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Preparation method of piperacillin sodium sulbactam sodium for injection

A technology of piperacillin sodium sulbactam sodium and cillin sodium sulbactam sodium, which is applied in the field of preparation of piperacillin sodium sulbactam sodium for injection, can solve the problems of allergic reaction, low efficacy and safety of medication, etc. Achieve the effects of reducing allergic reactions, enhancing injection safety, and improving quality

Inactive Publication Date: 2013-09-18
SICHUAN PHARMA
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  • Abstract
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Problems solved by technology

[0004] Most of the existing piperacillin sodium sulbactam sodium for injection is prepared by adding many adjuvant materials to achieve various purposes, but this method itself is to introduce impurities to the drug components themselves, increase the content of related substances, and reduce the content of the main drug components, thereby Cause allergic reactions, resulting in serious consequences such as low efficacy and safety of medication

Method used

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  • Preparation method of piperacillin sodium sulbactam sodium for injection

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Embodiment 1

[0021] The concrete steps of the preparation method of piperacillin sodium sulbactam sodium for injection of the present embodiment are as follows:

[0022] 1. Bottle washing process, pretreatment of injection bottles for sterilization:

[0023] The bottle washing process is as follows: send the injection bottle with qualified quality into the bottle washing track, firstly let the injection bottle enter the ultrasonic cleaning area and make the bottle mouth face down, use ultrasonic wave for initial washing, the frequency of ultrasonic cleaning is 40kHz, and use water after the initial washing is completed. Rinse with purified water with a pressure of 0.25Mpa, then rinse with water for injection filtered through a 0.22μm filter with a water pressure of 0.3Mpa, and finally blow dry with 0.4Mpa of compressed air filtered and purified through a 0.22μm filter. Finally, turn the mouth of the injection bottle upside down and take out the bottle; under the protection of 100-level la...

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Abstract

The invention relates to a preparation method of piperacillin sodium sulbactam sodium for injection. The preparation method comprises the following steps of: moving and mixing the piperacillin sodium and the sulbactam sodium in a sealed container in various directions at a weight ratio of 4:1; discharging the powder after physically mixing the powder; weighing and filling the powder into a barrel; carrying out subsequent treatment to obtain the piperacillin sodium sulbactam sodium for injection. According to the preparation method of the piperacillin sodium sulbactam sodium for injection, only the piperacillin sodium and the sulbactam sodium are selected as raw materials without introducing other novel substances, so that on one hand, the content of main ingredient of the medicament is high, on the other hand, the introduced impurities including related substances and the like are reduced. Moreover, the whole process is strictly controlled, so that the prepared piperacillin sodium sulbactam sodium for injection is low in moisture content, less in visible foreign substances and less in in-soluble particles, and therefore, the anaphylactic reaction during the injection is effectively reduced, and the medicament use is safer.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of piperacillin sodium and sulbactam sodium for injection. Background technique [0002] Piperacillin is a penicillin-like broad-spectrum antibiotic, which mainly plays a bactericidal effect by interfering with the synthesis of bacterial cell walls. It is mainly used for infections caused by Pseudomonas aeruginosa and various Gram-negative bacilli, but it is easily produced by the β- Lactamase is hydrolyzed to produce drug resistance; sulbactam has no antibacterial activity against other bacteria except for Neisseriaceae and Acinetobacter Important β-lactamases are irreversibly inhibited. Sulbactam can prevent drug-resistant bacteria from destroying penicillins and cephalosporins, and sulbactam has obvious synergistic effects with penicillins and cephalosporins. [0003] The effect and safety factors of injection medicine are related to the content of ma...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K9/14A61J3/02A61P31/04A61K31/43
Inventor 刘萍沈山
Owner SICHUAN PHARMA
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