50 results about "Purine metabolism" patented technology

The invention relates to a drug for treating purine metabolic disorder disease, provides a flavonoids compound represented by the formula (I) and a modified derivative thereof, and a use in inhibition of xanthine oxidase activity and promotion of uric acid excretion function, wherein R1, R2 and R3 independently represent -H or monosaccharide residues, and R4 represents -H or -OH. In particular, the drug is used for treating purine metabolic disorder disease, and can be used for treating hyperuricemia and related diseases and reducing a individual serum UA level; the drug is used for treating hyperuricemia; the drug is used for treating the related diseases, such as for treating gouty arthritis and arthrophlogosis caused by hyperuricemia, and for treating chronic interstitial nephritis, kidney stones and the like caused by hyperuricemia. The drug has the advantages of natural chemical structure, safety, low toxicity, rapid curative effect and fewer side effects. (I).

The invention relates to a formulated foodstuff with special medical purposes for patients with hyperuricemia and gout and provides a granule or powder solid beverage formed by mixing both medicinal and edible plants and extract thereof and a nutrient supplement. The granule or powder solid beverage contains submicron powder of green papaya, banana peel extract, green tea extract, sweet potato vine extract, kudzu vine root extract, Poria cocos extract, lotus leaf extract, cape jasmine extract, haw extract, licorice extract, stevia rebaudiana extract, xylo oligosaccharide, dipotassium hydrogen phosphate, sodium bicarbonate, vitamin C and nicotinamide. The granule or powder solid beverage provided by the invention is mainly directed at the characteristic of purine metabolism disorders of patients with hyperuricemia and gout, improves the complex process of biochemical metabolism like protein metabolism, purine metabolism and lipid metabolism in the bodies of patients with hyperuricemia and gout in virtue of special physiological active substances and targeted micronutrients included in the granule or powder solid beverage, indirectly inhibits synthesis of uric acid, promotes acid discharging and maintains nutrition functions like acid-base balance of the body.

The invention discloses an oral administration pharmaceutical composition for treating gout, wherein the active constituents include the following raw material herbs (by weight portion): rhubarb horsetails 9, plantain seeds 6, achyranthes and cyathula root 6, ledebouriella root 3, prepared Sichuan aconite root 6, spatholobus stem 9, Clematis chinensis 5, poria cocos 6, cassia twig 8, rhizoma dioscoreae hypoglaueae 8, coralbean bark 6 and barrenwort 4.

The invention relates to a traditional Chinese medicine composition for treating gout, which comprises the following raw material medicine components in proportion by weight: 10-40g of caulis lonicerae, 5-20g of gentiana macrophylla, 5-20g of dried rhizome of rehmannia, 15-45g of ramulus mori, 5-12g of prepared radix aconiti, 5-12g of prepared kusnezoff monkshood root, 3-10g of liquorice, 5-25g ofrhizoma anemarrhenae, 2-10g of aconite, 5-25g of angelica, 5-25g of pawpaw, 5-25g of root of radix stephaniae tetrandrae, 5-25g of alisma orientale, 10-50g of coix seed, 5-25g of tuckahoe and 5-25g of clematis chinensis. The medicine formulations are fine selected, and through dialectic compatibility, the medicine components are complementary on action, have synergetic functions, can promote blood circulation, regulate purine metabolism, inhibit uric acid formation, enhance human immunity, and achieve the purpose of treating both principal and secondary aspects of diseases. The medicine composition has convenient preparation, wide medicinal resources, low cost, rapid curative effect, high cure rate and no toxic or side effect. Clinical application proves that the total effective rate reaches more than 90 percent, and the cure rate reaches 60 percent.

The invention provides a solid product of compound chicory root for adjusting disturbance of purine metabolism and a preparation method of the solid product. The product can be applied to disturbanceof purine metabolism of hyperuricemia groups and preventing hyperuricemia complication. The solid product adopts natural edible Chinese herbal plants: chicory root, fructus gardeniae and rhizoma alpiniae officinarum, the main agent is extracted through refining extraction, and then scientifically matched with sodium citrate, thus the solid product is prepared, does not contain any artificial synthetic substances, and is all natural. The solid product can enhance purine metabolism of a human body, adjusts engine body and visceral organs, is beneficial for relieving pain and red heat symptoms ofa patient, gradually adjusts the operational situation of body organs, and adjusts damaged internal secretion of organisms. The technology is simple, the cost is low, the effective part can be easy to obtain, the preparation method is suitable for industrialized production, and the solid product can be used for preparing food, drugs and health care products for improving disturbance of purine metabolism of the hyperuricemia groups and preventing hyperuricemia complication.

