78 results about "Reproductive system disease" patented technology

The invention discloses a probe set for detecting whole exons of extended genetic diseases. The probe set for detecting the whole exons of the extended genetic diseases comprises a standard whole exonprobe set, a whole genome copy number variation probe, and a mitochondrial loop full-length probe, and the genetic diseases comprise 6161 genetic diseases; the standard whole exon probe set can detect the genetic diseases caused by whole exon mutation, the genetic diseases comprise nervous system diseases, metabolic system diseases, endocrine system diseases, digestive system diseases, skeletal system diseases, urinary system diseases, immune system diseases, cardiovascular system diseases, blood system diseases, integument system diseases, ophthalmic system diseases, ear system diseases, respiratory system diseases, and genital system diseases; and the density of the mitochondrial probe is 6X; test samples comprise blood, fresh tissue, FFPE samples, and saliva. The invention discloses using method and kit and application of the probe set for detecting the whole exons of the extended genetic diseases.

[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I):[wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].

[PROBLEMS]To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases.[MEANS FOR SOLVING PROBLEMS]The compound, which is for use as an active ingredient, is represented by the formula (I):[wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4)(wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents —O—, —NH—, etc.; and Y1, Y2, Y3, and Y4 each independently represents —CH—, —N—, etc.].

[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I):[wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].

The invention provides a goat reproduction method applicable to goat raising areas with fewer high-quality stock rams and larger goat flock quantity. The method can improve the mating efficiency of goats by multiple times and facilitates grazing fattening of nanny goats. The mating capacity of excellent stock rams can be developed sufficiently, the utilization of the rams is improved, improvement is accelerated, the feeding number of the stock rams can be reduced, the fodder cost can be saved, the conception rate of the nanny goats can be increased and infectious diseases and reproductive system diseases are prevented. An artificial fertilization mode is adopted, the infectious diseases among the goat flocks due to mating can be avoided, the conception rate of the nanny goats is increased, and the reproduction capacity of the goat flocks is improved.

This invention provides a combination of microRNAs for evaluating the physiological and / or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum / plasma of a subject; and a method for evaluating the physiological and / or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum / plasma of a subject; and a kit for evaluating the physiological and / or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum / plasma of a subject; and a biochip for evaluating the physiological and / or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum / plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute / chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute / chronic infectious diseases caused by various pathogenic microorganisms; other acute / chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

The compound vagina-cleaning flavescent sophora lotion is prepared with 13 kinds of Chinese medicinal materials including flavescent sophora root, cnidium fruit, rhubarb, atractylodes rhizome, morinda root, etc. and through advanced technological process. It has obvious treating effect and less toxic side effect. Its indications include senile vaginitis, infusorial vaginitis, various cervicitis, vaginal ulcer and women's genital system diseases.

A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided. The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.

The invention features methods for treating, preventing or modulating a neurological disease or disorder, or for modulating an anaesthetic or a fertility process by administering compounds that modulate ABCA1 expression or activity. The invention also features methods for identifying compounds useful for such methods.

The invention discloses a compound flavescens cleaning yin flushing liquid, which is characterized in that it is made of the following traditional Chinese medicines in proportions by weight: flavescens, cnidium, rhubarb, atractylodes, Morinda officinalis, Smilax cocos, white moss bark, Phellodendron cortex, coix seed, Kochia scoparia, saponins, safflower, dried alum. Pure natural Chinese herbal medicine is selected, formulated according to the theory of traditional Chinese medicine, after strict screening, processed separately, and combined with modern advanced technology. The preparation is made of pure Chinese herbal medicine, has little toxic and side effects, treats both symptoms and root causes, has remarkable curative effect, clinical symptoms disappear quickly, and there is no rebound phenomenon after being cured. Indications include senile vaginitis, trichomonas vaginitis, fungi, gonorrhea, bacteria and mycoplasma and chlamydia cervicitis, vaginal ulcers, menopausal vaginal dryness and other women's reproductive system diseases.

The present invention relates to a Chinese medicine preparation Xiaoyang Suoyin Ye liquor with the functions of killing bacteria, relieving inflammation and promoting vaginal contraction for effectively curing the diseases of female genital system with excellent therapeutic effect. Said Chinese medicine preparation is made up by using 26 Chinese medicinal materials of moutan flower, carthamus flower, wild chrysanthemum flower, rose, pomegranate flower, Chinese yam and others through a certain preparation process.

A compound represented by the general formula (I-a):[wherein R1a and R2a each means hydrogen, lower cycloalkyl, lower alkyl, etc.; R3a means hydrogen, lower cycloalkyl, lower alkyl, etc.; R4a and R5a each means lower alkyl, lower cycloalkyl, etc. or R4a and R5a are bonded to each other to form lower cycloalkylidene; and R6a means lower alkyl, lower haloalkyl, etc.]. This compound functions as an LCE inhibitor and is useful as a therapeutic agent for various circulatory diseases, nervous diseases, metabolic diseases, reproductive diseases, digestive tract diseases, neoplasm, infectious diseases, etc.

