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Suspensoid powder injection of piperacillin sodium sulbactam sodium medicine composition and novel application thereof

A technology of piperacillin sodium sulbactam sodium and penicillin sodium sulbactam sodium, applied in piperacillin sodium sulbactam sodium pharmaceutical composition suspension powder injection and its new application field, can solve the problem of piperacillin sodium sulbactam sodium Problems such as poor stability of bactam sodium, lower compatibility acidity, poor stability, etc., achieve the effect of improving bioavailability, fast dissolution, and low cost

Inactive Publication Date: 2010-12-29
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present inventor is through long-term earnest research, and the suspension powder injection of the piperacillin sodium sulbactam sodium that application emulsification suspension technology and freeze-drying are made solves well the poor stability of piperacillin sodium sulbactam sodium and the Compatible acidity reduces the problem of turbidity; and the combination of piperacillin sodium and sulbactam sodium in a specific ratio overcomes the drug resistance of common oral infection in the prior art, and is very suitable for the treatment of oral infection, thus completing the this invention
It not only solves the problem of its poor stability, but dissolves quickly, and does not produce crystallization and turbidity, and obtains a satisfactory therapeutic effect

Method used

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  • Suspensoid powder injection of piperacillin sodium sulbactam sodium medicine composition and novel application thereof
  • Suspensoid powder injection of piperacillin sodium sulbactam sodium medicine composition and novel application thereof
  • Suspensoid powder injection of piperacillin sodium sulbactam sodium medicine composition and novel application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of Piperacillin Sodium Sulbactam Sodium Suspension Powder Injection

[0049] Prescription (100 bottles):

[0050] Piperacillin Sodium 100g

[0051] Sulbactam Sodium 25g

[0052] Tween 80 150g

[0053] Cholesterol 75g

[0054] Sodium deoxycholate 37.5g

[0055] Trehalose 50g

[0056] Lactose 25g

[0057] Preparation Process

[0058] (1) Add 150g of Tween 80, 75g of cholesterol and 37.5g of sodium deoxycholate into 2000ml of water for injection, then add 100g of piperacillin sodium and 25g of sulbactam sodium and mix evenly, heat and stir in a water bath at 90°C until molten;

[0059] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher for shearing and stirring at a speed of 15000r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 4 times to obtain an emulsion;

[0060] (3) Add 50 g of trehalose and 25 g of lactose to the emulsion, dissolve, filter, subpacka...

Embodiment 2

[0070] Example 2 Preparation of Piperacillin Sodium Sulbactam Sodium Suspension Powder Injection

[0071] Prescription (100 bottles):

[0072] Piperacillin Sodium 200g

[0073] Sulbactam Sodium 50g

[0074] Tween 80 1250g

[0075] Cholesterol 500g

[0076] Sodium deoxycholate 250g

[0077] Sucrose 250g

[0078] Glucose 750g

[0079] Preparation Process

[0080] (1) Add 1250g of Tween 80, 500g of cholesterol and 250g of sodium deoxycholate into 10000ml of water for injection, then add 200g of piperacillin sodium and 50g of sulbactam sodium and mix evenly, heat and stir in a water bath at 70°C until molten;

[0081] (2) Keeping the above liquid at 70-90°C for 20 minutes with a tissue masher to shear and stir at a speed of 10,000 r / min to obtain a primary emulsion, which is then circulated and emulsified by a high-pressure homogenizer for 5 times to obtain an emulsion;

[0082] (3) Add 250 g of sucrose and 750 g of glucose to the emulsion, dissolve, filter, subpackage...

Embodiment 3

[0093] Example 3 Preparation of Piperacillin Sodium Sulbactam Sodium Suspension Powder Injection

[0094] Prescription (100 bottles):

[0095] Piperacillin Sodium 200g

[0096] Sulbactam Sodium 100g

[0097] Tween 80 2500g

[0098] Cholesterol 300g

[0099] Sodium deoxycholate 500g

[0100] Mannitol 250g

[0101] Sodium chloride 50g

[0102] Preparation Process

[0103] (1) Add 2500g of Tween 80, 300g of cholesterol and 500g of sodium deoxycholate into 16000ml of water for injection, then add 200g of piperacillin sodium and 100g of sulbactam sodium and mix evenly, heat and stir in a water bath at 80°C until molten;

[0104] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher to shear and stir at a speed of 12,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0105] (3) Add 250 g of mannitol and 50 g of sodium chloride to the emulsion, dissolve, ...

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Abstract

The invention relates to suspensoid powder injection of a piperacillin sodium sulbactam medicine composition prepared by applying an emulsification suspensoid technology and freeze drying. The invention further relates to a novel application of the suspensoid powder injection in preparing a medicine treating the infection of the oral cavity.

Description

technical field [0001] The invention relates to a suspension powder injection of a piperacillin sodium sulbactam sodium medicinal composition, a preparation method and a new application thereof. Background technique [0002] The oral cavity is one of the ways for pathogenic microorganisms to invade the body. Because the temperature, humidity and food residues in the mouth are suitable for the growth and reproduction of microorganisms. There are a lot of germs in the mouth of normal people. After the operation, the patient's resistance is reduced, and the mouth drinks and eats less, which often makes the bacteria in the mouth multiply and easily causes oral infection. Under normal circumstances, there are more than ten kinds of bacterial flora in the oral cavity, and they restrict and depend on each other to maintain a relatively balanced oral pH of 6.6 to 7.1. Changes in pH in the oral cavity are associated with the incidence of stomatitis. When the pH is lowered, fungal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K31/43A61K9/19A61J3/02A61P1/02
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST
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