The present invention discloses a composition for promoting uric acid reduction. The composition comprises the following components in parts by weight: 10-25 parts of poria cocos, 10-25 parts of coixseeds, 10-20 parts of kudzuvine roots, 7-14 parts of psyllium seed husk powder, 8-16 parts of chia seed powder, 0.5-3 parts of skipjack elastin and 100 parts of auxiliary materials. The composition has the synergistic effect in a plurality of aspects such as reducing blood sugar, blood fat and cholesterol, promoting uric acid excretion, promoting the balance of ion metabolism of the body and promoting the balance of sputum metabolism, thereby jointly inhibiting the production of uric acid, increasing the excretion of uric acid and promoting the reduction of uric acid. The present invention also provides a preparation method of the composition. The preparation method subjects the poria cocos, the coix seeds and the kudzuvine roots to steaming, drying and pulverizing, and mixing the obtainedmixture with other components to obtain the composition suitable for administration.

The invention relates to a method for preparing a traditional Chinese medicine preparation by use of a ground beetle extract combined with a modern technology according to records of traditional Chinese medicines. The method comprises the following steps: (1) preparing a ground beetle extract liquor; (2) performing ultrafiltration by an ultrafiltration membrane; (3) filtering by a nanofiltration membrane; (4) sterile-freezing and drying to prepare freeze-dried powder; (5) preparing capsules and powder-injection. The traditional Chinese medicine preparation prepared by the ground beetle extract according to the preparation method not only has the functions of removing blood stasis and promoting reunion of fractured bones verified by practice of traditional Chinese medicine, but also has the effects of improving purine metabolism, adjusting the function of the immune system, enhancing recovery of bone tissue and preventing tumor necrosis factors. In addition, the preparation further has the anti-thrombosis effect and the effect of dissolving thrombus, and has the delaying effect to atherosclerosis. The preparation is an ideal traditional Chinese medicine preparation for treating rheumatic pain, preventing tumor and improving the immunity.

The invention provides a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition prescription comprises the following raw materials in parts by weight: 2-20 parts of meadowrue root and rhizome, 2-16 parts of soulie barberry bark, 2-12 parts of radix sophorae flavescentis, 5-40 parts of lycopodium clavatum, 2-20 parts of buxus microphylla, 2-16 parts of cynoglossum furcatum and 3-18 parts of nightshade. The traditional Chinese medicine composition is capable of improving in-vivo purine metabolism due to excitation, and comprehensively recovering purines to a normal metabolism level; the traditional Chinese medicine composition is capable of rapidly relieving pain and diminishing swelling in case of an acute attack of gout, remarkable in curative effect, and free from any toxic and side effects, blood uric acid is not liable to rebound after stopping medicines, and the deposition of urate in joints and renal parenchyma is prevented. The traditional Chinese medicine composition is great in treatment effect on gout, is few in side effects, and is easily accepted by patients.

The invention discloses health-care bean curd, raw materials of which contain Chinese herbal additive powder A, an iodine-rich additive, Chinese herbal additive powder B, soya-bean milk, mulberry ash, cistanche, motherwort, sharpleaf galangal fruit, radix bupleuri, curcuma tuber, semen litchi, raw rehmannia root, rheum officinale, radix paeoniae rubra, white peony root, haw, dried orange peel, Poria cocos, pectase and cellulose. The invention also brings forward a preparation method of the above health-care bean curd. According to the health-care bean curd prepared in the invention, defects of iodine deficiency and arteriosclerosis caused by food consumption of too much traditional bean curd can be overcome, and gout patients with disorder of purine metabolism and patiens with increased blood uric acid concentration can be avoided from gout flare.

The invention discloses a phellinus igniarius alcohol extract, which is extracted through a following extraction method comprising the steps of after smashing phellinus igniarius, soaking with 80 to 95 percent ethyl alcohol in 6 to 8 times of volume for 12 to 36 hours, ultrasonic extracting for 3 to 5 times, recovering the ethyl alcohol, and concentrating to obtain a brown paste object. The phellinus igniarius alcohol extract provided by the invention can be beneficial to reducing renal function biochemical criterions such as blood urea and serum creatinine, improving a renal function, and reducing the pathological damage of adenine metabolite on a kidney so as to have a better protection function, provides a new medicine for clinically treating uremia, and has a wide application prospect.

