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30 results about "Postoperative risk" patented technology
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Lasso-based esophageal squamous cell carcinoma patient risk prediction column diagram model establishment method
ActiveCN112635056AFeature variable foundImprove performanceMedical data miningHealth-index calculationOncologyRisk groups
The invention provides a Lasso-based esophageal squamous cell carcinoma patient risk prediction column diagram model establishment method, which is used for evaluating the postoperative survival risk of esophageal squamous cell carcinoma patients. The method comprises the following steps: firstly, collecting clinical data of esophageal squamous cell carcinoma patients, analyzing the clinical data by utilizing single-factor Cox, Lasso and multi-factor Cox regression analysis methods to obtain important characteristic variables, and establishing probability prediction models with different characteristic dimensions; secondly, selecting a probability prediction model with better performance and establishing a postoperative risk prediction column diagram model of the esophageal squamous cell carcinoma patient; and finally, dividing the patients into a high-risk group and a low-risk group according to the postoperative risk prediction column diagram model of the esophageal squamous cell carcinoma patients, and verifying the reliability and effectiveness of model classification through a KM survival curve analysis method. According to the method, the postoperative survival risk of the esophageal squamous cell carcinoma patient can be accurately predicted, reference is better provided for treatment of the esophageal squamous cell carcinoma patient, and meanwhile the risk prediction cost is reduced.
Owner:ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
Method for establishing hepatocellular carcinoma postoperative risk assessment model
PendingCN112331343AGuide individualized treatmentEase of evaluationHealth-index calculationMicrobiological testing/measurementTumour metabolismParanasal Sinus Carcinoma
The invention discloses a method for establishing a hepatocellular carcinoma postoperative risk assessment model, the model comprises 10 metabolism-related gene calculation items, the sum of the expression level of each gene weighted by a corresponding coefficient is used as a risk score, the risk of poor postoperative overall survival of a patient can be judged, and tumor metabolism characteristics are reflected.
Owner:JUSBIO SCI SHANGHAI CO LTD
Medical nanofiber reinforced hydrophilic composite material as well as preparation method and application thereof
The invention discloses a medical nanofiber reinforced hydrophilic composite material as well as a preparation method and application thereof. The composite material is prepared from a hydrophilic basis material and nano staple fibers, wherein the nano staple fibers are maintained in crystal morphology and are uniformly dispersed in the hydrophilic basis material; the mass percent of the nano staple fibers in the composite material is 1 to 30 percent; the nano staple fibers have the diameters of 200nm to 800nm and the lengths of 10mu m to 100mu m; according to the preparation method of the medical nanofiber reinforced composite material, which is provided by the invention, the technological design is peculiar; the nano staple fibers are uniformly dispersed in the basis material by utilizing the solubility difference of the basis material and the nano staple fibers; the multicellular spongy composite material is obtained by adopting a freeze drying method; the composite material keeps the respective advantages of two materials; defects are complementary; the composite material which is excellent in mechanical performance, good in biocompatibility and good in biodegradability is obtained, and the medical nanofiber reinforced hydrophilic composite material is moderate in degradation cycle, cannot cause a postoperative inflammation and the postoperative risk of adhesion, is more suitable for clinical demand.
Owner:SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
Congenital heart disease postoperative risk visual evaluation method based on patient similarity
PendingCN114203299AAccurate descriptionGood explainabilityMedical data miningHealth-index calculationDiseaseFeature extraction
The invention discloses a patient similarity-based congenital heart disease postoperative risk visual evaluation method. The method comprises the following steps: constructing a congenital heart disease ontology according to multi-source heterogeneous disease knowledge; performing multi-dimensional feature extraction on the ultrasonic report text of the historical congenital heart disease patient to obtain standard ultrasonic text features; based on the standard ultrasonic text features, calculating the similarity distance of the ultrasonic text features of the congenital heart disease patient; on the basis of the similarity distance of the ultrasonic text features, fusing preoperative and intraoperative information of the congenital heart disease patients, calculating a similarity distance matrix among the congenital heart disease patients, and generating a congenital heart disease patient map; according to the map of the congenital heart disease patient, a similar patient group is recommended for the target patient through a similarity algorithm, and clinical personnel are assisted in conducting postoperative risk assessment on the target patient through the postoperative risk factors of the similar patient group. The assessment method can assist doctors in assessing the physiological and pathological conditions of the patient and enhance monitoring and management in the perioperative period.
