52 results about "Piperacillin Sodium" patented technology

The invention discloses a medicinal composition. The medicinal composition comprises piperacillin sodium and tazobactam sodium serving as raw material medicaments, and is characterized in that: the piperacillin sodium serving as the raw material medicament is prepared from piperacillin acid through ion exchange resin; and the tazobactam sodium serving as the raw material medicament is prepared from tazobactam acid through the ion exchange resin. Experiments prove that a preparation prepared from the medical composition has higher quality.

The invention provides a stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium and the preparation method thereof. The drug compound consists of piperacillin sodium, Beta-lactamases inhibitors and pH-value regulators with the weight proportion of 1 to 100:1:0.001 to 2. Diluted and delivered in any proportion with conventional clinical transfusions, the drug compound can have a stable piperacillin sodium content, dissolve rapidly, generate no crystallization or degradation products and receive no effect from the temperature. The preparation method of the stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium has simple preparing method and high efficiency and is fit for a large-scale industrial production.

The invention relates to an eutectic of Piperacillin sodium and Sulbactam sodium, a preparation method thereof, a pharmaceutical composition containing the eutectic and an application of the pharmaceutical composition on treating infection of super bacteria producing NDM-1 and other drug-resistance bacteria. The eutectic of the Piperacillin sodium and the Sulbactam sodium comprises diffraction angles of 14.24 DEG, 16.58 DEG, 16.79 DEG, 17.77 DEG, 19.20 DEG, 20.21 DEG, 20.39 DEG, 23.06 DEG, 27.86 DEG and 32.16 DEG represented by 2[theta] in an X-ray powder diffraction analysis spectra. The eutectic provided by the invention is excellent in solubility, low in hygroscopicity, relatively small in powder volume, high in purity, low in content of related substances, and easy to filter and dry during industrial production. A compound preparation prepared by the eutectic has obviously improved stability; not only is the shelf life of the products prolonged, but also the product safety is improved, thereby reducing potential adverse risks of the drugs and further protecting the health of patients.

The invention relates to suspensoid powder injection of a piperacillin sodium sulbactam medicine composition prepared by applying an emulsification suspensoid technology and freeze drying. The invention further relates to a novel application of the suspensoid powder injection in preparing a medicine treating the infection of the oral cavity.

The invention provides a piperacillin sodium and sulbactam sodium sterile powder-injection. The piperacillin sodium piperacillin sodium sterile powder-injection is prepared from piperacillin sodium, sulbactam sodium and a stabilizer. The stabilizer is composed of mycose, sodium pyrosulfite and glycine. The piperacillin sodium and sulbactam sodium sterile powder-injection comprises, by weight, 2-4 parts of the piperacillin sodium, 1 part of the sulbactam sodium, 20-40 parts of the mycose, 8-15 parts of the sodium pyrosulfite and 10-20 parts of the glycine. Compared with the prior art, the stabilizer is composed of the mycose, the sodium pyrosulfite and the glycine. Therefore, the stability of the piperacillin sodium and the sulbactam sodium in the preparation and storage process is effectively improved. It is guaranteed that products are qualified within the period of validity. The powder-injection is dissolved fast. No crystallization or turbidity exists. The curative effect and safety of clinical usage are guaranteed. A preparation method is simple. The cost is low. The powder-injection is suitable for industrial mass production.