The invention provides a health-care medicine for treating gout, which is composed of saffron, safflower, folium artemisiae argyi, Herba Lysimachiae, natural coarse salt grain, pepper, dried ginger, evening primrose and other natural Chinese medicinal herbs. The Chinese medicinal herbs are ground into powder, proportionally and uniformly mixed, and decocted into a decoction for immersing feet. The medicine fully utilizes the actions of the pharmaceutical components, and can treat gout caused by increased metabolite uric acid concentration in the human body due to purine metabolism disorder, and beriberi, onychomycosis, eczema and other diseases caused by spleen and stomach injury, transformation disorder, exopathogen invasion, unsmooth qi and blood due to retention of pathogens in muscle joints, stasis due to blood heat, collateral channel blocking and the like.

The invention discloses a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition comprises the following active pharmaceutical ingredients in parts by weight: 25-40 parts of rhizoma smilacis glabrae, 8-12 parts of peach kernel, 8-12 parts of radix paeoniae rubra, 8-12 parts of clematis root, 8-12 parts of angelica, 8-12 parts of Szechuan lovage rhizome, 8-12 parts of carthamus tinctorius, 10-20 parts of rhizoma dioscoreae hypoglaueae, 10-20 parts of zaocys dhumnade, 10-20 parts of piper wallichii, 1-6 parts of centipedes, 1-8 parts of scorpions and 8-12 parts of lumbricus. A preparation method of the traditional Chinese medicine composition comprises the following steps: directly crushing the active pharmaceutical ingredients subjected to conventional treatment into fine powder; screening the fine powder with 100 meshes; after uniform mixing, preparing capsules of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the advantages that rhizoma smilacis glabrae and rhizoma dioscoreae hypoglaueae are utilized for detoxication and dehumidification, and easing of joint movement; peach kernel, carthamus tinctorius, angelica, radix paeoniae rubra, Szechuan lovage rhizome and lumbricus are utilized for activating blood circulation to dissipate blood stasis, and activating meridians to stop pain; clematis root, piper wallichii, zaocys dhumnade, centipedes and scorpions are utilized for expelling wind-damp, activating the meridians, and stopping arthralgia; through the combination of such active pharmaceutical ingredients, swelling and hot pain of a joint can be remarkably relieved, and the functional movement of the joint can be improved; moreover, purine metabolism balance in a human body can be adjusted, the contents of blood uric acid and C-reactive protein can be lowered, and the effects of activating blood circulation to dissipate blood stasis, and relieving swelling and stopping pain can be realized.

The invention relates to the field of health care products, particularly to a traditional Chinese medicine composition, a preparation method thereof and a prepared health care wine. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 5-15 parts of bilberry, 5-15 parts of sambucus chinensis, 5-15 parts of rhodiola rosea, 5-15 parts of glossy ganoderma, and 10-20 parts of grape seed. The traditional Chinese medicine composition provided by the invention is prepared from the raw materials in a specific ratio, the prepared traditional Chinese medicine composition is high in effective active components, and can well repair the metabolizing function of a human body, so that the human body can normally function well, the traditional Chinese medicine composition has good repairing function for the purine metabolic disturbance of the human body, and has remarkable treatment effects on gout and rheumatic type diseases caused by purine metabolic disturbance; in addition, the traditional Chinese medicine composition has the efficacy of improving the immunity of the human body. The traditional Chinese medicine composition performs water extraction on the raw materials in a heating and distillating manner, the effective active components are effectively merged at a high temperature, and the traditional Chinese medicine composition has a better effect.

The invention relates to application of ergot sterone in the preparation of medicaments for treating chronic renal failure. The ergot sterone has the effects of lowering urea nitrogen and serum creatinine, improving the renal function and reducing the pathological damage of adenine metabolites to the kidney. The invention provides a novel medicament for clinically treating chronic renal failure caused by adenine, aristolochic acid, rhubarb and the like.

The invention provides application of a purine metabolism marker in preparation of a reagent for screening and diagnosing acquired drug resistance of a lung cancer molecular targeted drug. The purine metabolism marker is one or more of adenosine monophosphate, guanosine monophosphate, inosine monophosphate, xanthosine monophosphate, adenosine, guanosine, inosine, xanthosine, adenine, guanine, hypoxanthine, xanthine and uric acid. The metabolic marker has good diagnostic potential for acquired drug resistance of the lung cancer molecular targeted drug, can be used for diagnosis and curative effect monitoring of acquired drug resistance of the lung cancer molecular targeted drug, and has good guiding significance for development of subsequent clinical application research.