Owner:ZHEJIANG UNIV
Net bag device for treating ACL tibial avulsion fracture
InactiveCN105147373AReduce the risk of adverse postoperativeReduce the difficulty of surgerySurgeryTibiaBone tunnel
The invention provides a net bag device for treating the ACL tibial avulsion fracture. The net bag device comprises a net bag-shaped fixing structure, wherein three groups of traction fixing lines are fixedly connected onto the periphery of the net bag-shaped fixing structure at least; the net bag-shaped fixing structure is used for covering a fracture part; and multiple groups of traction fixing lines extend out from bone tunnels arranged on the tibia and then are fixed together, so that the net bag-shaped fixing structure can tightly press the avulsed ligament on the tibia. According to the net bag device for treating the ACL tibial avulsion fracture, provided by the invention, the net bag device directly covers the ligament avulsion part, so that injuries to the ligament and joints are not caused, and adverse postoperative risks are reduced; and in addition, by adopting the net bag device provided by the invention, the operation difficulty and operation cost are reduced greatly, and a secondary operation for taking out an implant is not required since the net bag device is made of ultrahigh molecular weight polyethylene suture lines.
Owner:SHANGHAI KINETIC MEDICAL
Method for laser engraving of nasal prosthesis
Owner:SHENZHEN HANS 3D TECH
Type B aortic dissection postoperative risk prediction method and device, and electronic device
The embodiments of the invention provide a type B aortic dissection postoperative risk prediction method and device, and an electronic device, and relates to the technical field of medical images. Thetype B aortic dissection postoperative risk prediction method comprises the steps that firstly, a plurality of cases of preoperative three-dimensional angiography images are obtained, and all cases of the three-dimensional angiography images are pretreated to obtain a to-be-treated data set, wherein the to-be-treated data set comprises blood vessel true lumen information and blood vessel false lumen information; then the blood vessel true lumen information and the blood vessel false lumen information are subjected to vector analysis to obtain various image omics feature information, and the various image omics feature information is subjected to dimensionality reduction treatment and linear fitting to obtain risk factor variables; and finally, a risk predicting model is constructed according to the risk factor variables and a preset clinical lesion type. In this way, the risk probability of postoperative complications can be obtained, and thus patient safety is ensured.
Owner:HUIYING MEDICAL TECH (BEIJING) CO LTD
Tibia trial mold operation tool system with multiple verifications
ActiveCN111839823AGuarantee stabilityGuaranteed accuracyJoint implantsSkullPhysical medicine and rehabilitationPhysical therapy
The invention discloses a tibia trial mold operation tool system with multiple verifications, which comprises tibial plateau substrates, a gasket test mold is arranged at the upper end of the tibial plateau base plate; the gasket test mold is provided with a thickening cushion block; the tibial plateau base plate is clamped and matched with the gasket test mold; a gasket test mold cushion block isclamped and matched with the tibia gasket test mold; the invention discloses the tibia trial mold operation tool system with multiple verifications, the tibial plateau base plate is matched with thetibial gasket test mold and the gasket test mold cushion block, so that the mounting position and size of the knee joint prosthesis can be verified for three times after the tibial plateau osteotomy,the tibial plateau wing-shaped groove osteotomy and the tibial support prosthesis are mounted, the stability and mobility of the knee joint and whether the tension of the lateral ligament is proper ornot, balance, tightness and the like are determined, the operation accuracy is ensured, the operation success rate is increased, the postoperative risk is reduced, the number of surgical instrumentsis reduced, and the cost is reduced.
