52 results about "Piperacillin Sodium" patented technology

The invention provides a stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium and the preparation method thereof. The drug compound consists of piperacillin sodium, Beta-lactamases inhibitors and pH-value regulators with the weight proportion of 1 to 100:1:0.001 to 2. Diluted and delivered in any proportion with conventional clinical transfusions, the drug compound can have a stable piperacillin sodium content, dissolve rapidly, generate no crystallization or degradation products and receive no effect from the temperature. The preparation method of the stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium has simple preparing method and high efficiency and is fit for a large-scale industrial production.

The invention relates to suspensoid powder injection of a piperacillin sodium sulbactam medicine composition prepared by applying an emulsification suspensoid technology and freeze drying. The invention further relates to a novel application of the suspensoid powder injection in preparing a medicine treating the infection of the oral cavity.

A blood cell analyzer diluent and a hemolytic agent, are characterized in that one litre diluent is provided with 12.0-4.0g of sodium chloride, 2.0-10.0g of sodium sulfate, 0.8-0.5g of 1,3,2-methylol urea, 0.2-0.5g of copper sulfite, 3.0-8.0g of EDTA-2Na, 0.2-0.7g of Piperacillin Sodium, a borate buffering liquid toning the ph value to 7.2-7.8, and the balance is water; one litre hemolytic agent is provided with 0.8-5.0g of potassium chloride, 0-60.0g of dodecyl trimethyl ammonium chloride, 14.0-0g of octadecyl trimethyl ammonium bromide, 6.0-10.0ml of isopropanol, carbonate or alcaine buffering liquid toning the ph value to 7.2-7.8, and the balance is water. The inventive reagent can form stable hemoglobin derivatives, and the absorption spectrum curves are similar when lambada is 540nm, lambada is 504nm, which can satisfy the clinical inspection requirement; the reagent does not contain cyanide, azide, and has non-toxicity, which can effective improve working atmosphere of operating staff, and can reduce harm of toxicant to personal health.

The invention provides a method for detecting related substances in piperacillin sodium and sulbactum sodium for injection. The method adopts an octadecyl silane bonded silica-gel chromatographic column to carry out gradient elution so as to rapidly and precisely complete the detection on related substances in piperacillin sodium and sulbactum sodium. In the obtained chromatogram, the main related substance (2S)-2-amino-3-methyl-3-sulfinobutyric acid and piperacillin penicilloic acid are well separated, piperacillin and sulbactum are also well separated from other related substances, and the separation degree is more than 1.5. The degradation researches and methodology on piperacillin sodium and sulbactum sodium show that the provided method has a stability indicating function, and thus the detection method can be used to control the limits of impurities in piperacillin sodium and sulbactum sodium, and can also be used to control the quality of piperacillin sodium and sulbactum sodium for injection. The method has the advantages of convenient operation and low cost, and has a good economic profit and promotion prospect.

The present invention relates to a compound injection preparation formed from probenecid sodium and benzylpenicillin antibiotics, belonging to the field of chemical pharmaceutical technology. The benzylpenicillin antibiotics include amoxicillin sodium and piperacillin sodium. The amoxicillin sodium and piperacillin sodium are mixed according to ratio of 1:3 and 1:5 through a conventional preparation process.

The invention discloses a novel high performance liquid chromatography (HPLC) method, which can detect the content and relevant impurities of two single components in the compound preparation of piperacillin sodium and sulbactam sodium simultaneously, and the two components do not interfere and influence each other. The method has the advantages of simple operation, strong specificity, high sensitivity, wide linear range, and high stability, and can be used for detecting compound preparations and materials.

The invention relates to a preparation method of piperacillin sodium sulbactam sodium for injection. The preparation method comprises the following steps of: moving and mixing the piperacillin sodium and the sulbactam sodium in a sealed container in various directions at a weight ratio of 4:1; discharging the powder after physically mixing the powder; weighing and filling the powder into a barrel; carrying out subsequent treatment to obtain the piperacillin sodium sulbactam sodium for injection. According to the preparation method of the piperacillin sodium sulbactam sodium for injection, only the piperacillin sodium and the sulbactam sodium are selected as raw materials without introducing other novel substances, so that on one hand, the content of main ingredient of the medicament is high, on the other hand, the introduced impurities including related substances and the like are reduced. Moreover, the whole process is strictly controlled, so that the prepared piperacillin sodium sulbactam sodium for injection is low in moisture content, less in visible foreign substances and less in in-soluble particles, and therefore, the anaphylactic reaction during the injection is effectively reduced, and the medicament use is safer.