The invention relates to a Chinese medicine, in particular to a medicine for treating gout. The medicine can relieve toxic and side effects of reduced medicinal effects or serious adverse reactions generated by taking western medicines for a long time, is prepared from the following raw materials in part by weight: 10 to 36 parts of ampelopsis grossede, 20 to 50 parts of aspidopterys glabriuscula, 20 to 35 parts of giant knotweed rhizome and 10 to 30 parts of clerodendranthus spicatus, and is boiled in water and taken before dinner. The medicine for treating the gout has unique curative effects, is low in cost, addresses both the symptoms and root causes, does not have any side effect, improves purine metabolic disturbance fundamentally, and regulates the immune function of organisms comprehensively.

The present invention belongs to the technical field of medicine preparations and relates to a yeast fructose composition affecting purine metabolism. The active ingredients comprise a yeast extract and D-fructose; the active ingredients are mixed according to the mass ratio and the mixture is prepared into granules or solution by using conventional processes; wherein a high yeast feed is prepared by the following steps: a commercial granule feed for rats is crushed, then the yeast extract is added evenly into the feed, and finally the mixture is manufactured into the granules with original shapes and sizes; the fructose aqueous solution is prepared by the following steps: the D-fructose is dissolved in pure water and prepared into the fructose solution; wherein the commercial granule feed for the rats comprises crude proteins, crude fats, crude fibers, crude ash, calcium and phosphorus; the high yeast feed and the fructose aqueous solution are used as a package composition for a combined feeding of animals; the operation is easy to master and avoids animal damages caused by long-term gavage or injection; and the composition is scientific in formula, simple in preparation processes, even in effective ingredients, reasonable in ingredient matching, good in use effects, and easy in feeding.

The invention relates to the fields of food and medicine, and especially relates to a tea and a health food for treating gout and a medical application thereof. A preparation method of the health food comprises the following steps: A) selecting fresh clean yellow horn twig and leaves parts without insect disease and pesticide residue; and B) frying, twisting, and drying the material to prepare a traditional Chinese medicinal material and the health food used for a decoction and a paste agent capable of making and extracting. The health food has the beneficial effect that a making form of the yellow horn branches and leaves decoction or the tea for population with gout and purine metabolism unusual diseases is compared with benzbromarone (benzbromarone tablets) oral administration, 95% of patient symptom is mitigated or disappeared, toxic and side effect is not found, and the effect is more obvious.

The invention discloses an external scouring bath medicine for treating gout, and belongs to the technical field of medicines. By the external scouring bath medicine, the problem that western medicines for treating gout only can relieve the state of illness but not address root causes in the prior art and the problem that the western medicine has toxic and side effects on liver and kidney of a human body after long-term administration are solved. The external scouring bath medicine consists of the following Chinese herbal medicines by weight: 8 to 12 grams of safranine, 25 to 35 grams of zanthoxylum, 25 to 35 grams of drug sweetflag rhizome, 25 to 35 grams of mulberry twig, 25 to 35 grams of asiaticwormwood, 17 to 23 grams of garden balsam stem, 17 to 23 grams of prepared common monkshoodmother root, 17 to 23 grams of prepared kusnezoff monkshood root, 17 to 23 grams of divaricate saposhnikovia root, 17 to 23 grams of pubescent angelica root and 17 to 23 grams of halite. According tothe external scouring bath medicine, the selected Chinese herbal medicines are complementary with each other and have a synergistic effect, so the external scouring bath medicine can promote blood circulation, regulate purine metabolism, inhibit the formation of trioxypurine and enhance the immunity of the human body to fulfill the aim of addressing root causes and symptoms.

The invention provides an oral traditional Chinese medicine for treating gout and tophi. Gout refers to a group of genetically related diseases of disturbance of purine metabolism, comprises primary gout and secondary gout and has the clinical characteristics of hyperuricemia as well as gouty arthritis, tophi and renal lesions caused by hyperuricemia. Gout always occurs after liquor drinking for the first time, patients often have intense pain in toe joints at midnight, the toe joints get red, swollen and hot, great toes of 60% of the patients are under attack during first occurrence, attack can also spread to other joints, and repeated occurrence is possible. The oral traditional Chinese medicine for treating gout and the tophi comprises raw materials in parts by weight as follows: 6 parts of bulb of edible tulip, 12 parts of os sepiae, 4 parts of baking soda, 3 parts of inonotus obliquus, 5 parts of radix et rhizoma nardostachyos, 5 parts of herba lycopodii, 6 parts of scandent schefflera stem and leaf, 3 parts of radix salviae miltiorrhizae, 3 parts of radix angelicae sinensis, 4 parts of peach flower, 5 parts of radix glycyrrhizae, 5 parts of rhizoma ligustici, 3 parts of rhizoma cyperi and 3 parts of caulis cucurbitae. The invention applies to the oral traditional Chinese medicine for treating gout and the tophi.