Owner:天衍医疗器材有限公司
Impact wave cardiac valve interventional treatment delivery system
PendingCN110368061AEasy to open and closeReduce riskSurgical navigation systemsProsthetic valveEngineering
The invention discloses an impact wave cardiac valve interventional treatment delivery system. The delivery system comprises an outer braided tube of a hollow structure, an inner tube of a hollow structure and a conducting electrode cable, wherein the inner tube is located in the outer braided tube, and a prefabricated channel is formed between the inner tube and the outer braided tube; the conducting electrode cable extends in the prefabricated channel and is used for conducting voltage / current pulses. Through the delivery system, an impact device for treating cardiac valve calcification transmits energy and transforms the energy to an impact wave transmitter, valvular stenosis and reflux stiff valve leaflets or valvular annuli are softened, the opening and closing states of the valve leaflets during work are improved, the treatment effect is achieved, and the intraoperative and postoperative risks of artificial valve implantation can be avoided. The system can be combined with existing operative treatment, the problem is solved that in the operative process, due to serious valve calcification, a cardiac valve cannot be precisely placed, the risks are effectively avoided that in the operative process, the artificial valve is difficult to position and fix, and the artificial valve is improperly released and difficultly taken out, and perivalvular leakage can be reduced.
Owner:PEIJIA MEDICAL TECH SUZHOU
Disposable eye cleaning wet wipe
InactiveCN107157809ASolve full problemsRehabilitation after surgeryAntibacterial agentsCosmetic preparationsL-AspartateWet wipe
The invention discloses a disposable eye cleaning wet wipe. The disposable eye cleaning wet wipe comprises a base material and an immersion liquid and is characterized in that the immersion liquid is prepared from the following raw materials in percentage by mass: 3-5% of medical tea tree essential oil, 3-5% of iodophor and 0.5-3.0g / L of sodium L-aspartate, 6-aminocaproic acid and chlorhexidine gluconate. The disposable eye cleaning wet wipe disclosed by the invention has the advantages that the medical tea tree essential oil is added into the immersion liquid, so that the problem of mites at eyes is solved; meanwhile, the disposable eye cleaning wet wipe also can be used for cleaning and disinfecting before and after an operation of the eyes, the mites are eliminated, and escherichia coli, staphylococcus aureus, candida albicans and the like can be finitely inhibited; and the disposable eye cleaning wet wipe is more beneficial to postoperative rehabilitation of a patient, reduces the risk of postoperative infection and has the characteristics of safety and health, low postoperative risk as well as benefit on rehabilitation of the patient.
Owner:彭亮宇
Heart disease postoperative real-time monitoring and early warning equipment
InactiveCN112735086AReduce dependenceReduce postoperative riskAlarmsEmergency medicineData acquisition module
The invention discloses heart disease post-operation real-time monitoring and early warning equipment which is internally provided with a post-operation monitoring and early warning system and a post-operation rehabilitation guidance system, wherein the postoperative monitoring and early warning system is composed of a registration and login module, a sign data acquisition module, a sign data monitoring module, a sign data analysis module, a sign early warning module and a wireless transmission module, and the postoperative rehabilitation guidance system is composed of a postoperative guidance module, a rehabilitation supervision module and a review diagnosis module. According to the monitoring and early warning equipment, various physical sign data of a patient are detected through the postoperative monitoring and early warning system, real-time remote early warning can be achieved, so that postoperative risks are reduced, meanwhile, postoperative rehabilitation treatment is guided and supervised through the postoperative rehabilitation guiding system, and the rehabilitation supervision module is provided with a diet assisting unit and a medicine assisting unit; auxiliary guidance is carried out on early-stage, middle-stage and later-stage diet of a patient, and the medicine auxiliary unit assists medicine treatment according to physical sign data of the patient and helps the patient to reduce medicine dependence.