The invention belongs to Chinese medicine preparation; the raw material formula for the preparation of the gel comprises peony, safflower, rose, mother chrysanthemum, pomegranate blossom, Campsis grandiflora, rosemary, lotus, peach blossom, China rose, honeysuckle, freshwater sponge, marigold, jasmine flower, stramonium, Flos Magnoliae officinalis, Chinese gall, radix sophorae falvescentis, Leonurus heterophyllus, purslane, myrrh, garden balsam seed and yam, the raw materials are extracted based on different weights to prepare original liquid medicine in which sodium benzoate is added as an antiseptic in a proportion of 3 per mill, carboxymethylcellulose sodium is formulated with purified water to a status that 6% thereof is substrate, the substrate is soaked uniformly and is added with the original liquid medicine in a proportion of 1:2, and after the uniform stirring, the gel is formed; the filling amount is 3g each gel; the medicine is used for treating diseases of female reproductive system, and can not only reach expelling of toxin and inflammation reduction, but also promote the shrinkage of the vagina; the invention also has the characteristics of multi-functions, no side effect, good treatment effect and convenient usage.

The invention provides a rare golden carp beta type estrogen receptor and an encoded gene thereof. The invention also provides a method for detecting the chemical toxicity of an aquatic environment and a kit for diagnosing the diseases of aquatics. The method and the kit both relate to the detection of the expression level of the receptor. The invention is applied to detecting the chemical toxicity of the aquatic environment and diagnosing the diseases of aquatics, in particular the piscine genital system diseases, thereby realizing the aim of regulating the piscine reproductive ability. Experimental results show that: the expression of the GrER beta gene has a dosage-effect relationship with the estrogen effect; therefore the method has the advantage of simple, quick and correct operation.

The invention belongs to the technical field of medicinal chemistry and particularly relates to an icariin H1 crystal form, as well as a production method, a pharmaceutical composition and an application thereof. The crystal form is represented through an X-ray powder diffraction pattern. The preparation method comprises the following steps: dissolving the icariin by a single solvent or a mixed solvent, suspending under room temperature, performing vacuum drying on the centrifuged solid or drying at the temperature of higher than 100 DEG C. The pharmaceutical composition comprises the icariin H1 crystal form and a pharmaceutically acceptable carrier. The icariin H1 crystal form is applied to prepare a medicine for preventing the immune system disease, the tumor tissue disease, the genital system disease, the endocrine system disease, the bone tissue disease, the disease of cardiovascular system and the disease of central nervous system. The icariin H1 crystal form provided by the invention is simple in preparation method operation, easy to control in the crystallizing process, high in degree of crystallinity, good in crystal form reproducibility and good in stability.

The invention discloses use of radix morindae officinalis polysaccharide in preparation of medicines or health foods for preventing and treating male reproductive system diseases. The radix morindae officinalis polysaccharide has an average molecular weight of (1.0-1.5)*10<4>, and the dosage of the radix morindae officinalis polysaccharide is 200-300mg kg<-1>; after being directly used for preparing the medicines or the health foods for preventing and treating the male reproductive system diseases, the radix morindae officinalis polysaccharide can repair the injury to a male reproductive system, promote spermatogenic function, improve sexual behavior ability, enhance reproductive capacity and increase the testosterone level in a body, so that the technical problem that radix morindae officinalis has toxicity for liver and kidney when being directly eaten is avoided.

The invention discloses a method and a device for performing artificial insemination on cows. An anti-contamination outer sleeve is inserted into the deep of a cow vagina before a semen deposition gun is inserted into the cow vagina. One hand is deeply inserted into the rectum to perform artificial insemination operation. After the hand in the rectum catches the cervix uterus, the other hand holds the semen deposition gun and enables the head of the semen deposition gun to be inserted into the cow cervix uterus to perform semen deposition through a semen deposition gun inserting hole of the anti-contamination outer sleeve, so that the step of cleaning and disinfecting the cow vulva is omitted, and contamination of the semen deposition gun is avoided. According to the method and the device for performing the artificial insemination on the cows, the artificial insemination technology is improved scientifically in an easily-grasping mode. By means of the anti-contamination outer sleeve, the cleaning and the disinfecting of the cow vulva are not needed, contamination caused in the artificial insemination process is avoided, occurrence of reproductive system diseases is reduced, the inseminated rate of cattle is improved, and the conception rate of the artificial insemination of the cows is improved.

