The invention discloses a
bacterial polysaccharide protein conjugate vaccine using a
hepatitis B surface
antigen as
carrier protein and a preparation method of the
bacterial polysaccharide protein conjugate vaccine. According to the vaccine,
protein is the
hepatitis B surface
antigen, and a
bacterial polysaccharide is selected from any one or more of a
haemophilus influenza type b
polysaccharide, group A, group C, group Y and group W135 meningococcal polysaccharides, a
salmonella typhi type Vi
polysaccharide, a group B
streptococcus type Ia
polysaccharide and the like, pneumococcus
serotype type 1, 2 and the like, and
salmonella paratyphi type A or
salmonella paratyphi type B. Animal experiments show that the
antibody positive conversion rates of the bacterial polysaccharide and the
hepatitis B surface
antigen in the vaccine are both more than 85%, so that the vaccine is relatively high in
antibody positive conversion rate;
carrier protein plays a role in transforming the bacterial polysaccharide from a T-
cell-independent antigen into a T-
cell-dependent antigen, and also can be used for preventing diseases caused by
hepatitis B virus; and by adopting the bacterial polysaccharide protein
conjugate vaccine disclosed by the invention, the problem of performing immunization
inoculation on infants and young children under 2 years old can be solved, the function of one injection with multiple
immune effects also can be achieved, and the use crowd and coverage rate of the vaccine can be expanded.