Owner:南京鼎世医疗器械有限公司
Method and kit for performing profiling of endarterectomy patients
InactiveUS8906613B2Reduce mortalityReduce riskMicrobiological testing/measurementCatheterPostoperative riskPlaque Tissue
Owner:FOLKERSEN LASSE +4
Postoperative risk prediction natural language data enhancement model and method
ActiveCN114334159AAchieve the purpose of integrationMedical data miningSemantic analysisData setMedicine
The invention discloses a postoperative risk prediction natural language data enhancement model and method, and the method comprises the steps: enabling natural language data to obtain a pre-training model MedBERT through the training of a data set in the medical field, and converting the pre-training model MedBERT into a vector through the mode; discrete variables in table data are also converted into vectors in an entity embedding mode, and for different types of data of the table data and the discrete variables, a multi-head self-attention mode is selected to fuse the discrete variables and the vectors. The attention mechanism algorithm is used for extracting the relevance between the features and screening out important features for prediction, so that key information in the natural language data can be associated with key information of the table data, and the purpose of fusing multiple types of information is achieved; according to the method, the natural language data is brought into the task of postoperative risk prediction for the first time.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV +1
Quick-mounting biliary tract internal drainage stent for treatment
ActiveCN112274306AQuick assembly positioningShorten operation timeStentsSurgeryBiliary tractEngineering
The invention discloses a quick-mounting biliary tract internal drainage stent for treatment, and belongs to the technical field of medical instruments. The stent comprises a quick-mounting mechanism,a guide wire mechanism sleeves one side of the quick-mounting mechanism, an outer support mechanism is fixedly connected to one side of the guide wire mechanism, an inner support mechanism is fixedlyconnected to an inner cavity of the outer support mechanism, the outer supporting mechanism comprises an outer supporting frame, the outer supporting frame is formed by winding and weaving first memory metal wires, second memory metal wires and electric heating metal wires, an inner cavity of the outer supporting frame is in transmission connection with the inner supporting mechanism, and one side of the outer supporting frame is fixedly connected with a balance weight pad. According to the invention, through the arrangement of an inner air bag, quick mounting and positioning can be carried out through the matching of the inner air bag, an inner connecting cable and an air valve, and postoperative suture is not required to be carried out after the memory metal of the outer support frame is heated and expanded for limiting supporting, so that the operation time is remarkably shortened, the postoperative risk caused by overlong operation time is reduced, and the operation safety is improved.
Owner:SUZHOU FRANKENMAN MEDICAL EQUIP
Blood vessel puncture mouth I-shaped blanker for interventional medicine and manufacturing method thereof
The invention discloses a blood vessel puncture mouth I-shaped blanker for interventional medicine and a manufacturing method thereof. The blanker is of an I-shaped structure shown in figure (1), andis composed of a blanker body (1), a blanker inner sheath (2), a blanker outer sheath (4), a control disc (3), a control disc (5), an inner core pipe (6), an inner core pipe (7) and a connecting line(8). The I-shaped blanker is made from biodegradable macromolecular polymers, the inner wall and the outer wall of a blood vessel are clamped through an inner buckling disc and an outer buckling discwith high-elasticity memory performance, the blanker can be completely degraded within 4-6 weeks, and regeneration and restoration of the walls of the blood vessel are benefited. The blood vessel puncture mouth I-shaped blanker is easy and convenient to operate, a blood vessel puncture mouth can be effectively closed, postoperative risks can be effectively reduced, and the pain and the strength ofmedical care are relieved.
Owner:深圳麦普奇医疗科技有限公司
Vertebral prosthesis
The invention provides a vertebral prosthesis. The vertebral prosthesis includes a body for supporting a human vertebral body, and a protective casing connected with the body; a lumen for accommodating medulla spinalis is formed in the protective casing. The body of the vertebral prosthesis is used for supporting the human vertebral body after osteotomy, the protective casing wraps the medulla spinalis to replace a vertebral arch and other tissues after osteotomy, and the lumen is equivalent to the canalis vertebralis of the human vertebral body; therefore, the role of protecting the medulla spinalis is played to prevent other tissues from growing into and oppressing the medulla spinalis and reduce postoperative risks.
Owner:BEIJING AKEC MEDICAL
A method of laser engraving nasal prosthesis
Owner:SHENZHEN HANS 3D TECH
Wearing device for infection monitoring after biliary drainage
ActiveCN110038173BReduce postoperative riskAnalysing gaseous mixturesIntravenous devicesBiliary drainsBiliary tract
Owner:CHONGQING CANCER INST
Clamping and locking medical instrument and use method thereof
PendingCN114028028AQuick gripHigh precisionAnnuloplasty ringsInstruments for stereotaxic surgeryHuman bodyApparatus instruments
Owner:SHANGHAI HUIHE HEALTHCARE TECH CO LTD
Wearing device for infection monitoring after biliary drainage
ActiveCN110038173AReduce postoperative riskImplement infection monitoringAnalysing gaseous mixturesIntravenous devicesBiliary tractEngineering
Owner:CHONGQING CANCER INST
Vertebral prosthesis
The invention provides a vertebral prosthesis. The vertebral prosthesis includes a body for supporting a human vertebral body, and a protective casing connected with the body; a lumen for accommodating medulla spinalis is formed in the protective casing. The body of the vertebral prosthesis is used for supporting the human vertebral body after osteotomy, the protective casing wraps the medulla spinalis to replace a vertebral arch and other tissues after osteotomy, and the lumen is equivalent to the canalis vertebralis of the human vertebral body; therefore, the role of protecting the medulla spinalis is played to prevent other tissues from growing into and oppressing the medulla spinalis and reduce postoperative risks.