The invention discloses a medicament for treating hysteromyoma and ovarian cysts, belongs to a traditional Chinese medicine preparation and particularly relates to a medicament for treating diseases of a female reproductive system. The medicament is mainly prepared from the following raw materials in parts by weight: 10 parts of peach seed, 10 parts of safflower, 10 parts of Szechuan lovage rhizome, 30 parts of radix salviae miltiorrhizae, 3 parts of costustoot, 20 parts of nutgrass galingale rhizome, 10 parts of common burreed rhizome, 10 parts of rhizoma zedoariae, 10 parts of eupolyphaga, 10 parts of leech, 10 parts of trogopterus dung, 10 parts of crude pollen typhae, 15 parts of rhizoma corydalis, 15 parts of turmeric root-tuber, 15 parts of cyathula root and 10 parts of Chinese honeylocust spine. Peach seed, safflower, radix salviae miltiorrhizae, eupolyphaga, leech, trogopterus dung, crude pollen typhae, rhizoma corydalis and cyathula root have the effects of promoting blood circulation and removing blood stasis, Szechuan lovage rhizome has the effects of activating qi and removing blood stasis, costustoot, nutgrass galingale rhizome, common burreed rhizome, rhizoma zedoariae and turmeric root-tuber have the effects of activating qi and promoting blood circulation, and Chinese honeylocust spine has the special function of breaking the cysts. Clinic practices prove that the medicament has definite treatment effect and can cure the hysteromyoma and the ovarian cysts generally after a patient take 30-40 doses.

[PROBLEMS]To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases.[MEANS FOR SOLVING PROBLEMS]The compound, which is for use as an active ingredient, is represented by the formula (I):[wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4)(wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents —O—, —NH—, etc.; and Y1, Y2, Y3, and Y4 each independently represents —CH—, —N—, etc.].

A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided.The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.

The invention discloses a cervical cancer staging method based on cervical exfoliated cell gene detection. The cervical cancer staging method based on cervical exfoliated cell gene detection comprisesthe steps of acquiring a cervical exfoliated cell and a viable tissue, extracting whole genome deoxyribonucleic acid (DNA), detecting a gene, and carrying out immunohistochemical examination. The invention further discloses a cervical cancer staging detection kit based on cervical exfoliated cell gene detection. The kit comprises PCR reaction liquid containing a specific primer. According to thecervical cancer staging method based on cervical exfoliated cell gene detection and the cervical cancer staging detection kit based on cervical exfoliated cell gene detection provided by the invention, exfoliated cells of normal cervical epithelium, pre-cancerous diseased cervical epithelium and cervical cancer are subjected to DNA quantitative detection, so that the relevance of P53 and P16 and the cervical cancer occurrence and development is illuminated from the angle of the exfoliated cells, and a new basis is provided for the cervical cancer staging diagnosis; DNA in the cervical exfoliated cell is extracted so as to be detected, so that the advantage of low sampling quantity is realized; and materials are drawn simply, conveniently and non-invasively, a patient has no discomfort, anda sample to be detected can be obtained during the routine examination of the reproductive system diseases in the obstetrics and gynecology department, so that the cervical cancer staging method based on cervical exfoliated cell gene detection and the cervical cancer staging detection kit based on cervical exfoliated cell gene detection provided by the invention have the advantages of non-invasive material drawing, small side effect and good patient compliance.

The invention relates to a formula for treating prostatitis and other male reproductive system diseases. The invention discloses a main compound extracted from mangosteen: Garcinia Mangostana, wherein alpha-mangostin is taken as a main effective constituent and mixed with various commonly used fillers in the medicine industry to prepare various appropriate preparation formulations including tablets, capsules, powder, and suppository; and the various preparation formulations can be used for preventing and treating male reproductive system inflammations such as prostatitis, orchitis, deferentitis and urethritis by means of oral taking or external application. The content of the alpha-mangostin in the product is between 3 and 99.8 percent; and the prepared product can relieve various inflammations, has the function of relieving pain to certain degree, and can be independently used or mixed with other natural substances for use.

The Chinese medicine composition is prepared with tuckahoe, honeysuckle, bezoar, antelope horn powder, oriental water plantain and other seven kinds of Chinese medicinal materials. The present invention also relates to the preparation process of the Chinese medicine composition, the use of the Chinese medicine composition in preparing medicine, and the medicine with the Chinese medicine composition as active components and thus possessing the functions in resisting inflammation, clearing heat, relieving pain and promoting diuresis.

