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Solid preparation of sodium aspirin and sodium pravastatin medicinal composition

A technology of pravastatin sodium and aspirin sodium, which is applied in the field of aspirin sodium pravastatin sodium pharmaceutical composition solid preparation and aspirin sodium pravastatin sodium compound preparation, can solve the problem of poor liposome stability and encapsulation rate, etc. problems, to achieve the effect of improving bioavailability, high encapsulation efficiency, and prolonging cycle time

Inactive Publication Date: 2011-10-05
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new type medicine called Liposome Tablets (LUTS), consisting mainly two drugs: Aspirin Na or Pravastatin Sodium was developed that had good results but avoided problems with each other's medications separately. It also made its way into pharmaceutical products like Lutazolid® capsules without any issues such as poor solubility caused by water-solvable polymers used during manufacturing processes. Overall these improvements led to increased efficacy over existing treatments while reducing their negative impact on patients who took them regularly due to factors like gastric acidity.

Problems solved by technology

The patent text discusses a new formulation of a combination drug containing aspirin sodium and pravastatin sodium. The technical problem addressed in the patent is to improve the drug's main content and encapsulation rate, as well as its absorption in the stomach and bioavailability in the body.

Method used

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  • Solid preparation of sodium aspirin and sodium pravastatin medicinal composition
  • Solid preparation of sodium aspirin and sodium pravastatin medicinal composition
  • Solid preparation of sodium aspirin and sodium pravastatin medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of Aspirin Sodium Pravastatin Sodium Liposome Tablets

[0052] Prescription (1000 tablets)

[0053]

[0054]

[0055] Preparation Process

[0056] (1) 300g of hydrogenated soybean lecithin, 80g of cholesterol and 150g of poloxamer 188 are dissolved in 10000ml of a volume ratio of 1:3 in the mixed solvent of chloroform and n-butanol to obtain lipid solution;

[0057] (2) Place the above-mentioned lipid solution in a pear-shaped bottle, and remove the mixed solvent by rotary evaporation in a constant temperature water bath at 55° C. to form a uniform lipid film;

[0058] (3) Disperse 20 g of aspirin sodium and 81 g of pravastatin sodium in 900 ml of water, add it to a pear-shaped bottle and shake gently, so that the lipid film is eluted and dispersed in a hydration medium for dissolution to obtain a liposome suspension;

[0059] (4) Place the above-mentioned suspension in an ultrasonic instrument and sonicate to a translucent colloidal soluti...

Embodiment 2

[0064] Example 2 Preparation of Aspirin Sodium Pravastatin Sodium Liposome Tablets

[0065] Prescription (1000 tablets)

[0066]

[0067]

[0068] Preparation Process

[0069] (1) 600g of hydrogenated soybean lecithin, 200g of cholesterol and 300g of poloxamer 188 are dissolved in 20000ml of a volume ratio of 1:3 in a mixed solvent of chloroform and n-butanol to obtain a lipid solution;

[0070] (2) Place the above-mentioned lipid solution in a pear-shaped bottle, and remove the mixed solvent by rotary evaporation in a constant temperature water bath at 45° C. to form a uniform lipid film;

[0071] (3) Disperse 20 g of aspirin sodium and 81 g of pravastatin sodium in 900 ml of water, add it to a pear-shaped bottle and shake gently, so that the lipid film is eluted and dispersed in a hydration medium for dissolution to obtain a liposome suspension;

[0072] (4) Place the above-mentioned suspension in an ultrasonic instrument and sonicate to a translucent colloidal solut...

Embodiment 3

[0077] Example 3 Preparation of Aspirin Sodium Pravastatin Sodium Liposome Tablets

[0078] Prescription (1000 tablets)

[0079]

[0080]

[0081] Preparation Process

[0082] (1) 450g hydrogenated soybean lecithin, 140g cholesterol and 220g poloxamer 188 are dissolved in 15000ml volume ratio is in the mixed solvent of chloroform and n-butanol of 1: 3, obtain lipid solution;

[0083] (2) Place the above-mentioned lipid solution in a pear-shaped bottle, and remove the mixed solvent by rotary evaporation in a constant temperature water bath at 50° C. to form a uniform lipid film;

[0084] (3) Disperse 40 g of aspirin sodium and 81 g of pravastatin sodium in 1300 ml of water, add to a pear-shaped bottle and shake gently, so that the lipid film is eluted and dispersed in a hydration medium for dissolving to obtain a liposome suspension;

[0085] (4) Place the above-mentioned suspension in an ultrasonic instrument and sonicate to a translucent colloidal solution;

[0086] ...

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Abstract

The invention discloses a liposome preparation of sodium aspirin and sodium pravastatin. The liposome is mainly prepared from the following components in part by weight: 20 to 40 parts of sodium aspirin, 81 parts of sodium pravastatin, 200 to 1,000 parts of hydrogenated soybean phosphatidylcholine, 50 to 500 parts of cholesterol and 100 to 400 parts of poloxamer 188. The invention also discloses a solid preparation of a sodium aspirin and sodium pravastatin medicinal composition, which is prepared from the liposome preparation of sodium aspirin and sodium pravastatin, and other excipients usually used pharmaceutically. The quality of the preparation is improved and the toxic and side effects are reduced.

Description

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Claims

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Application Information

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Owner HAINAN YONGTIAN PHARMA INST
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