The invention relates to the field of medical examination, in particular to a kit for liver cancer detection. The kit has the advantages of convenience, rapidness, sensitivity and the like as the kitis stable in property, convenient to use and low in cost. Purine metabolites and phospholipid metabolites are detected, so that liver cancers can be rapidly, sensitively and effectively screened and judged, missed diagnosis rate is decreased, the infiltration degree of the liver cancers can be bidirectionally detected, and the kit has great clinical application values for diagnosis and disease risk ranking of patients. By means of detection, disease risk assessment is assisted, so that early diagnosis of the patients is realized. The kit has important guiding significance for pharmaceutical orsurgical curative effect observation, and specimens can be simply, conveniently, more economically, safely and effectively detected.

The invention relates to application of ergot sterone in the preparation of medicaments for treating chronic renal failure. The ergot sterone has the effects of lowering urea nitrogen and serum creatinine, improving the renal function and reducing the pathological damage of adenine metabolites to the kidney. The invention provides a novel medicament for clinically treating chronic renal failure caused by adenine, aristolochic acid, rhubarb and the like.

The invention discloses a nucleotide sequence and protein sequence of a novel OsXDH (oryza sativa xanthine dehydrogenase) gene and a function of the OsXDH gene in delaying leaf senescence through overexpression, and belong so the field of genetic engineering. The cDNA (complementary deoxyribonucleic acid) sequence of the OsXDH is shown in the SEQ ID NO.1 and a coded amino acid sequence is shown in the SEQ ID NO.2. The novel OsXDH gene plays an important role in a purine metabolism process and catalyzes xanthine and hypoxanthine to generate uric acid. MRNA (messenger ribonucleic acid) expression analysis shows that the gene shows constitutive expression, and overexpression of the gene can delay oryza sativa senescence. Transgenic experiments prove that the gene has the function of delaying oryza sativa senescence, and on the basis of the function of the OsXDH gene in delaying of oryza sativa senescence through overexpression, the gene can be used for genetic breeding of oryza sativa.

The invention provides an external medicine for treating gout and rheumatism by sweat gland dredging, which is composed of saffron or safflower, folium artemisiae argyi, Herba Lysimachiae, natural coarse salt grain, pepper, dried ginger, evening primrose and other natural Chinese medicinal herbs. The Chinese medicinal herbs are ground into powder, proportionally and uniformly mixed, and decocted into a decoction for immersing feet. The external medicine fully utilizes the actions of the pharmaceutical components, and can treat gout caused by increased metabolite uric acid concentration in the human body due to purine metabolism disorder, and beriberi, onychomycosis, eczema and other diseases caused by spleen and stomach injury, transformation disorder, exopathogen invasion, unsmooth qi and blood due to retention of pathogens in muscle joints, stasis due to blood heat, collateral channel blocking and the like.

The invention relates to the technical field of selenium wine, and discloses selenium wine for protecting liver and preventing liver diseases, which comprises the following components: a wine base, selenium-rich shepherd's purse plant crushed powder, a new food raw material, a medicinal plant, a medicinal animal and a medicinal animal product, the invention discloses selenium-enriched shepherd's purse wine, which is characterized by being prepared from the following components in parts by weight: 200 to 250 parts of wine base, 20 to 25 parts of selenium-enriched shepherd's purse plant crushed powder, 10 to 15 parts of new food raw materials, 10 to 15 parts of medicinal plants, 50 to 75 parts of medicinal animals and 5 to 10 parts of medicinal animal products. Phytosterol, horseradish tree leaves, Acai fruits, astragalus membranaceus, lalang grass rhizome, endive and cynanchum auriculatum all have a liver protection effect, so that reduction of hepatic glycogen can be prevented; according to the present invention, the purine metabolism efficiency is improved by mixing the Szechwan-Yunnan sanicle root, the lindera aggregata leaf, the emblic leafflower fruit and the radix fici simplicissimae so as to be used together, such that the uric acid content in the blood is reduced, and the gout caused by hyperuricemia is avoided.

The present invention provides a system and method of maintaining and / or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein the availability of adenosine or derivatives thereof in the cell is increased and / or prolonged. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved, wherein the availability of adenosine or derivatives thereof in the cell is increased and / or prolonged. The present invention also provides a system and method of maintaining and / or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein at least one purine metabolism enzyme inhibitor is applied to the cell.