Owner:BEIJING AKEC MEDICAL
Postoperative end risk early warning and related equipment based on multimodal monitoring information
ActiveCN113171059BSolve the problem of whiteningHigh speedSensorsNervous system evaluationEmergency medicineStatistical process control
Owner:BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Active closed drainage mechanism for thoracic and abdominal cavity surgery
ActiveCN112472888AImprove practicalityAvoid BacteriuriaMedical devicesSuction devicesSurgical operationPeristaltic pump
The invention discloses an active closed drainage mechanism for thoracic and abdominal cavity surgery, and particularly relates to the field of medical treatment. The active closed drainage mechanismcomprises a drainage storage bag, a portable hanging rope, a drainage needle tube and an active drainage device; a driving mechanism is fixedly installed on the surface of the active drainage device,and the top face of the drainage storage bag and the bottom face of the active drainage device are detachably installed; the liquid inlet end of the active drainage device is connected with one end ofthe drainage needle tube, the drainage storage bag comprises a liquid storage bag body, a release valve tube is arranged at the bottom end of the liquid storage bag body, an installation plate is arranged on the top face of the liquid storage bag body, and a liquid inlet tube opening is formed in the surface of the installation plate. According to the scheme, the medical drainage mechanism adoptsan active drainage mode, the active drainage device is controlled to work through transmission driving of the driving mechanism, and exudation, hydrops and the like in the body of a patient or in thedeep part of a local operation are guided out of the body through peristaltic pumping; bacteria urine infection and other postoperative risks caused by long-time retention of liquid such as hydrops in the body of a patient are avoided, and the practicability of the drainage mechanism is improved.
Owner:HANGZHOU VALUEDMED
A quick-loading biliary drainage stent for treatment
ActiveCN112274306BQuick assembly positioningShorten operation timeStentsSurgeryBiliary tractEngineering
Owner:SUZHOU FRANKENMAN MEDICAL EQUIP
Postoperative END risk early warning and related equipment for multi-modal monitoring information
ActiveCN113171059ASolve the problem of whiteningHigh speedSensorsNervous system evaluationEmergency medicineFeature data
The invention relates to postoperative END risk early warning and related equipment for multi-modal monitoring information. The equipment comprises a memory and a processor. The processor is used for executing the following operations: acquiring clinical data of a to-be-tested user in a current time period; inputting the clinical data into a depth auto-encoder based on a convolution theory to obtain feature data corresponding to the clinical data; and acquiring a statistical value of the clinical data by using a statistical process control method, comparing the statistical value of the clinical data with an early warning threshold value corresponding to the current time period, and determining postoperative END risk early warning of the next time period according to a comparison result. According to the method and the device, the postoperative END early warning is updated in real time.
Owner:BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
A natural language data enhancement model and method for postoperative risk prediction
ActiveCN114334159BAchieve the purpose of integrationMedical data miningHealth-index calculationData setMedicine
The invention discloses a natural language data enhancement model and method for postoperative risk prediction. The natural language data is converted into a vector through the pre-training model MedBERT obtained under the training of the data set in the medical field. The discrete variables in the tabular data are also converted into vectors by means of entity embedding, and for the two different types of data, the multi-head self-attention method is selected to fuse them. The attention mechanism algorithm extracts the correlation between features, and screens out important features for prediction, so that the key information in the natural language data can be associated with the key information in the tabular data, and the purpose of multi-type information fusion is achieved. For the first time, the invention incorporates natural language data into the task of postoperative risk prediction.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV +1
Method and Kit for Performing Profiling of Endarterectomy Patients
InactiveUS20130210636A1Reduce mortalityReduce riskMicrobiological testing/measurementLibrary member identificationCvd riskPlaque Tissue
A method of profiling endarterectomy patients for determining one or more post-operative risks includes steps comprising:(a) obtaining a set of parameters which describe the patient, the set of parameters including at least one of: age of patient, E; smoking habits of patient, S; serum cholesterol concentration of patient, C; diabetes status of patient, D; blood pressure of patient, P;(b) obtaining one or more samples of plaque tissue from endarterectomy treatment of the patient;(c) isolating genetic material from the one or more samples of plaque tissue;(d) determining genetic expression activities of a plurality of genes identified in the genetic material; and(e) computing from the set of parameters in combination with the genetic expression activities one or more post-operative risks indicative of potential events to which the patient is susceptible as a consequence of the endarterectomy treatment.
