect on immune-induced liver damage in mice, and its effect is stronger than that of glycyrrhizic acid. [0005] At present, there is no relevant report on the industrial separation and preparation method of tetrahydroswertia norin. Contents of the invention [0006] The object of the present invention is to provide a simple and high-yield purification process for tetrahydroswertina norin. [0007] The present invention ...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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