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130 results about "Protein Depositions" patented technology

Compositions and methods for the augmentation and repair of defects in tissue

InactiveUS20070065415A1Improve successful adaptationBiocidePeptide/protein ingredientsRepair tissueCultured cell
Compositions and methods of treating a defect in a patient are disclosed, including expanding a culture of autologous cells in vitro to form cultured cells, collecting the cultured cells for introduction into the patient, and depositing the cultured cells with ancillary proteins.
Owner:DASK TECH

Treatment of protein degradation disorders

The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC / TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
Owner:DANA FARBER CANCER INST INC +1

Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix

The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein and / or peptide, and a sparingly water-soluble or essentially insoluble particle. The protein is deposited by adsorption or some other mechanism onto the sparingly water-soluble biocompatible particle wherein the protein-particle combination is dispersed within the polymeric matrix. The deposition of the protein onto the particle acts to modulate the release of the protein or peptide from dosage forms including long-acting dosage systems.
Owner:BTG INT LTD

Method for detecting blood sugar-lowering and blood pressure-lowering drugs in blood by ultra high performance liquid-mass spectrometry

ActiveCN104133006AMeet the requirements of actual testingThe test result is accurateComponent separationRetention timeBlood sugar
The invention provides a method for detecting 31 common blood pressure-lowering and blood sugar-lowering drugs in blood by an ultra high performance liquid-mass spectrometry, and is characterized in that the method comprises the following steps: (1) confirmation of detected target compounds; (2) sample processing: processing a sample by an organic solvent protein-deposition method; (3) primary screening detection: carrying out primary screening detection by a multiple reaction monitoring (MRM) mode of the ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS) in different periods of time; (4) reexamining of the sample which is positive by the primary screening detection in the step (3): after treating and concentrating the sample which is positive by the screening detection, carrying out UPLC-MS / MS detection; and optionally, (5) reexamining of the sample which is positive by the reexamining detection in the step (4): reexamining by a high performance liquid chromatography-high resolution time-of-flight tandem mass spectrometry (HPLC-QTOF). According to a fact that the drugs have different retention time in the set detection conditions, a method for sectional detection is creatively completed. The required time for totally completing the detection of 31 drugs can be within 11 minutes.
Owner:中国民用航空局民用航空医学中心

Method for detecting 25-hydroxy-vitamin D through ultra-performance liquid chromatography-tandem mass spectrometry

The invention provides a method for detecting 25-hydroxy-vitamin D through a high-sensitivity high-throughput ultra-performance liquid chromatography-tandem mass spectrometry device. The method comprises adding an internal standard substance of 25-hydroxy-vitamin D into a serum sample, adding a zinc sulfate solution and a methanol solution into the mixture so that protein deposition is realized, carrying out full mixing, adding a n-hexane solvent into the mixture, carrying out extraction, carrying out full mixing, carrying out centrifugation, taking the supernatant, carrying out nitrogen blowing drying, adding a compounded solution into the supernatant to obtain a sample to be detected, detecting the sample to be detected through an ultra-performance liquid chromatography-tandem quadrupole mass spectrometry device and carrying out quantitation through an internal standard curve method based on 25-hydroxy-vitamin D2 and / or 25-hydroxy-vitamin D3 quantitative and qualitative ion pair retention time as qualitative basis. The method has advantages of simple pre-treatment process, good specificity, good matrix interference resistance, short detection time, high throughput, high detection precision, high sensitivity and low cost.
Owner:袁洪

Grass carp feed premix and application thereof

The invention discloses a grass carp feed premix and application thereof. The grass carp feed premix comprises limited amino acid, compound vitamins and compound mineral salts. In the invention, plant raw materials are used as a main protein source, such as vegetable meals, cotton meals, soybean products, and the like; and if 1 percent of grass carp feed premix is added to prepare a submerged grass carp compound feed or an expanding feed for breeding grass carps, the protein deposition rate reaches 32 percent, the protein efficiency is improved to 1.9, the feed coefficient is reduced to 1.9, and the feed cost is saved y7.31-11.68 percent. The grass carp feed premix has significance for improving the utilization of the feed by the grass carps, promoting the growth, and the like.
Owner:广州市诚一水产科技有限公司

Functional peptide protein powder, and preparation method and applications thereof