Owner:FOLKERSEN LASSE +4
CD47 and TIGIT double-target-point-based lung squamous cell carcinoma patient prognosis evaluation system and application thereof
PendingCN114672567AMicrobiological testing/measurementBiological material analysisLung squamous cell carcinomaOncology
The invention discloses a lung squamous cell carcinoma patient prognosis evaluation system based on CD47 and TIGIT double targets and application of the lung squamous cell carcinoma patient prognosis evaluation system. The invention also discloses an application of the substance for detecting the expression quantity of CD47 and TIGIT in any one of the following (A1)-(A6): (A1) preparing a product for prognosis evaluation of a lung squamous cell carcinoma patient; (A2) preparing a product for predicting the postoperative risk of the lung squamous cell carcinoma patient; (A3) preparing a product for predicting the total postoperative lifetime of the lung squamous cell carcinoma patient; (A4) prognosis evaluation of lung squamous cell carcinoma patients; (A5) predicting the postoperative risk of the lung squamous cell carcinoma patient; and (A6) predicting the total postoperative lifetime of the lung squamous cell carcinoma patient. According to the invention, a lung squamous cell carcinoma prognosis evaluation system based on CD47 and TIGIT double targets is constructed, and verification is carried out in a large-scale queue. Meanwhile, CD47 and TIGIT are potential immunotherapy targets for lung squamous cell carcinoma, and clear expression quantity provides a new method for predicting the curative effect of immunotherapy in the future while prognosis is evaluated.
Owner:CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
ICU discrimination system for postoperative infection of neurosurgical patients
PendingCN113241172AReduce postoperative riskSimplify medical proceduresMedical communicationMedical automated diagnosisPatient needMedical equipment
The invention discloses an ICU discrimination system for postoperative infection of neurosurgical patients, wherein the ICU discrimination system is divided into four layers including a physical layer, a transmission layer, a platform layer and an application layer, the physical layer is a medical device arranged in a hospital and used for collecting physical sign data, the transmission layer is a hospital local area network, and the platform layer is composed of a graph database and an analyzer; the graph database is a container for storing neurosurgery patient information and neurosurgery related disease information, and the analyzer is used for taking the graph database as a training set, building a prediction model and inputting newly generated patient data and historical data of a patient into the model at the same time so as to judge whether to enter an ICU or not; and the application layer is a visual terminal and comprises visualization of a graph database and display of ICU discrimination results. A problem that the neurosurgery patient needs to spend too many medical resources after operation is solved, so that the medical process is simplified, the postoperative risk of the patient is reduced, and time is saved.
Owner:EDGE INTELLIGENCE RES INST NANJING CO LTD
Postoperative risk prediction method and related model training method, device and equipment
PendingCN114864089AAvoid subjective influenceImprove accuracyHealth-index calculationCharacter and pattern recognitionPhysical medicine and rehabilitationReceptor
The invention discloses a postoperative risk prediction method and a related model training method, device and equipment, and the method comprises the steps: obtaining target object information of a target object, the target object comprises a target organ, a donor of the target organ and a receptor of the target organ, and the target object information comprises medical information; and based on the target object information of the target object, predicting the risk related to the target organ after organ transplantation of the receptor by using the prediction model, and obtaining a prediction result. According to the scheme, the prediction accuracy can be improved.
Owner:SHANGHAI SENSETIME INTELLIGENT TECH CO LTD
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