The invention provides a preparation method of a plant cell enzymolysis extract for treating a female HPV, and relates to the technical field of biological pharmacy. The preparation method of the plant cell enzymolysis extract comprises the steps that fresh garlic is peeled, lemons are thoroughly cleaned and sliced after seed removal, and the garlic and the lemon are mixed and crushed and pass through a 10-20 mesh sieve to obtain a mixture for use; according to the mass ratio of 1:1, edible aged vinegar is added in the prepared mixture, an obtained solution is placed in an enzymolysis container, starch protease is added, and high-speed rotary stirring is conducted for 20-30 minutes, wherein stirring is conducted once every day and continuously conducted for 5-6 days; then a cell fusion enzyme is added in the container, and standing is conducted for 30-40 days; separation and purification are conducted at room temperature, an extract is subjected to clarification filtration to be 200 mesh, sodium carboxymethyl cellulose is added according to the mass ratio of 1:0.25 for mixing, and the plant cell enzymolysis extract can be obtained. The obtained extract can strongly kill the human papilloma virus (HPV), block and reduce the incidence of female cervical cancer and effectively treat female reproductive system diseases.

The invention relates to a preparation method for coptis chinensis total alkaloid effervescent tablets. The method comprises the following steps: crushing a proper amount of the entire plant of the coptis chinensis into thick powder; adding an aqueous solution of sulphuric acid to the thick powder, wherein the volume of the aqueous solution of the sulphuric acid is 4-15 times the volume of the thick powder, the concentration of the the aqueous solution of the sulphuric acid is 0.1-1%; carrying out soak extraction at a room temperature for 24 hours, and carrying out filtering for 2-5 times; adding lime cream to the resulting extracting solution to adjust a pH value to 7, standing for 8-12 hours, then carrying out filtering; adding concentrated hydrochloric acid to the resulting extracted solution to adjust the pH value to 2-3, standing for 8-12 hours, then carrying out filtering; adding water to the precipitation to boil and dissolve the precipitation, wherein the volume of the water is 50 times the volume of the precipitation; adding the lime cream to the precipitation to adjust the pH value to 8-9, then carrying out filtering while hot; carrying out steps of washing through the water, water pumping out and drying for the resulting filtrate to obtain the coptis chinensis total alkaloid a; ; dissolving 2-5 parts of polyethylene glycol 6000 in 5-15 parts of ethanol, then adding 15-30 parts of sodium bicarbonate to obtain a mixed solution b comprising the sodium bicarbonate, the polyethylene glycol and the ethanol; adopting a spraying starch adsorption drying method in the preparation method for the micro encapsulate to spry the b through a nebulizer in a rotation coating pan filled with the a; adopting a II sieve for the treated b to pelletize into the C; adopting the II sieve for citric acid to pelletize into citric acid particles; adopting a VII sieve for the citric acid particles and the C, then uniformly mixing the screened citric acid particles and the C, carrying out tabletting, wherein the weight of each tablet is 1 g, and the infrared ray is adopted for irradiating the position of the filler inlet during the tabletting process. The effervescent tablets provided by the present invention is easy to be carried, has rapid onset, and provides high and exact therapeutic effects for treatment of the female reproductive system diseases.

The invention belongs to the technical field of medicine chemistry, and particularly relates to an icariin H2 crystal form, a preparation method of the icariin H2 crystal form, a medicine composition and an application. The crystal form is represented by virtue of an X-ray powder diffraction pattern. The preparation method comprises the following steps: dissolving icariin by utilizing mixed solvent, drying the icariin at the temperature of 50 DEG C, or suspending the icariin at the room temperature after the icariin is dissolved, drying the centrifuged solid. The medicine composition comprises the icariin H2 crystal form and a carrier acceptable on the medicine; the icariin H2 crystal form is applied in the medicine for preventing diseases of immune system, tumor tissue diseases, diseases of reproductive system, diseases of endocrine system, bone diseases, diseases of cardiovascular system and diseases of nerve and metal system. The preparation method of the icariin H2 crystal form is simple to operate, easy to control, high in crystal degree, good in repetition and good in stability.

The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and compositions relating to pre-term labor, uterine diseases and conditions, and ovarian conditions and diseases. In certain embodiments, such methods and compositions involve a COMT inhibitor.

The invention belongs to the technical field of medicinal chemistry and particularly relates to an icariin form-alpha crystal, a preparation method thereof and a medicinal combination and application thereof. The crystal is represented through an X-ray powder diffraction diagram; the preparation method thereof comprises the step of heating icariin to 180 DEG C; the medicinal combination comprises the icariin form-alpha crystal and pharmaceutically acceptable carriers; the icariin form-alpha crystal is applied to the medicines for preventing and treating immune system diseases, tumor tissue diseases, genital system diseases, endocrine system diseases, bone tissue diseases, cardiovascular system diseases and nervous system diseases. The icariin form-alpha crystal provided by the invention has the advantages that the preparation method thereof is simple to operate, the crystallization process is easy to control, the crystallization degree is high, the reproducibility of the crystal is good and the stability is good.