The invention relates to a powder mixing technology for a compound antibiotic. The compound antibiotic is obtained by cold drying after uniform mixing of antibiotic A and antibiotic B in advance, wherein the antibiotic A is mezlocillin sodium, amoxicillin sodium, cefoperazone sodium, and piperacillin sodium, and the antibiotic B is sulbactam sodium. According to the powder mixing technology, organic solvent is omitted, the environment is less polluted, the freeze-drying technology has stable yield, and the cost is low; the freeze-drying mixed powder has good uniformity, fast dissolution rate, and stable chemical quality, so that the powder mixing technology is applicable to preparation of various of compound antibiotics, and is suitable for mass production.

The invention discloses a medicine composition of piperacillin sodium and tazobactam sodium. Raw material medicine comprises piperacillin sodium micro powder and tazobactam sodium micro powder of d95 within the range of 120 micrometers to 180 micrometers. Experiments prove that the medicine composition is high in antimicrobial activity, good in redissolving performance and high in product safety.

The invention discloses a piperacillin sodium compound containing half water and a preparation method thereof. Each mole of piperacillin sodium contains a half mole of water. First, ampicillin trihydrate is reacted with 4-ethyl-2,3-dioxypiperazine formyl chloride to form piperacillin acid, then piperacillin acid is reacted with sodium acetate in a mixed solution of acetone and water, isopropanol is added dropwise, and crystallization, filtration and drying are conducted to obtain the piperacillin sodium compound containing half water. The piperacillin sodium compound containing half water hashigh fluidity, low hygroscopicity and impurity content, high thermodynamic stability and a wider application prospect.

The invention discloses a medicinal composition. The medicinal composition comprises piperacillin sodium and tazobactam sodium serving as raw material medicaments, and is characterized in that: the piperacillin sodium serving as the raw material medicament is prepared from piperacillin acid through ion exchange resin; and the tazobactam sodium serving as the raw material medicament is prepared from tazobactam acid through the ion exchange resin. Experiments prove that a preparation prepared from the medical composition has higher quality.

The invention discloses an automatic filling machine for piperacillin sodium and sulbactam sodium medicine powder used for injection. The automatic filling machine comprises an operating platform and a rotating device fixed on the operating platform. A round medicine bottle fixing tray is fixed on the rotating device. Grooves are formed in the periphery of the medicine bottle fixing tray, a supporting rod is fixed on the operating platform, and a fixing plate is fixed at the top of the supporting rod. A seal plate is movably connected with the bottom of the fixing plate. A stop block is fixed at the bottom of the fixed plate. Medicine placing boxes are fixed on the fixing plate, conduits are perpendicularly fixed on the seal plate, and a driving device is connected to the seal plate. The automatic filling machine for the piperacillin sodium and sulbactam sodium medicine powder used for the injection has the advantages of being simple in structure, small in occupied area, economical and practical.

The present invention addresses the main problem of providing a novel method for producing a freeze-dried preparation (combination drug) for injection that comprises tazobactam sodium and piperacillin sodium. An example of the production method according to the present invention is as follows. A method for producing a freeze-dried preparation for injection, said method being characterized by comprising: (a) a step for blowing carbon dioxide gas into an aqueous sodium hydroxide solution; and (b) a step for dissolving tazobactam and piperacillin in the solution obtained in step (a). According to the present invention, a freeze-dried preparation showing good defoaming performance after redissolution can be obtained.

The invention provides a method for detecting relevant substances in piperacillin sodium and sulbactam sodium for injection. According to the method, octadecylsilane bonded silica gel is adopted as filler and tetrabutyl ammonium hydroxide solution-acetonitrile is adopted as a moving phase for gradient elution, and measurement of the relevant substances in piperacillin sodium and sulbactam sodium is realized quickly and accurately.

The invention discloses a medicinal composition of piperacillin sodium and sulbactam sodium. The medicinal composition comprises the following components in parts by weight: 2-4 parts of piperacillin sodium and 1 part of sulbactam sodium with specific rotation being from +230 degrees to +235 degrees. The medicinal composition disclosed by the invention has the advantages that the sulbactam sodium with the specific rotation being from +230 degrees to +235 degrees is prepared by optimizing a preparation process of the sulbactam sodium; by optimization of the preparation process of the piperacillin sodium, the stability of the medicinal composition is favorably improved and the use is safer.