53 results about "Pravastatin Sodium" patented technology

The invention provides a pravastatin sodium compound and a novel preparation method thereof. The method comprises the following steps of: (1) performing absorption and ion exchange on pravastatin sodium by using strongly acidic ion exchange resin; (2) eluting by using sodium carbonate or sodium bicarbonate aqueous solution at the concentration of 0.1 to 2 percent; and (3) separating and purifyingthe elution mother liquor by using a chromatographic column, collecting the eluted solution, washing by using water, drying by using a solid drying agent, concentrating under reduced pressure, evaporating to remove the eluted solution and obtaining a pravastatin sodium pure product. According to the high-purity pravastatin sodium compound prepared by the refining method, the purity and the content of the pravastatin sodium are increased greatly, the product quality of the preparation is improved, the toxic and side effects are reduced and the clinic medication safety is ensured; the method issimple in technology, low in cost and high in yield rate and is suitable for industrial production.

A process for the isolation or purification of pravastatin or a pharmacologically acceptable salt thereof comprising decomposing impurities using an inorganic acid, optionally in combination with an inorganic base.

The present invention relates to a crystal form of Pravastatin Na, and a preparation method and application thereof. The crystal form is named as a U crystal form. In an X-ray powder diffraction pattern, diffraction angle of 20 degrees, infrared spectrum and endothermic peak in the curve characteristic of a differential scanning calorimeter are defined. The Pravastatin Na in any forms is dissolved in an acid amide solvent to form a solution, the temperature is preferably 30 to 90 DEG C, and the mass ratio of the acid amide solvent to the Pravastatin Na is preferably 3 to 7:1; a dissolving agent is added in the Pravastatin Na solution, the mass of the dissolving agent is 3 to 15 times of that of the solvent, and then a suspension is formed; the suspension is separated and dried, and the U crystal form of the Pravastatin Na is obtained. Through the XRD pattern and the photographs of a scanning electron microscope, it is confirmed that the product has the advantages of high crystallinity, large crystal size, smooth crystal surface and high filtering speed, and the filtering time of crystal mush with the same density and same volume can be saved by more than one half. The U-form Pravastatin Na crystal as a medicine composite has the purpose of treating atherosclerosis or hypercholesterolemia.

The invention provides a pravastatin sodium tablet as well as application and a preparation method thereof. The pravastatin sodium tablet contains pravastatin sodium, mannitol as filler, a basifier, a caking agent and a lubricating agent. The pravastatin sodium tablet is prepared by using a direct tablet compressing method, has higher stability and is beneficial to the storage and the transportation of medicines.