The present invention discloses a method for preparing functional peptide protein powder using blood cells of livestock and poultry as raw materials. The method is as follows: continuously centrifuging fresh blood of livestock and poultry to separate blood plasma and blood cells; processing the blood cells by physical and chemical methods to break cell membranes and denature intracellular protein; after the membrane breaking and denaturing process, adding acid (or base) and a protease preparation into the blood cell solution to enzymatically hydrolyze the blood cell protein into small peptides and amino acids containing functional ingredients; then centrifuging the products of enzymolysis and adding acid and a decolorizer to performing decoloration; and finally performing spray drying on the decolorized blood cell solution. The present invention also provides functional peptide protein powder prepared by the method. The functional peptide protein powder has a high protein content, a high essential amino acid content, a high bioactive peptide content, a high digestion and absorption rate, and a strong antioxidant capacity, can improve the disease resistance of livestock and poultry, protein deposition and production performance, can be widely used for livestock, poultry and aquatic animals, and can also be used as a substitute for fish meal and soybean meal.
Owner:北京澳龙港生物技术研究中心

Tilapia feed premix and application thereof

The invention discloses a tilapia feed premix and an application thereof. The tilapia feed premix is composed of limiting amino acid, a vitamin complex and composite mineral salt. In the invention, plant raw materials such as rapeseed meal, cottonseed meal, soybean products and the like are taken as main protein sources, and 1% of the tilapia feed premix is added to the raw materials to prepare a tilapia submerged compound feed or an extruded feed for cultivating tilapia, which can achieve protein deposition rate up to 48%, improve protein efficiency to 2.85, lower feed coefficient to 1.35 and save feed cost by 12.20%-13.90%. The tilapia feed premix of the invention is of great practical significance for improvement of feed utilization of the tilapia, growth promotion and the like.
Owner:广州市诚一水产科技有限公司

Feed capable of reducing Yanan pig back-fat thickness and improving Yanan pig lean meat deposition rate

The invention discloses a feed capable of reducing Yanan pig back-fat thickness and improving Yanan pig lean meat deposition rate. The feed comprises following components in percentage by weight: 55 to 75% of starch type feed, 15 to 20% of protein feed, 1 to 3% of grease, 8 to 15% of fiber feed, 1 to 5% of composite mineral elements and 0.3 to 0.6% of vitamin composite. Through years of practice, researches on nutrition requirement of Yanan pigs, nutrition and meat quality, and exploitation and utilization of novel feed resources, the components and ratio of the Yanan pig feed are scientifically adjusted, so that the utilization rate of the feed is increased, the immunity ability and the health conditions of the Yanan pigs are improved, the back-fat thickness of the Yanna pigs is reduced, and the protein deposition rate and lean meat ratio of the Yanan pigs are increased. Thus the Yanan pork has the advantages of tenderness, redness, and fresh and delicious taste, and the economic efficiency of the breeders is prominently increased.
Owner:SICHUAN AGRI UNIV

New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases

The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and / or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from —C(R1)(R2)—, —C(R3)═, —N(R4)—, —N═, —N+(R5)═, —O— and —S—; M and Z are independently nondirectionally selected from formula (I) and formula (II).
Owner:LUDWIG MAXIMILIANS UNIV MUNCHEN +1

Isolated protein powder prepared by euphausia superba powder

ActiveCN104186911ALow fatWith low fluorineProtein composition from fishProtein solutionPROTEIN S HEERLEN
The invention aims at providing isolated protein powder prepared by euphausia superba powder. A method comprises the following operation steps that the euphausia superba powder is degreased by ethanol, and then sequentially subjected to acid treatment, mineral substance removal, alkali treatment, protein dissolving, isoelectric point protein deposition, protein washing with distilled water, fluorine and salt removal and the like; low-fat, low-fluorine and low-salt euphausia isolated protein wet residue is obtained; the distilled water is added to the isolated protein wet residue; a pH (potential of hydrogen) value of a protein solution is adjusted to be neutral; an isolated protein solution is obtained; the isolated protein solution is subjected to spray drying; and then the euphausia superba isolated protein powder is obtained. Raw materials adopted by the method are rich, easy to obtain and high in protein content; the method is simple in preparation technology step, low in equipment investment, high in product yield and environmental-pollution-free, and is suitable for industrial production; the protein content in the euphausia superba isolated protein powder is greater than 90%; the fluorine content is less than 6mg / kg; the ash content is less than 5%; no lipid is remained; and the isolated protein powder is low-fat, low-fluorine and low-salt protein powder, and has the characteristic of forming heat-reversible protein gel.
Owner:OCEAN UNIV OF CHINA
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